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206 research outcomes, page 1 of 21
  • publication . Conference object . Article . 2017
    Open Access
    Authors:
    Peter Gardner; Peter Garred; Steven Sacks; Anai Gonzalez-Cordero;
    Project: RCUK | A flow cytometry facility... (MR/L012758/1)

    Age-related macular degeneration (AMD) is a major cause of blindness and is associated with complement dysregulation. The disease is a potential target for stem cell therapy but success is<br/>likely to be limited by the inflammatory response. We investigated the innate...

  • publication . Article . Conference object . 2017
    Open Access
    Authors:
    Yunyan Zhang; H. Aruni Fonseka; Martin Aagesen; James A. Gott; Ana M. Sanchez; Jiang Wu; Dongyoung Kim; Pamela Jurczak; Suguo Huo; Huiyun Liu;
    Publisher: American Chemical Society (ACS)
    Project: RCUK | GaAsP-GaAs nanowire quant... (EP/P000916/1)

    The growth of self-catalyzed core–shell nanowires (NWs) is investigated systematically using GaAs(P) NWs. The defects in the core NW are found to be detrimental for the shell growth. These defects are effectively eliminated by introducing beryllium (Be) doping during th...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Lisa Ann Owens; Stine Gry Kristensen; Avi Lerner; Georgios Christopoulos; Stuart Lavery; Aylin C Hanyaloglu; Kate Hardy; Claus Yding Andersen; Stephen Franks;
    Publisher: Endocrine Society
    Project: RCUK | Role of growth factors of... (MR/M012638/1)

    Abstract Context Polycystic ovary syndrome (PCOS) is the most common cause of anovulation. A key feature of PCOS is arrest of follicles at the small- to medium-sized antral stage. Objective and Design To provide further insight into the mechanism of follicle arrest in P...

  • publication . Article . 2017
    Open Access English
    Authors:
    Anders Johannes Hansen; José Alfredo Samaniego Castruita; Bent Petersen; Lukas F.K. Kuderna; Thomas Sicheritz-Ponten; Shyam Gopalakrishnan; Love Dalén; M Thomas P Gilbert; Mikkel-Holger S. Sinding;
    Project: RCUK | Deciphering dog domestica... (NE/K005243/1), RCUK | Deciphering dog domestica... (NE/K003259/1), EC | Extinction Genomics (681396), EC | WhereWolf (655732), EC | UNDEAD (337574)

    Background: An increasing number of studies are addressing the evolutionary genomics of dog domestication, principally through resequencing dog, wolf and related canid genomes. There is, however, only one de novo assembled canid genome currently available against which ...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access English
    Authors:
    Hector Chinoy; Jamie Sergeant; Louise Diederichsen; Søren Jacobsen; James Lilleker;
    Publisher: Oxford University Press
    Project: RCUK | MICA: A UK-wide networkin... (MR/N003322/1)

    Objectives<br/>Limitations in the methods available for identifying cardiac involvement and accurately quantifying disease activity in the idiopathic inflammatory myopathies (IIM) may contribute to poor outcomes. <br/>We investigated the utility of different serum muscl...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ekoru, K; Murphy, GAV; Young, EH; Delisle, H; Jerome, CS; Assah, F; Longo-Mbenza, B; Nzambi, JPD; On'Kin, JBK; Buntix, F; ...
    Project: RCUK | Research partnership to a... (MR/K013491/1), WT

    BACKGROUND: Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation in the association between adiposity and cardiometabolic disease and availability of data fro...

  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    Christian Bick; Marc Goodfellow; Carlo R. Laing; Erik A. Martens;
    Project: EC | GECO (626111), WT | Institutional Strategic S... (105618), RCUK | Quantifying uncertainty i... (EP/P021417/1), WT , RCUK | EPSRC Centre for Predicti... (EP/N014391/1)

    Abstract Many biological and neural systems can be seen as networks of interacting periodic processes. Importantly, their functionality, i.e., whether these networks can perform their function or not, depends on the emerging collective dynamics of the network. Synchrony...

  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Jonathan Butterworth; Benjamin Allanach;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Particles, Fields and Ext... (ST/P000681/1), EC | MCnetITN3 (722104)

    We examine current collider constraints on some simple $Z^\prime$ models that fit neutral current $B-$anomalies, including constraints coming from measurements of Standard Model (SM) signatures at the LHC. The `MDM' simplified model is not constrained by the SM measurem...

  • publication . Article . 2016
    Open Access English
    Authors:
    David Burt; Marta Farré; Joana Damas;
    Project: RCUK | Genome assembly. chromoso... (BB/K008161/1), RCUK | Using reference-assisted ... (BB/J010170/1), RCUK | Genome assembly. chromoso... (BB/K008226/1)

    Homologous synteny blocks (HSBs) and evolutionary breakpoint regions (EBRs) in mammalian chromosomes are enriched for distinct DNA features, contributing to distinct phenotypes. To reveal HSB and EBR roles in avian evolution, we performed a sequence-based comparison of ...

  • publication . Other literature type . Article . Conference object . 2019
    Open Access
    Authors:
    Inge Marie Svane; Marine Estelle Caillaud; David Cole; Marco Donia; Andrew Sewell;
    Publisher: Frontiers Media SA
    Project: RCUK | Comprehensive analysis of... (BB/H001085/1), WT | The molecular rules that ... (095767), WT | Characterization and opti... (086716)

    Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL). While these approaches have shown great promise, they are only effective in some patients ...

206 research outcomes, page 1 of 21
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