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271 research outcomes, page 1 of 28
  • publication . Article . 2015
    Open Access
    Authors:
    Wael Abdel-Fattah; Mark Helm; Stark, M. J. R.; Alexander Hammermeister; Rachael Di Santo;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | A comprehensive analysis ... (BB/F019106/1), WT | Centre for Gene Regulatio... (083524)

    Author Summary tRNA molecules function as adapters in protein synthesis, bringing amino acids to the ribosome and reading the genetic code through codon-anticodon base pairing. When the tRNA contains a uridine residue in the “wobble position” of its anticodon, which bas...

  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Panos Deloukas; Ruth Loos; Gregory Livshits; Ines Barroso; Fernando Rivadeneira; Nicole Soranzo; Eleanor Wheeler; Frances Williams;
    Publisher: Public Library of Science (PLoS)
    Project: WT | A national DNA control se... (068545), CIHR , RCUK | Assessment of biomedical ... (G0000934)

    Author Summary The first genetic association studies of adult height have confirmed a role of many common variants in influencing human height, but to date, the genetic basis of differences between different skeletal components of height have not been addressed. Here, w...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Christa Meisinger; Tiinamaija Tuomi; Josee Dupuis; Marit Eika Jørgensen; João Fadista; Alexander Doney; stephen o'rahilly; Jianjun Liu; E Shyong Tai; Gemma Buck; ...
    Publisher: Public Library of Science (PLoS)
    Project: WT | LRRK2 modulation of Wnt s... (095010), WT | Statistical methods for t... (098017), EC | ENGAGE (201413), WT | Scottish Health Informati... (086113), NIH | Targeted Genetic Analysis... (2R01DK072193-10), EC | PREPOBEDIA (201681), NIH | Genetic epidemiology of r... (3R01DK093757-05S1), AKA | The Application of 'Omics... (139635), NIH | Genetic analysis of type ... (1Z01HG000024-09), WT | Characterising causal all... (098381),...

    Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Roque, Helio; Saurya, Saroj; Pratt, Metta B.; Johnson, Errin; Raff, Jordan W.;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | The Oxford Consortium for... (BB/L014122/1), WT , WT | Micron Oxford: super-reso... (107457), WT | A molecular analysis of c... (104575)

    Pericentrin is a conserved centrosomal protein whose dysfunction has been linked to several human diseases. It has been implicated in many aspects of centrosome and cilia function, but its precise role is unclear. Here, we examine Drosophila Pericentrin-like-protein (PL...

  • publication . Article . 2014
    Open Access
    Authors:
    Svetlana Makovets;
    Publisher: Public Library of Science (PLoS)
    Project: WT , RCUK | Molecular pathways that c... (G0900500)

    Broken replication forks result in DNA breaks that are normally repaired via homologous recombination or break induced replication (BIR). Mild insufficiency in the replicative ligase Cdc9 in budding yeast Saccharomyces cerevisiae resulted in a population of cells with p...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Censin, Jenny C.; Peters, Sanne A. E.; Bovijn, Jonas; Ferreira, Teresa; Pulit, Sara L.; Mägi, Reedik; Mahajan, Anubha; Holmes, Michael V.; Lindgren, Cecilia M.;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Sex differences in the va... (MR/P014550/1), NIH | GPCRS in the Neuroendocri... (5P50HD028138-25), EC | WIDENLIFE (692065), WT | Human Genetics and Diseas... (203141)

    Author summary Obesity is increasing globally and has been linked to major causes of death, such as diabetes and heart disease. Still, the causal effects of obesity on other leading causes of death is relatively unexplored. It is also unclear if any such effects differ ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Claessens, Antoine; Harris, Lynne M; Stanojcic, Slavica; Chappell, Lia; Stanton, Adam; Kuk, Nada; Veneziano-Broccia, Pamela; Sterkers, Yvon; Rayner, Julian; Merrick, Catherine;
    Publisher: HAL CCSD
    Project: WT , RCUK | Virulence gene dynamics i... (MR/L008823/1), RCUK | Virulence gene dynamics i... (MR/K000535/1)

    Author summary Human malaria is caused by Plasmodium parasites, with most of the mortality (almost half a million deaths each year) being caused by one species, Plasmodium falciparum. This parasite has an unusual genome: it is exceptionally biased towards A and T nucleo...

  • publication . Article . 2014
    Open Access
    Authors:
    Eugene Schuster; Barbara Jennings;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Regulation of Development... (G0800310), WT | Molecular mechanisms of r... (090021), RCUK | A detailed network of tra... (G0800339)

    Author Summary Repression by transcription factors plays a central role in gene regulation. The Groucho/Transducin-Like Enhancer of split (Gro/TLE) family of co-repressors interacts with many different transcription factors and has many essential roles during animal dev...

  • publication . Article . 2015
    Open Access English
    Authors:
    Mariona Graupera; Guillaume Halet; Lee B. Smith; Philippa Saunders; claude chelala; John Graham Carroll; Julie Guillermet-Guibert;
    Publisher: Public Library of Science (PLoS)
    Project: EC | PACA/PI3K (270696), RCUK | Generic and hormonal dete... (G1100354)

    The organismal roles of the ubiquitously expressed class I PI3K isoform p110β remain largely unknown. Using a new kinase-dead knockin mouse model that mimics constitutive pharmacological inactivation of p110β, we document that full inactivation of p110β leads to embryon...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Wendy Bickmore; Kate Storey;
    Publisher: Public Library of Science (PLoS)
    Project: EC | FUNCTIONALEDGE (249956), RCUK | An alternative retinoid p... (G1100552), WT | Cell behaviour and signal... (083611)

    Changes in higher order chromatin organisation have been linked to transcriptional regulation; however, little is known about how such organisation alters during embryonic development or how it is regulated by extrinsic signals. Here we analyse changes in chromatin orga...

271 research outcomes, page 1 of 28
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