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142 research outcomes, page 1 of 15
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Lu, Meng; Banetta, Luca; Young, Laurence J; Smith, Edward J; Bates, Gillian P; Zaccone, Alessio; Kaminski, Gabriele; Tunnacliffe, Alan; Kaminski, Clemens;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: RCUK | Next generation live supe... (MR/K015850/1), EC | DRYLIFE (233232), RCUK | Development of single mol... (EP/H018301/1), WT | Mechanisms of neurotoxici... (089703), RCUK | MICA: Multi-parametric an... (MR/K02292X/1), RCUK | EPSRC Centre for Doctoral... (EP/L015889/1), WT

    : The mechanisms leading to self-assembly of misfolded proteins into amyloid aggregates have been studied extensively in the test tube under well-controlled conditions. However, to what extent these processes are representative of those in the cellular environment remai...

  • publication . Article . 2013
    Open Access English
    Authors:
    John Miles; David Cole; Andrew Sewell;
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: NIH | Physical Basis for T Cell... (5R01GM067079-09), RCUK | Comprehensive analysis of... (BB/H001085/1)

    The T-cell receptor (TCR) recognizes peptides bound to major histocompatibility molecules (MHC) and allows T-cells to interrogate the cellular proteome for internal anomalies from the cell surface. The TCR contacts both MHC and peptide in an interaction characterized by...

  • publication . Article . Other literature type . 2010
    Open Access English
    Authors:
    Cornelia de Moor;
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: RCUK | Cytoplasmic polyadenylati... (BB/G001847/1), WT

    3'-Deoxyadenosine, also known as cordycepin, is a known polyadenylation inhibitor with a large spectrum of biological activities, including anti-proliferative, pro-apoptotic and anti-inflammatory effects. In this study we confirm that cordycepin reduces the length of po...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Alexander Agrotis; Lucas von Chamier; Harriet Oliver; Koshiro Kiso; Tanya Singh; Robin Ketteler;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: RCUK | UKDP: Integrated DEmentiA... (MR/M02492X/1), WT , WT | Institutional Strategic S... (105604)

    : Microtubule-associated protein 1 light chain 3 α (LC3)/GABA type A receptor-associated protein (GABARAP) comprises a family of ubiquitin-like proteins involved in (macro)autophagy, an important intracellular degradation pathway that delivers cytoplasmic material to ly...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Ben A. Wagstaff; Martin Rejzek; Sakonwan Kuhaudomlarp; Lionel Hill; Ilaria Mascia; Sergey A. Nepogodiev; Helge C. Dorfmueller; Robert A. Field;
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: WT | Functional and structural... (109357), RCUK | Products and Pathways (BBS/E/J/000PR9790), WT

    <p>The 6-deoxy sugar l-rhamnose (l-Rha) is found widely in plant and microbial polysaccharides and natural products. The importance of this and related compounds in host-pathogen interactions often means that l-Rha plays an essential role in many organisms. l-Rha is mos...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Patrick Sexton; Juan Carlos Mobarec;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: NHMRC | The Janus Faces of G Prot... (1055134), NHMRC | Understanding the structu... (1061044), RCUK | Addressing the architectu... (BB/M006883/1)

    The glucagon-like peptide-1 receptor (GLP-1R) is a key therapeutic target in the management of type II diabetes mellitus, with actions including regulation of insulin biosynthesis and secretion, promotion of satiety, and preservation of β-cell mass. Like most class B G ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Benjamin T. McDermott; Mandy J. Peffers; Brian McDonagh; Simon R. Tew;
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: RCUK | Investigating the role of... (MR/N011333/1), RCUK | Defining the post-transcr... (BB/K00381X/1)

    Osteoarthritis is a chronic disease characterised by the loss of articular cartilage in synovial joints through a process of extracellular matrix destruction that is strongly associated with inflammatory stimuli. Chondrocytes undergo changes to their protein translation...

  • publication . Preprint . Other literature type . Article . 2020
    Open Access English
    Authors:
    Lockhart, Deborah E.A.; Stanley, Mathew; Raimi, Olawale G.; Robinson, David A.; Boldovjakova, Dominika; Squair, Daniel R.; Ferenbach, Andrew T.; Fang, Wenxia; van Aalten, Daan M.F.;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT , WT | Inhibition by proxy: targ... (105772), RCUK | Genetic, structural and c... (MR/M004139/1)

    <jats:p><jats:italic>Aspergillus fumigatus</jats:italic> is a human opportunistic fungal pathogen whose cell wall protects it from the extracellular environment including host defenses. Chitin, an essential component of the fungal cell wall, is synthesized from UDP-GlcN...

  • publication . Article . 2018
    Open Access English
    Authors:
    George Sutherland; Katie Grayson Steel; Nathan Adams; Andrew Hitchcock; Pierre Tuffery;
    Publisher: HAL CCSD
    Project: EC | ProteinFactory (642836), EC | SYNTHPHOTO (338895), NIH | BIOPHYSICAL SPECTROSCOPY ... (5T32GM008275-04), RCUK | Engineering new capacitie... (BB/M000265/1)

    : Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase (Tat). The Tat machinery exports folded and cofactor-containing proteins from the cytoplasm to the periplasm ...

  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Katie Smith;
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: RCUK | A study of the role of Kv... (BB/E023142/1)

    Mutations in KCNV2 have been proposed as the molecular basis for cone dystrophy with supernormal rod electroretinogram. KCNV2 codes for the modulatory voltage-gated potassium channel α-subunit, Kv8.2, which is incapable of forming functional channels on its own. Functio...

142 research outcomes, page 1 of 15
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