Filters (3 )
Download Results
2,481 research outcomes, page 1 of 249
  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Falo-Sanjuan, Julia; Lammers, Nicholas C; Garcia, Hernan G; Bray, Sarah;
    Publisher: bioRxiv
    Project: RCUK | Programming the Notch Res... (MR/L007177/1), NIH | Genomics (5T32HG000047-18), WT | Cambridge, Developmental ... (109144)

    Summary Information from developmental signaling pathways must be accurately decoded to generate transcriptional outcomes. In the case of Notch, the intracellular domain (NICD) transduces the signal directly to the nucleus. How enhancers decipher NICD in the real time o...

  • publication . Preprint . Article . 2016
    Open Access
    Authors:
    Francis, Jennifer E.; Mason, David; Lévy, Raphaël;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | MICA: Liverpool Imaging P... (MR/K015931/1)

    <jats:p>Semiconductor quantum dots (Qdots) have been utilised as probes in fluorescence microscopy and provide an alternative to fluorescent dyes and fluorescent proteins due to their brightness, photostability, and the possibility to excite different Qdots with a singl...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    E.L. German; C. Solórzano; S. Sunny; F. Dunne; J.F. Gritzfeld; E. Mitsi; E. Nikolaou; A.D. Hyder-Wright; A.M. Collins; S.B. Gordon; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT , RCUK | Experimental Human Pneumo... (MR/M011569/1)

    <jats:title>Abstract</jats:title><jats:p>Widespread use of Pneumococcal Conjugate Vaccines (PCV) has resulted in a reduction in nasopharyngeal colonisation and invasive pneumococcal disease caused by vaccine-types. In a double-blind, randomised controlled trial using th...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Geissmann, Quentin; Garcia Rodriguez, Luis; Beckwith, Esteban J.; Gilestro, Giorgio F.;
    Project: RCUK | BB/J014575/1 (BB/J014575/1), EC | SEX_FIGHT_SLEEP (705930)

    <jats:title>Abstract</jats:title><jats:p>The recent development of automatised methods to score various behaviours on a large number of animals provides biologists with an unprecedented set of tools to decipher these complex phenotypes. Analysing such data comes with se...

  • publication . Article . Preprint . Other literature type . 2016
    Open Access
    Authors:
    Gustavo Deco; Joana Cabral; Mark W. Woolrich; Angus B.A Stevner; Tim J. van Hartevelt; Morten L. Kringelbach;
    Project: EC | CAREGIVING (615539), WT , EC | DYSTRUCTURE (295129), EC | HBP SGA1 (720270), RCUK | Building multi-site clini... (MR/K005464/1)

    Graphical abstract fx1

  • publication . Preprint . 2020
    Open Access
    Authors:
    Pinotsis, Dimitris A.; Miller, Earl K.;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | The self as agent-environ... (ES/T01279X/1), NIH | Cortical Circuits for Att... (5R37MH087027-02)

    <jats:title>Abstract</jats:title><jats:p>Neural activity is organized at multiple scales, ranging from the cellular to the whole brain level. Connecting neural dynamics at different scales is important for understanding brain pathology. Neurological diseases and disorde...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Hiu-Gwen Tsang; Emily L. Clark; Greg R. Markby; Stephen J. Bush; David A. Hume; Brendan M. Corcoran; Vicky E. MacRae; Kim M. Summers;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Functional Annotation of ... (BB/L001209/1), RCUK | EASTBIO DTP (BB/J01446X/1), RCUK | Future-Proofing the Susta... (MR/K001744/1)

    <jats:title>Abstract</jats:title><jats:p>Large animal models are of increasing importance in cardiovascular disease research as they demonstrate more similar cardiovascular features (in terms of anatomy, physiology and size) to humans than do rodent species. The mainten...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Leonid A Mirny; Geoffrey Fudenberg;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Structural Annotation of ... (5R01HG003143-13), RCUK | How does Condensin mediat... (BB/J018554/1)

    <jats:p>Structural Maintenance of Chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply-conserved SMC complexes, organize chromosomes in budding yeast. The ca...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Slawomir Michniewski; Tamsin Redgwell; Aurelija Grigonyte; Branko Rihtman; Maria Aguilo-Ferretjans; Joseph Christie-Oleza; Eleanor Jameson; David J. Scanlan; Andrew D. Millard;
    Publisher: Wiley
    Project: RCUK | The MRC Consortium for Me... (MR/L015080/1), RCUK | EVAL-FARMS: Evaluating th... (NE/N019881/1)

    <jats:title>Summary</jats:title><jats:p>Bacteriophages infecting <jats:italic>Escherichia coli</jats:italic> have been used as a proxy for faecal matter and water quality from a variety of environments. However, the diversity of coliphages that are present in seawater r...

  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Suderman, Matthew; Staley, James R; French, Robert; Arathimos, Ryan; Simpkin, Andrew; Tilling, Kate;
    Publisher: bioRxiv
    Project: RCUK | Data mining and bioinform... (MC_UU_12013/8), RCUK | Epigenetic Epidemiology (MC_UU_12013/2)

    <jats:p>A differentially methylated region (DMR) is a genomic region in which DNA methylation is consistently positively or negatively associated with a phenotype or exposure. We demonstrate that existing algorithms for identifying DMRs either fail to consistently contr...

2,481 research outcomes, page 1 of 249
Last index information