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3,642 research outcomes, page 1 of 365
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Papadimitriou, I.; Utton, C.; Tsakiropoulos, P.;
    Publisher: MDPI AG
    Project: RCUK | Structural Metallic Syste... (EP/H500405/1)

    C) were analysed using XRD (X-ray diffraction) and SEM/EDS (scanning electron microscopy/ electron dispersive x-ray spectroscopy). Tin showed a high solubility in Nb2Al, reaching up to 21 at.% in the Sn-rich areas, substituting for Al atoms. Tin and Al also substituted ...

  • publication . Article . 2017
    Open Access
    Authors:
    Wood, HM; Foster, JM; Taylor, M; Tinkler-Hundal, E; Togneri, FS; Wojtowicz, P; Oumie, A; Spink, KG; Brew, F; Quirke, P;
    Publisher: Springer Nature
    Project: RCUK | Developing a robust relia... (101032)

    Background The importance of accurate and affordable mutation calling in fixed pathology samples is becoming increasingly important as we move into the era of personalised medicine. The Affymetrix OncoScan® Array platform is designed to produce actionable mutation calls...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Dehghani-Tafti, Saba; Sanders, Cyril M.;
    Publisher: Oxford University Press
    Project: RCUK | Opening of a double stran... (BB/K019252/1), RCUK | A quantitative biomolecul... (BB/L013851/1)

    Abstract UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm. Human UPF1 (hUPF1) is also needed for nuclear DNA replication. While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response and ce...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Aguilar Cosme, J.R.; Bryant, H.E.; Claeyssens, F.;
    Publisher: Public Library of Science
    Project: RCUK | CVD DIAMOND AS A SUBSTRAT... (EP/K002503/1)

    Photodynamic therapy (PDT) uses photosensitisers such as protoporphyrin IX (PpIX) to target tumours via the release of toxic singlet oxygen when irradiated. The effectivity of the treatment is limited by the innate properties of the photosensitizers; they typically exhi...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    E. Hernández-Nava; P. Mahoney; C. J. Smith; J. Donoghue; I. Todd; S. Tammas-Williams;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Designing alloys for reso... (EP/L025213/1), RCUK | MAPP: EPSRC Future Manufa... (EP/P006566/1)

    Abstract A methodology has been demonstrated to consolidate Ti-6Al-4V powder without taking it to the liquid state by novel combination of the electron beam melting additive manufacture and hot isostatic pressing processes. This results in improved static mechanical pro...

  • publication . Article . 2016
    Open Access English
    Authors:
    Jon Sayers; IO NAM WONG;
    Publisher: Nature Publishing Group
    Project: RCUK | The Metallobiochemistry o... (BB/F014732/1)

    Helicases catalyze the unwinding of double-stranded nucleic acids where structure and phosphate backbone contacts, rather than nucleobase sequence, usually determines substrate specificity. We have expressed and purified a putative helicase encoded by the D10 gene of ba...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Gregory Hurst; Chris Corbin; Julia Ferrari;
    Project: RCUK | Temperature impacts on pa... (NE/G003246/1)

    Heritable microbes represent an important component of the biology, ecology and evolution of many plants, animals and fungi, acting as both parasites and partners. In this review, we examine how heritable symbiont–host interactions may alter host thermal tolerance, and ...

  • publication . Article . 2015
    Open Access English
    Authors:
    P. J. Boyd; V. T. Cunliffe; S. Roy; J. D. Wood;
    Publisher: Company of Biologist
    Project: RCUK | Centre for Biomedical Gen... (G0400100), RCUK | Centre for Developmental ... (G0700091)

    ABSTRACT DISRUPTED-IN-SCHIZOPHRENIA (DISC1) has been one of the most intensively studied genetic risk factors for mental illness since it was discovered through positional mapping of a translocation breakpoint in a large Scottish family where a balanced chromosomal tran...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Emma Curran; Stephanie L Burg; Melanie Brien; Nicola J. Nadeau; Andrew Parnell; Simon Martin;
    Publisher: The Royal Society
    Project: RCUK | Testing repeatability in ... (NE/K008498/1), RCUK | A Coordinated, Comprehens... (EP/K001329/1)

    <jats:p> Iridescence is an optical phenomenon whereby colour changes with the illumination and viewing angle. It can be produced by thin film interference or diffraction. Iridescent optical structures are fairly common in nature, but relatively little is known about the...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Mingling Sun; Takahide Kubota; Edward Jackson; Atsufumi Hirohata;
    Publisher: Nature Publishing Group UK
    Project: RCUK | Spintronic Devices for In... (EP/M02458X/1), EC | HARFIR (604398)

    Abstract Current information technology relies on the advancement of nanofabrication techniques. For instance, the latest computer memories and hard disk drive read heads are designed with a 12 nm node and 20 nm wide architectures, respectively. With matured nanofabrica...

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