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259 research outcomes, page 1 of 26
  • publication . Article . 2017
    Open Access English
    Authors:
    David O Bates; James Bainbridge;
    Publisher: Portland Press Limited on behalf of the Biochemical Society
    Project: RCUK | Functional significance o... (MR/K020366/1)

    <jats:p>Diabetic retinopathy (DR) is one of the leading causes of blindness in the developed world. Characteristic features of DR are retinal neurodegeneration, pathological angiogenesis and breakdown of both the inner and outer retinal barriers of the retinal vasculatu...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Sims, Rebecca; Van Der Lee, Sven J; Naj, Adam C; Bellenguez, Céline; Badarinarayan, Nandini; Jakobsdottir, Johanna; Kunkle, Brian W; Boland, Anne; Raybould, Rachel; Bis, Joshua C; ...
    Publisher: Nature Publishing Group
    Project: NIH | Collaborative GWAS of Dem... (1R01AG033193-01), NIH | Progression of Dementia: ... (5R01AG021136-02), NIH | Multi-ethnic genome-wide ... (5R01AG025259-04), NIH | ALZHEIMERS DISEASE RESEAR... (5P50AG005136-21), NIH | CHARGE: Identifying Risk ... (5U01AG049505-02), NIH | EPIDEMIOLOGY OF ALZHEIMER... (5R01AG011380-02), NIH | Imaging Neuroinflammation... (1RC2AG036502-01), NIH | Genetic Architecture of A... (5R01NS085419-04), NIH | Oregon Alzheimer's Diseas... (3P30AG008017-28S2), WT | Autophagy in health and d... (095317),...

    International audience; We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < ...

  • publication . Article . 2014
    Open Access
    Authors:
    Stubbington, R; Boulton, AJ; Little, S; Wood, PJ;
    Publisher: University of Chicago Press
    Project: RCUK | The response of aquatic i... (NE/E001769/1)

    Droughts are unpredictable disturbances characterized in streams by declining flow, reduced habitat availability, and deteriorating abiotic conditions. Such events typically reduce benthic invertebrate taxon richness and modify assemblage composition, but little is know...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Gareth McVicker; Stephen Renshaw; Tomasz Prajsnar;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Zebrafish genetic approac... (G0701932), EC | FISHFORPHARMA (289209), WT | Staphylococcus aureus hos... (089981), EC | PAR (241476), RCUK | Centre for Developmental ... (G0700091)

    Author Summary Staphylococcus aureus is a major cause of human disease, made even more notable due to the spread of antibiotic resistance. We used a combination of animal models to study the spread of bacteria between organs during an infection and the resulting effect ...

  • publication . Article . 2012
    Open Access
    Authors:
    Helen Brown; M. Gareth Gaskell; Anna Weighall;
    Publisher: Elsevier BV
    Project: RCUK | Neural and behavioural co... (ES/E015263/1)

    Recent studies of adults have found evidence for consolidation effects in the acquisition of novel words, but little is known about whether such effects are found developmentally. In two experiments, we familiarized children with novel nonwords (e.g., biscal) and tested...

  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Richard A. Fallows; Biagio Forte; Ivan Astin; Tom Allbrook; Alex Arnold; Alan Wood; Gareth Dorrian; Maaijke Mevius; Hanna Rothkaehl; Barbara Matyjasiak; ...
    Publisher: HAL CCSD
    Project: RCUK | Space weather disruptions... (NE/R009082/1), EC | LOFAR4SW (777442)

    This paper presents the results from one of the first observations of ionospheric scintillation taken using the Low-Frequency Array (LOFAR). The observation was of the strong natural radio source Cas A, taken overnight on 18-19 August 2013, and exhibited moderately stro...

  • publication . Article . 2015
    Open Access
    Authors:
    Robert Morris; David Fairhurst; Glen McHale; Nicasio Geraldi;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Engineering of surfaces f... (EP/G057265/1)

    In recent years extensive work has been focused onto using superhydrophobic surfaces for drag reduction applications. Superhydrophobic surfaces retain a gas layer, called a plastron, when submerged underwater in the Cassie-Baxter state with water in contact with the top...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Gregory de Boer; Vassili Toropov; Rob Hewson;
    Publisher: Elsevier BV
    Project: RCUK | Beyond The Lubrication Ap... (EP/I013733/1)

    Derived from the Heterogeneous Multiscale Methods (HMM), a two-scale method is developed for the analysis of Elastohydrodynamic Lubrication (EHL) and micro-EHL in tilted-pad bearings with three-dimensional topography. A relationship linking the pressure gradient to mass...

  • publication . Article . Other literature type . 2010
    Open Access English
    Authors:
    Christopher Hardacre; Glen McHale; Dmitriy Kuvshinov;
    Publisher: American Institute of Physics
    Project: RCUK | An Integrated, Single Pas... (EP/D03826X/1), RCUK | An Integrated, Single Pas... (EP/D038294/1)

    A microfluidic glass chip system incorporating a quartz crystal microbalance (QCM) to measure the square root of the viscosity-density product of room temperature ionic liquids (RTILs) is presented. The QCM covers a central recess on a glass chip, with a seal formed by ...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Coates, Graham; Alharbi, Meshal; Li, Chunhui; Ahilan, Sangaralingam; Wright, Nigel;
    Publisher: Royal Society
    Project: RCUK | Organisational Operationa... (EP/K012770/1)

    <jats:p>The resilience of small and medium-sized enterprises (SMEs) to disruptive events is significant as this highly prevalent category of business forms the economic backbone in developed countries. This article provides an overview of the application of a computatio...

259 research outcomes, page 1 of 26
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