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398 research outcomes, page 1 of 40
  • publication . Article . 2016
    Open Access English
    Authors:
    Skirmantas Kriaucionis; Benjamin Schuster-Böckler;
    Project: EC | BLUEPRINT (282510), RCUK | Life Sciences Interface D... (EP/F500394/1), RCUK | Determining the contribut... (BB/M001873/1)

    CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T mutation rate in CpG sites has been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and plays a role in transcription silencing. ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    sara garbarino; Jonathan Schott; Frederik Barkhof; M. Arfan Ikram;
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | EuroPOND (666992), RCUK | Medical image computing f... (EP/M020533/1), CIHR

    <jats:p>The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approa...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    John Mullins; Helen Christian; Kirsty L Hassall; Hiroshi Momiji; David Spiller;
    Project: RCUK | Systems Biology analysis ... (BB/K003097/1), WT , RCUK | MICA: Imaging of cellular... (MR/K015885/1)

    Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over time, as opposed to ...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Christopher D Todd; Özgen Deniz; Darren Taylor; Miguel R Branco;
    Publisher: eLife Sciences Publications, Ltd
    Project: WT , WT | Epigenetic control of ret... (101225), RCUK | Novel approaches for epig... (BB/R505997/1)

    Transposable elements (TEs) are thought to have helped establish gene regulatory networks. Both the embryonic and extraembryonic lineages of the early mouse embryo have seemingly co-opted TEs as enhancers, but there is little evidence that they play significant roles in...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Fernanda Bajanca; Eric Theveneau;
    Publisher: eLife Sciences Publications, Ltd
    Project: EC | QUESTFORMD (253305), RCUK | Somitic muscle growth: a ... (G1001029)

    Dystrophin forms an essential link between sarcolemma and cytoskeleton, perturbation of which causes muscular dystrophy. We analysed Dystrophin binding dynamics in vivo for the first time. Within maturing fibres of host zebrafish embryos, our analysis reveals a pool of ...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Jalal, Adam S. B.; Tran, Ngat T.; Le, Tung B. K.;
    Publisher: eLife Sciences Publications, Ltd
    Project: RCUK | Biological Context (BBS/E/J/000PR9791), RCUK | How does Structural Maint... (BB/P018165/1)

    <jats:title>ABSTRACT</jats:title><jats:p>In all living organisms, it is essential to transmit genetic information faithfully to the next generation. The SMC-ParAB-<jats:italic>parS</jats:italic> system is widely employed for chromosome segregation in bacteria. A DNA-bin...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Agata Wesolowska-Andersen; Grace Zhuo Yu; Vibe Nylander; Fernando Abaitua; Matthias Thurner; Jason Torres; Anubha Mahajan; Anna L Gloyn; Mark I McCarthy;
    Project: NIH | Identifying variants caus... (5U01DK085545-02), NIH | Integrating genome-scale ... (1U01DK105535-01), EC | T2DSystems (667191), WT | Human Genetics and Diseas... (203141), WT | Characterising causal all... (098381), WT | Understanding the genetic... (090532), RCUK | Defining the molecular an... (MR/L020149/1), WT | Genomic Medicine and Stat... (099673), WT | Bridging the gap from typ... (095101), WT | Large-scale data integrat... (212259),...

    <jats:title>Abstract</jats:title><jats:p>Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a challenge. There is growing interest in the potential of deep learning mod...

  • publication . Article . Preprint . Conference object . Other literature type . 2017
    Open Access
    Authors:
    Juusola, Mikko; Dau, An; Song, Zhuoyi; Solanki, Narendra; Rien, Diana; Jaciuch, David; Dongre, Sidhartha Anil; Blanchard, Florence; de Polavieja, Gonzalo G; Hardie, Roger C; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: RCUK | The effect of feedback co... (BB/D001900/1), RCUK | How does the Drosophila b... (BB/F012071/1), RCUK | Reverse-engineering Droso... (BB/H013849/1), RCUK | Phosphoinositide cycle in... (BB/M007006/1)

    Small fly eyes should not see fine image details. Because flies exhibit saccadic visual behaviors and their compound eyes have relatively few ommatidia (sampling points), their photoreceptors would be expected to generate blurry and coarse retinal images of the world. H...

  • publication . Article . 2015
    Open Access English
    Authors:
    Sonja-Verena Albers; Fabian Blombach; Katherine Smollett; Finn Werner; Carol Sheppard; Enrico Salvadori; Christopher Kay;
    Publisher: eLife Sciences Publications, Ltd
    Project: WT | Regulation of transcripti... (079351), RCUK | Functional and biophysica... (BB/H019332/1), WT

    eLife digest Life on Earth is often categorized into three domains: the eukaryotes (which include plants, animals and fungi), the bacteria and a group of unusual, single-celled microorganisms called the archaea. But several recent discoveries suggest that the origin of ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Thomas Crellen; Paul Turner; Sreymom Pol; Stephen Baker; To Nguyen Thi Nguyen; Nicole Stoesser; Nicholas PJ Day; Claudia Turner; Ben S Cooper;
    Project: WT | Thailand Major Overseas P... (106698), WT , RCUK | Developing and evaluating... (MR/K006924/1)

    <jats:p>Multidrug-resistant Klebsiella pneumoniae is an increasing cause of infant mortality in developing countries. We aimed to develop a quantitative understanding of the drivers of this epidemic by estimating the effects of antibiotics on nosocomial transmission ris...

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