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206 research outcomes, page 1 of 21
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Juan J. Cáceres; Alberto Paccanaro;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Bilateral NSF/BIO-BBSRC -... (BB/M025047/1), RCUK | A GPU-based high performa... (BB/K004131/1), RCUK | Development of a graph-th... (BB/F00964X/1)

    Author summary The elucidation of the genetic causes of diseases is central to understanding the mechanisms of action of a pathology and the development of treatments. Disease gene prediction methods streamline the discovery of the molecular basis for a disease by prior...

  • publication . Article . 2013
    Open Access English
    Authors:
    Sam Brown; Richard Goldstein;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | SANDPIT: Multi-scale dyna... (EP/H032436/1), WT | Evolutionary Ecology of M... (082273)

    The repression of competition by mechanisms of policing is now recognized as a major force in the maintenance of cooperation. General models on the evolution of policing have focused on the interplay between individual competitiveness and mutual policing, demonstrating ...

  • publication . Article . 2016
    Open Access
    Authors:
    Song Feng; Julien F. Ollivier; Orkun S. Soyer;
    Project: RCUK | Engineering a semi-biotic... (EP/H04986X/1)

    Signalling networks result from combinatorial interactions among many enzymes and scaffolding proteins. These complex systems generate response dynamics that are often essential for correct decision-making in cells. Uncovering biochemical design principles that underpin...

  • publication . Article . 2011
    Open Access English
    Authors:
    Aitken, Stuart; Alexander, Ross D.; Beggs, Jean D.;
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: RCUK | Centre for Systems Biolog... (BB/D019621/1), WT

    Author Summary The coding information for the synthesis of proteins in mammalian cells is first transcribed from DNA to messenger RNA (mRNA), before being translated from mRNA to protein. Each step is complex, and subject to regulation. Certain sequences of DNA must be ...

  • publication . Article . 2014
    Open Access
    Authors:
    Jose A. Seoane; Tom Gaunt;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | A systems approach to the... (G1000427)

    Genome-wide association studies have identified a wealth of genetic variants involved in complex traits and multifactorial diseases. There is now considerable interest in testing variants for association with multiple phenotypes (pleiotropy) and for testing multiple var...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Katy Gaythorpe; Kévin Jean;
    Project: RCUK | MRC Centre for Global Inf... (MR/R015600/1)

    Yellow fever is a vector-borne disease endemic in tropical regions of Africa, where 90% of the global burden occurs, and Latin America. It is notoriously under-reported with uncertainty arising from a complex transmission cycle including a sylvatic reservoir and non-spe...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Vijayabaskar, MS; Goode, Debbie K; Obier, Nadine; Lichtinger, Monika; Emmett, Amber ML; Abidin, Fatin N Zainul; Shar, Nisar; Hannah, Rebecca; Assi, Salam A; Lie-A-Ling, Michael; ...
    Publisher: Public Library of Science (PLoS)
    Project: WT , RCUK | Infrastructure for collab... (MR/L01629X/1), RCUK | Establishment of the haem... (BB/I001794/1), RCUK | DECIPHERING THE BIOLOGICA... (MR/P000673/1), RCUK | Establishment of the haem... (BB/I001220/1)

    Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these processes genome-wide, leading to large datasets t...

  • publication . Article . Preprint . 2018
    Open Access
    Authors:
    Harrison, Jonathan U.; Baker, Ruth E.;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Next generation approache... (BB/R000816/1), RCUK | Systems Biology Doctoral ... (EP/G03706X/1)

    Imaging data has become an essential tool to explore key biological questions at various scales, for example the motile behaviour of bacteria or the transport of mRNA, and it has the potential to transform our understanding of important transport mechanisms. Often these...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Ge Tan; Dimitris Polychronopoulos; Boris Lenhard;
    Publisher: Public Library of Science
    Project: RCUK | Computational Regulatory ... (MC_UP_1102/1), WT | The core promoter: an une... (106954), WT , EC | ZF-HEALTH (242048)

    <jats:title>Abstract</jats:title><jats:p>Conserved Noncoding Elements (CNEs) are elements exhibiting extreme noncoding conservation in Metazoan genomes. They cluster around developmental genes and act as long-range enhancers, yet nothing that we know about their functio...

  • publication . Article . 2020
    Open Access
    Authors:
    Foo, Mathias; Bates, Declan G.; Akman, Ozgur E.;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | The Parameter Optimisatio... (EP/N017846/1), RCUK | EPSRC Centre for Predicti... (EP/N014391/1), RCUK | Warwick Integrative Synth... (BB/M017982/1)

    Author summary Mathematical models have been widely employed as a complement to experimental work in elucidating the underlying mechanistic behaviour of the plant circadian clock. In this study, we investigate the use of a simplified modelling strategy, the S-System fra...

206 research outcomes, page 1 of 21
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