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3,829 research outcomes, page 1 of 383
  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Dan Charman; Cristian Estop-Aragonés; Stephen Wolfe; Nicole Sanderson; Mathew Williams;
    Publisher: Elsevier BV
    Project: RCUK | Carbon Cycling Linkages o... (NE/K000241/1), RCUK | CYCLOPS: Carbon Cycling L... (NE/K000179/1)

    Permafrost stores globally significant amounts of carbon (C) which may start to decompose and be released to\ud the atmosphere in form of carbon dioxide (CO2) and methane (CH4) as global warming promotes extensive thaw.\ud This permafrost carbon feedback to climate is c...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Daniela Annibali; Thilo Dörk; Camilla Krakstad; Stuart MacGregor; Emma Tham; Alexander Hein; Anthony Swerdlow; Dale R Nyholt; Jodie Painter; Tracy O'Mara; ...
    Project: CIHR , NHMRC | Characterising the trajec... (443036), NHMRC | Develop & improve methodo... (339462), NHMRC | Validation and Replicatio... (496739), NHMRC | A genome-wide association... (552402), WT , NHMRC | Molecular Epidemiology of... (339435), WT | Genome wide association s... (084766), NHMRC | Genetics of melanoma risk... (241944), WT | The genetics of weight, B... (076113),...

    Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used ge...

  • publication . Article . 2016
    Open Access
    Authors:
    Christopher D Lucas; Scott Webster; Karen Chapman;
    Publisher: The Endocrine Society
    Project: RCUK | How does 11B-hydroxystero... (G0800235), WT | 11 beta-hydroxysteroid de... (078269), RCUK | Induction of neutrophil a... (G0601481), WT | Clinical PhD Programme at... (094415), RCUK | The Role of Cyclin-Depend... (MR/K013386/1), WT | 11beta hydroxysteroid deh... (083184)

    <jats:p>Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respecti...

  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Boris Reizis; Neil Mabbott;
    Project: RCUK | Determining the role of C... (BB/F019726/1)

    <jats:title>ABSTRACT</jats:title> <jats:p>After oral exposure, the early replication of certain prion strains upon stromal cell-derived follicular dendritic cells (FDC) in the Peyer's patches in the small intestine is essential for the efficient spread of disease to the...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Tsuji, Takahiro; Tsuji, Chiharu; Lozic, Maja; Ludwig, Mike; Leng, Gareth;
    Publisher: Wiley
    Project: RCUK | Vasopressin and the anter... (BB/J004723/1), RCUK | Vasopressin and the retin... (MR/M022838/1)

    The output cells of the main olfactory bulb project via the lateral olfactory tract (LOT) to the anterior olfactory nucleus (AON), but how AON neurons process that information is not well understood. We recorded the electrical activity of AON neurons in anaesthetized ra...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Annie Ginty; Janet Lord; Rachel Cooper; John Mathers; Ian J Deary;
    Publisher: Springer Nature
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1), RCUK | Development of interventi... (G0900686)

    Abstract Background There is no criterion reference for assessing healthy ageing and this creates difficulties when conducting and comparing research on ageing across studies. A cardinal feature of ageing is loss of function which translates into wide-ranging consequenc...

  • publication . Article . 2015
    Open Access English
    Authors:
    Bolton, Ronan; Foxon, Timothy J.;
    Publisher: The Authors. Published by Elsevier B.V.
    Project: RCUK | Realising Transition Path... (EP/K005316/1)

    Abstract The UK is moving into a new phase of energy governance which is characterised by significant demand for new investment to meet long term climate policy objectives and to address shorter term energy security challenges. This paper examines how contributions from...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Schmieschek, S.; Shamardin, L.; Frijters, S.; Krüger, T.; Schiller, U.D.; Harting, J.; Coveney, P.V.;
    Publisher: ELSEVIER SCIENCE BV
    Project: EC | CONTRA CANCRUM (223979), EC | ComPat (671564), RCUK | UK Consortium on Mesoscal... (EP/L00030X/1)

    We introduce the lattice-Boltzmann code LB3D, version 7.1. Building on a parallel program and supporting tools which have enabled research utilising high performance computing resources for nearly two decades, LB3D version 7 provides a subset of the research code functi...

  • publication . Article . 2015
    Open Access English
    Authors:
    Kai A. Kropp; Thorsten Forster; Wolfram Brune; Ana Angulo; Peter Ghazal;
    Publisher: Public Library of Science
    Project: WT | Molecular determinants of... (066784), RCUK | Centre for Systems Biolog... (BB/D019621/1)

    Author Summary Here we discover how inflammatory signalling may unintentionally promote infection, as a result of viruses evolving DNA sequences, known as enhancers, which act as a bait to prey on the infected cell transcription factors induced by inflammation. The majo...

  • publication . Other literature type . Article . Preprint . 2017
    Open Access
    Authors:
    Choudhury, Nila Roy; Heikel, Gregory; Trubitsyna, Maryia; Kubik, Peter; Nowak, Jakub Stanislaw; Webb, Shaun; Granneman, Sander; Spanos, Christos; Rappsilber, Juri; Castello, Alfredo; ...
    Publisher: Springer Science and Business Media LLC
    Project: WT | Core funding renewal for ... (092076), WT , WT | Three-dimensional proteom... (084229), WT | Core support for Wellcome... (077707), RCUK | Future-Proofing the Susta... (MR/K001744/1), WT | Proteomics at the Wellcom... (091020), WT | Wellcome Trust four year ... (096996), WT | Wellcome Trust PhD Progra... (105246)

    Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Further...

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