Filters (3 )
Download Results
146 research outcomes, page 1 of 15
  • publication . Article . 2015
    Open Access
    Authors:
    Conor McCann;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Using key models for deve... (G0800973)

    textabstractObjectives Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue. The study aims to better u...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Hammond CJ; René Höhn; CCW Klaver; Paul Foster; Ruth E. Hogg; Fotis Topouzis; V.J.M. Verhoeven; Anthony P Khawaja; Katie M Williams; Robert Luben; ...
    Project: NWO | NCHA Subsidiebesluit 2008... (2300155116), WT | Genetics of ageing: the g... (081878), RCUK | Diet, lifestyle and biolo... (G1000143), RCUK | Assessment of biomedical ... (G0000934)

    Published version also available at <a href=http://dx.doi.org/10.1016/j.ophtha.2015.03.018>http://dx.doi.org/10.1016/j.ophtha.2015.03.018</a> Purpose: To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Xiong, Ziyi; Dankova, Gabriela; Howe, Laurence J; Lee, Myoung Keun; Hysi, Pirro G; de Jong, Markus A; Zhu, Gu; Adhikari, Kaustubh; Li, Dan; Li, Yi; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: WT , NIH | 3D Analysis of Normal Fac... (5U01DE020078-04), NWO | NCHA Subsidiebesluit 2008... (2300155116), NHMRC | Advancing our understandi... (1103623), NIH | The Genetic Architecture ... (5R01DE027023-02), EC | VISAGE (740580), NIH | Health outcomes and impro... (1R01DD000295-01), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | The genetics of human phy... (BB/I021213/1), NIH | Extending the Phenotype o... (5R01DE016148-12)

    <jats:title>Abstract</jats:title><jats:p>The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited despite the relevance for various fields of science and application. A series of genome-wide assoc...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Geoffrey Bird; Renske van der Cruijsen;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Kings College London ESRC... (ES/J500057/1)

    textabstractSymptoms of internalizing disorders such as depression and anxiety increase in adolescence, especially in females. However, gender differences in depression and anxiety symptoms emerge only after puberty onset. Levels of alexithymia, characterized by difficu...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Pieter L. van den Berg;
    Publisher: Informa UK Limited
    Project: RCUK | The LANCS (Lancaster, Not... (EP/F033338/1), NWO | From Reactive to Proactiv... (2300168597)

    Emergency Medical Service (EMS) systems worldwide are complex systems, characterised by significant variation in service providers, care pathways, patient case-mix and quality care indicators. Analysing and improving them is therefore challenging. Since EMS systems diff...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Sean Saunders; Alan D. Irvine; Padraic G. Fallon; WH McLean;
    Project: WT | Human and mouse genetics ... (092530), WT | The establishment of a la... (090066), RCUK | In vivo model systems to ... (G0700314)

    Background: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory IL-1 cytoki...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Ahmad Vaez; Henning Tiemeier; Caroline Relton; Eva Corpeleijn; Rebecca Richmond; Soesma Jankipersadsing; Sacha la Bastide-van Gemert; Janine Felix; Leanne Küpers;
    Project: NIH | Novel Epigenomic Biomarke... (5R01NR013945-02), WT , NWO | NCHA Subsidiebesluit 2008... (2300155116), NWO | Individual development: W... (2300176472), RCUK | Accessible resource for i... (BB/I025263/1), NIH | Early Life DNA Methylatio... (1R01HL111108-01A1)

    Background: We examined whether the effect of maternal smoking during pregnancy on birthweight of the offspring was mediated by smoking-induced changes to DNA methylation in cord blood. Methods: First, we used cord blood of 129 Dutch children exposed to maternal smoking...

  • publication . Article . Other literature type . Preprint . 2018
    Open Access English
    Authors:
    Roberta Ghidoni; Daniela Galimberti; Kejal Kantarci; Giacomina Rossi; Sebastian Crutch; Giuliano Binetti; Anton Porsteinsson; Laura L. Boles Ponto; Giorgio Giulio Fumagalli; James Rowe; ...
    Project: EC | EuroPOND (666992), RCUK | Seeing what they see: com... (ES/L001810/1), RCUK | UK Dementias Platform (MR/L023784/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), WT | Restoring brain function:... (103838), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), RCUK | Developing an evidence ba... (MR/M008525/1), RCUK | Computational PLatform fo... (EP/M006093/1), CIHR ,...

    Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and d...

  • publication . Article . 2019
    Open Access English
    Authors:
    Gunnar Naulaers; Joseph Cherian Perumpillichira;
    Publisher: Elsevier
    Project: WT | Sleep and Circadian Neuro... (098461), EC | BIOTENSORS (339804), RCUK | Centre for Doctoral Train... (EP/G036861/1)

    BACKGROUND: To improve the objective assessment of continuous video-EEG (cEEG) monitoring of neonatal brain function, the aim was to relate automated derived amplitude and duration parameters of the suppressed periods in the EEG background (dynamic Interburst Interval= ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Thomas Meitinger; René Höhn; CCW Klaver; Omar Mahroo; Paul Foster; Hammond CJ; Ruth E. Hogg; Fotis Topouzis; V.J.M. Verhoeven; Anthony P Khawaja; ...
    Publisher: HAL CCSD
    Project: NWO | NCHA Subsidiebesluit 2008... (2300155116), RCUK | Diet, lifestyle and biolo... (G1000143), WT | Genetics of ageing: the g... (081878), RCUK | Assessment of biomedical ... (G0000934)

    To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E3) Consortium were com...

146 research outcomes, page 1 of 15
Last index information