Filters (3 )
Download Results
220 research outcomes, page 1 of 22
  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Dekkers, Ilona A.; de Boer, Anneloes; Sharma, Kaniska; Cox, Eleanor F.; Lamb, Hildo J.; Buckley, David L.; Bane, Octavia; Morris, David M.; Prasad, Pottumarthi V.; Semple, Scott I. K.; ...
    Project: FWF | MR-Progression-Evaluation... (KLI 736), NIH | Quantification of Renal P... (1F32DK109591-01A1), NIH | Longitudinal changes in t... (5R01DK093793-02), RCUK | UK Renal Imaging Network ... (MR/R02264X/1), NIH | Intrarenal Oxygenation: A... (5R01DK106557-03)

    To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus pro...

  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Joep de Ligt; Christian Gilissen; J.H.L.M. (Hans) van Bokhoven; Carine Carels; Charlotte Ockeloen; Jasmien Roosenboom;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Prevention of cleft palat... (G0901539), NIH | Nonrecurrent rearrangemen... (5R01NS058529-05), NIH | Baylor-Johns Hopkins Cent... (5U54HG006542-03), RCUK | Deciphering the role of p... (MR/M012174/1)

    PURPOSE: We aimed to identify a novel genetic cause of tooth agenesis (TA) and/or orofacial clefting (OFC) by combining whole-exome sequencing (WES) and targeted resequencing in a large cohort of TA and OFC patients. METHODS: WES was performed in two unrelated patients:...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Yvonne van der Schouw; Michael Sweeting; ELENA MOLINA PORTILLO; Adam Butterworth; Therese Haugdahl Nøst; Elio Riboli; Camille Lassale; Kim Overvad; Ioanna Tzoulaki; alessandro bisconti; ...
    Publisher: HAL CCSD
    Project: RCUK | Large-scale integrative s... (MR/L003120/1), WT , EC | EPICHEART (268834), RCUK | Study of the interplay of... (G0800270), EC | EPIC-CVD (279233), RCUK | Health of vegetarians (MR/M012190/1)

    OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence ...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Xiong, Ziyi; Dankova, Gabriela; Howe, Laurence J; Lee, Myoung Keun; Hysi, Pirro G; de Jong, Markus A; Zhu, Gu; Adhikari, Kaustubh; Li, Dan; Li, Yi; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: WT , NIH | 3D Analysis of Normal Fac... (5U01DE020078-04), NWO | NCHA Subsidiebesluit 2008... (2300155116), NHMRC | Advancing our understandi... (1103623), NIH | The Genetic Architecture ... (5R01DE027023-02), EC | VISAGE (740580), NIH | Health outcomes and impro... (1R01DD000295-01), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | The genetics of human phy... (BB/I021213/1), NIH | Extending the Phenotype o... (5R01DE016148-12)

    <jats:title>Abstract</jats:title><jats:p>The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited despite the relevance for various fields of science and application. A series of genome-wide assoc...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Jeong Hyun Lee; Katie Doores; Jean-Philippe Julien;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Exploitation of Glycoarra... (EP/G037604/1), NIH | Center for HIV/AIDS Vacci... (3UM1AI100663-04S1), NIH | Technical Assistance to S... (Y1GM1104-15-0-1), EC | SHEV (280829), NIH | Immunogenic sugar moietie... (1U01CA128416-01), NIH | Neutralization of Primary... (5R37AI036082-19), NIH | Structure determination o... (5F32AI074372-03), CIHR , NIH | Center for AIDS Research (5P30AI036214-11), NIH | A SYNCHROTRON RADIATION B... (5P41RR001209-14),...

    New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates w...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Martin Davey; Stuart Hunter; Ester Remmerswaal; Sofya Kasatskaya;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Intrahepatic signals invo... (G1002552), WT | The molecular basis of ga... (099266)

    Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the Vδ2+ compartment comprises both innate-like and adaptive subsets. Vγ9+ Vδ2+ T cell...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Neil Gow; Alistair J P Brown; Karin Strijbis; Donna MacCallum;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | An invitro model system t... (NC/K50046X/1), EC | STRIFE (249793), EC | ARIADNE (237936), WT | The Candida albicans ORFe... (088858), RCUK | Combinatorial responses o... (BB/F00513X/1), WT | Candida albicans cell sur... (080088), EC | FINSYSB (214004), WT | Wellcome Strategic Award ... (097377)

    The major fungal pathogen of humans, Candida albicans, is exposed to reactive nitrogen and oxygen species following phagocytosis by host immune cells. In response to these toxins, this fungus activates potent anti-stress responses that include scavenging of reactive nit...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Sean Saunders; Alan D. Irvine; Padraic G. Fallon; WH McLean;
    Project: WT | Human and mouse genetics ... (092530), WT | The establishment of a la... (090066), RCUK | In vivo model systems to ... (G0700314)

    Background: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activity, we hypothesized an enhanced release of proinflammatory IL-1 cytoki...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Michuki Maina; Olga Tosas-Auguet; Jacob McKnight; Mathias Zosi; Grace Kimemia; Paul Mwaniki; Constance Schultsz; Mike English;
    Publisher: Public Library of Science (PLoS)
    Project: WT | Initiative to Develop Afr... (107769), WT , WT | Can a system intervention... (207522), RCUK | Infection Prevention and ... (ES/P004938/1)

    <p><strong>Background </strong>Water Sanitation and Hygiene (WASH) in healthcare facilities is critical in the provision of safe and quality care. Poor WASH increases hospital-associated infections and contributes to the rise of antimicrobial resistance (AMR). It is the...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Rashmi Patel; Matthew J Taylor; Robert James Stewart; Philip McGuire;
    Publisher: BMJ
    Project: RCUK | Predicting clinical and f... (MR/K002813/1)

    Objectives To investigate the association between antidepressant therapy and the later onset of mania/bipolar disorder.<br/><br/>Design Retrospective cohort study using an anonymised electronic health record case register.<br/><br/>Setting South London and Maudsley Nati...

220 research outcomes, page 1 of 22
Last index information