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246 research outcomes, page 1 of 25
  • publication . Article . Other literature type . 2010
    Open Access English
    Authors:
    Ross McManus; Sarah Hunt; Elvira Grandone; Panos Deloukas; Graham A Heap; Jeffrey Barrett; Katherine Irene Morley; Alexandra Zhernakova; Bozena Cukrowska; Gosia Trynka; ...
    Project: RCUK | Functional investigation ... (G0700545), WT | WTCCC2 core activities (085475), NWO | Identifying causative cop... (2300159001), EC | COPACETIC (201379), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), WT | Extended genome wide asso... (084743)

    We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 control...

  • publication . Article . Conference object . 2015
    Open Access
    Authors:
    Rampal S. Etienne; david alonso;
    Project: NSF | LTREB: Long-Term Studies ... (0640386), NSF | What Causes Large Local-S... (9615226), NSF | The Neutral Theory of Bio... (0346488), NSF | The Dynamics of a Neotrop... (0425651), NSF | The Dynamics of a Neotrop... (9405933), NSF | Theoretical and Empirical... (0129874), RCUK | Perturbed Neutrality - be... (NE/H007458/1)

    Peer reviewed

  • publication . Other literature type . Article . 2018 . Embargo End Date: 01 Sep 2018
    Open Access
    Authors:
    Björn Hellenkamp; Sonja Schmid; Olga Doroshenko; Oleg Opanasyuk; Ralf Kühnemuth; Soheila Rezaei Adariani; Benjamin Ambrose; Mikayel Aznauryan; Anders Barth; Victoria Birkedal; ...
    Publisher: Nature Publishing Group
    Project: NSF | CAREER: Structural dynami... (1749778), EC | SMPFv2.0 (646451), EC | SM-IMPORT (638536), NIH | Quantitative Imaging and ... (1R01GM112659-01), RCUK | Single-molecule analysis ... (BB/H01795X/1), EC | POLMACHINE (261227), EC | hybridFRET (671208), NIH | Trinucleotide Repeats: At... (5R01GM118508-02), NIH | Quantitative analysis of ... (5R01GM109832-02), EC | PROSINT (681891)

    Single-molecule Forster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However, generalized protocols and FRET standards to ensure the reproducibility and accuracy of m...

  • publication . Article . Preprint . 2016
    Open Access English
    Authors:
    Simon Dye; Cedric Lacey; Peder Norberg; William Cowley;
    Project: EC | ASTRODEEP (312725), EC | DEGAS (259586), EC | CosmicDust (647939), RCUK | Durham Astronomy Consolid... (ST/L00075X/1)

    Comment: 5 pages including appendix, 4 figures, accepted for publication as a letter in A&A

  • publication . Article . Conference object . 2016
    Open Access
    Authors:
    Aartjan te Velthuis; Robert Tampé; Ervin Fodor;
    Project: RCUK | Extending the Boundaries ... (BB/J001694/1), WT | Molecular mechanisms and ... (110164), WT | Decoding the influenza A ... (098721), EC | SM-IMPORT (638536), NWO | Resolving the dynamics of... (2300171136), RCUK | Single-molecule analysis ... (MR/N010744/1), RCUK | Replication of influenza ... (MR/K000241/1)

    Influenza viruses have a segmented viral RNA (vRNA) genome, which is replicated by the viral RNA-dependent RNA polymerase (RNAP). Replication initiates on the vRNA 3΄ terminus, producing a complementary RNA (cRNA) intermediate, which serves as a template for the synthes...

  • publication . Article . Conference object . 2018
    Open Access
    Authors:
    Lewis Spurgin; Hannah L Dugdale;
    Publisher: Wiley
    Project: RCUK | Telomeres as biomarkers o... (NE/F02083X/1), RCUK | Quantitative genetics of ... (NE/I021748/1), RCUK | The genomics of thermal a... (BB/N011759/1), RCUK | Transgenerational impacts... (NE/K005502/1)

    Understanding individual-level variation in response to the environment is fundamental to understanding life-history evolution and population dynamics. Telomeres, the protective caps at the ends of chromosomes, shorten in response to oxidative stress, and telomere short...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Karl Glazebrook; Shahab Joudaki; Henk Hoekstra; Nicola Rosario Napolitano; Hendrik Hildebrandt; Christian Wolf; David Parkinson; Konrad Kuijken; Arun Kannawadi;
    Project: NWO | KiDS: Studying the Dark U... (2300171781), NSF | Final Design, Constructio... (1258333), EC | ADULT (279396), EC | GLOBE (647112), RCUK | A multi-probe strategy to... (ST/L00285X/1)

    Comment: 24 pages, 20 figures. Submitted to MNRAS. Comments welcome

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shrine, Nick; Guyatt, Anna L; Erzurumluoglu, A Mesut; Jackson, Victoria E; Hobbs, Brian D; Melbourne, Carl A; Batini, Chiara; Fawcett, Katherine A; Song, Kijoung; Sakornsakolpat, Phuwanat; ...
    Project: EC | LIFECYCLE (733206), RCUK | Discovery of genome-wide ... (MR/N011317/1), EC | EURHEALTHAGEING (277849), WT | Large-scale genomic epide... (202849), EC | DYNAHEALTH (633595)

    Editorial summary: A genome-wide association study in over 400,000 individuals identifies 139 new signals for lung function. These variants can predict chronic obstructive pulmonary disease in independent, trans-ethnic cohorts.

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Roselinde van der Wiel; Clara Mulder;
    Project: RCUK | Partner Relationships, Re... (ES/L01663X/1), EC | FamilyTies (740113)

    Abstract The non-institutionalised, flexible nature of living-apart-together (LAT) raises questions about partner commitment in the context of the debate about the individualisation of society. We explored how partner commitment in LAT relationships in the Netherlands i...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Luigi Fontana;
    Publisher: Wiley
    Project: NIH | Washington University Ins... (3UL1RR024992-03S4), RCUK | Do hunger neuropeptides m... (BB/G009953/1)

    Summary Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti‐aging effects of CR, but mechanisms of regulation are poorly understood. Cellul...

246 research outcomes, page 1 of 25
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