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397 research outcomes, page 1 of 40
  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Qing Jun Meng;
    Publisher: Oxford University Press (OUP)
    Project: WT , RCUK | Common epigenetic pathway... (G0900414)

    Post-translational modifications (such as ubiquitination) of clock proteins are critical in maintaining the precision and robustness of the evolutionarily conserved circadian clock. Ubiquitination of the core clock transcription factor BMAL1 (brain and muscle Arnt-like ...

  • publication . Article . 2013
    Open Access
    Authors:
    Daniel Vaughan; Alex Mitchell; Maxim Scheremetjew; Alejandra Gonzalez-Beltran; Matthew Fraser; Chris Hunter; Peter Sterk; Guy Cochrane; Denise H; Sarah Hunter; ...
    Project: RCUK | 'Omics Data Sharing: the ... (BB/I000771/1), EC | MICRO B3 (287589), RCUK | Building a global metagen... (BB/I025840/1), RCUK | Building a global metagen... (BB/I02612X/1), WT

    Metagenomics is a relatively recently established but rapidly expanding field that uses high-throughput next-generation sequencing technologies to characterize the microbial communities inhabiting different ecosystems (including oceans, lakes, soil, tundra, plants and b...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Eugene Kulesha;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | Structural classification... (MC_U105192716), RCUK | GENOME-3D: a UK network p... (BB/I024917/1)

    We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Simil...

  • publication . Conference object . Article . Other literature type . 2017
    Open Access
    Authors:
    Dehghani-Tafti, Saba; Sanders, Cyril M.;
    Project: RCUK | Opening of a double stran... (BB/K019252/1), RCUK | A quantitative biomolecul... (BB/L013851/1)

    Abstract UPF1 is a conserved helicase required for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm. Human UPF1 (hUPF1) is also needed for nuclear DNA replication. While loss of NMD is tolerated, loss of hUPF1 induces a DNA damage response and ce...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Antonella Spinazzola; ian holt; Johannes Spelbrink; Aurelio Reyes;
    Project: NWO | Our other genome: organiz... (2300157753), RCUK | Energy production and mit... (MC_U105663140)

    Abstract Mammalian mitochondria operate multiple mechanisms of DNA replication. In many cells and tissues a strand-asynchronous mechanism predominates over coupled leading and lagging-strand DNA synthesis. However, little is known of the factors that control or influenc...

  • publication . Other literature type . Article . 2011 . Embargo End Date: 11 Apr 2017
    Open Access English
    Authors:
    Blackwood, JK; Rzechorzek, Neil; Abrams, AS; Maman, Joseph; Pellegrini, Luca; Robinson, Nick;
    Publisher: Apollo - University of Cambridge Repository
    Project: RCUK | An investigation of DNA r... (G0701443), WT

    Helicase-nuclease systems dedicated to DNA end resection in preparation for homologous recombination (HR) are present in all kingdoms of life. In thermophilic archaea, the HerA helicase and NurA nuclease cooperate with the highly conserved Mre11 and Rad50 proteins durin...

  • publication . Article . 2017
    Open Access English
    Authors:
    Darren Matthew Gowers; Andy Pickford; Paul Cox;
    Publisher: Oxford University Press
    Project: RCUK | Investigating metabolite-... (BB/J016179/1)

    Abstract Ribonucleases play essential roles in all aspects of RNA metabolism, including the coordination of post-transcriptional gene regulation that allows organisms to respond to internal changes and environmental stimuli. However, as inherently destructive enzymes, t...

  • publication . Conference object . Article . 2014
    Open Access
    Authors:
    Ian Mickleburgh; Stephen Curry;
    Project: WT | Mechanisms of alternative... (092900), RCUK | Mapping PTB interactions ... (BB/H004203/1), WT | Single molecule tools for... (088113)

    : Post-transcriptional steps of gene expression are regulated by RNA binding proteins. Major progress has been made in characterizing RNA-protein interactions, from high resolution structures to transcriptome-wide profiling. Due to the inherent technical challenges, les...

  • publication . Conference object . Article . 2014
    Open Access
    Authors:
    Nicolas Joly; Vidya Darbari; Xiaodong Zhang;
    Project: RCUK | Biological functions that... (BB/J002828/1), WT | Regulation of an RNA poly... (093044), RCUK | Geometric requirements fo... (BB/G001278/1), RCUK | Mechanism of a nucleotide... (BB/H012249/1)

    Binding and hydrolysis of ATP is universally required by AAA+ proteins to underpin their mechano-chemical work. Here we explore the roles of the ATPase site in an AAA+ transcriptional activator protein, the phage shock protein F (PspF), by specifically altering the Walk...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Brandon Walts; Emily Perry; Benjamin Moore; Matthieu Muffato; Fiona Cunningham; Laurent Gil; Premanand Achuthan; Andrew D Yates; Erin Haskell; Jyothish Bhai; ...
    Publisher: Oxford University Press (OUP)
    Project: EC | MultipleMS (733161), WT | The Genome Campus Allianc... (201535), WT | Designing, developing and... (200990), RCUK | Ensembl genome portal for... (BB/M011615/1), NIH | GWAS Catalog (1U41HG007823-01), RCUK | ProteoGenomics: Dynamic L... (BB/L024225/1), WT | ENSEMBL (108749), EC | MedBioinformatics (634143), NIH | GENCODE: comprehensive ge... (5U41HG007234-04), WT | The International Genome ... (104947)

    Abstract The Ensembl project has been aggregating, processing, integrating and redistributing genomic datasets since the initial releases of the draft human genome, with the aim of accelerating genomics research through rapid open distribution of public data. Large amou...

397 research outcomes, page 1 of 40
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