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188 research outcomes, page 1 of 19
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ritchie, Neil D.; Ritchie, Ryan; Bayes, Hannah K.; Mitchell, Tim J.; Evans, Tom J.;
    Publisher: Public Library of Science
    Project: WT , RCUK | The role of Th17 immunity... (G1001998), WT | Scottish Consortium, Tran... (094779)

    Author summary Streptococcus pneumoniae (the pneumococcus) is an important human pathogen and the commonest cause of community-acquired pneumonia. The bacterial carbohydrate capsule is a key determinant of virulence and host defence. Pneumonia follows colonization of th...

  • publication . Article . 2016
    Open Access English
    Authors:
    Graham P Taylor; Lucy Cook; Aileen Rowan; Anat Melamed; Charles Bangham;
    Publisher: Public Library of Science
    Project: RCUK | Regulation of clonality i... (MR/K019090/1), WT , WT | Regulation of retroviral ... (100291)

    There is growing evidence that CD8+ cytotoxic T lymphocyte (CTL) responses can contribute to long-term remission of many malignancies. The etiological agent of adult T-cell leukemia/lymphoma (ATL), human T lymphotropic virus type-1 (HTLV-1), contains highly immunogenic ...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Jeong Hyun Lee; Katie Doores; Jean-Philippe Julien;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Exploitation of Glycoarra... (EP/G037604/1), NIH | Center for HIV/AIDS Vacci... (3UM1AI100663-04S1), NIH | Technical Assistance to S... (Y1GM1104-15-0-1), EC | SHEV (280829), NIH | Immunogenic sugar moietie... (1U01CA128416-01), NIH | Neutralization of Primary... (5R37AI036082-19), NIH | Structure determination o... (5F32AI074372-03), CIHR , NIH | Center for AIDS Research (5P30AI036214-11), NIH | A SYNCHROTRON RADIATION B... (5P41RR001209-14),...

    New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates w...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Fillol-Salom, Alfred; Alsaadi, Ahlam; de Sousa, Jorge A. Moura; Zhong, Li; Foster, Kevin R.; Rocha, Eduardo P. C.; Penadés, José R.; Ingmer, Hanne; Haaber, Jakob;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Helper and satellite path... (BB/S003835/1), RCUK | Molecular biology of the ... (MR/M003876/1), WT | Understanding and enginee... (209397), EC | DUT-signal (670932), EC | MicroWars (787932), RCUK | Deciphering Gram-negative... (MR/S00940X/1), WT | Understanding bacterial h... (201531)

    Temperate phages are bacterial viruses that as part of their life cycle reside in the bacterial genome as prophages. They are found in many species including most clinical strains of the human pathogens, Staphylococcus aureus and Salmonella enterica serovar Typhimurium....

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Albert Osterhaus; Rory de Vries; W Paul Duprex; Rik L. de Swart;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Illuminating childhood re... (G0801001)

    Measles remains a significant childhood disease, and is associated with a transient immune suppression. Paradoxically, measles virus (MV) infection also induces robust MV-specific immune responses. Current hypotheses for the mechanism underlying measles immune suppressi...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Daniel Mair; Connor Bamford; Inês Filipe; Elihu Aranday-Cortes;
    Publisher: Public Library of Science
    Project: NIH | Diversifying interferon f... (4K01CA175127-04), RCUK | Viral Hepatitis (MC_UU_12014/1), NIH | Integrative nutrigenomic ... (5R01DK104339-03), NIH | Integrative Genomics of B... (1R01GM113657-01)

    As antimicrobial signalling molecules, type III or lambda interferons (IFNλs) are critical for defence against infection by diverse pathogens, including bacteria, fungi and viruses. Counter-intuitively, expression of one member of the family, IFNλ4, is associated with d...

  • publication . Article . 2011
    Open Access
    Authors:
    Magda Atilano; Sergio Filipe; James Yates;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Investigating pathogen re... (G0300170), WT | Candida albicans infectio... (087680), FCT | SFRH/BD/28440/2006 (SFRH/BD/28440/2006), FCT | PTDC/SAU-MII/75696/2006 (75696), FCT | SFRH/BPD/23838/2005 (SFRH/BPD/23838/2005), FCT | PTDC/BIA-MIC/100747/2008 (100747)

    The cell wall of Gram-positive bacteria is a complex network of surface proteins, capsular polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    David Sychantha; Carys S. Jones; Dustin J. Little; Patrick J. Moynihan; Howard Robinson; Nicola F. Galley; David I. Roper; Christopher G. Dowson; P. Lynne Howell; Anthony J. Clarke;
    Publisher: Public Library of Science
    Project: CIHR , RCUK | Team CanUK: Novel antibac... (G1100127)

    Author summary Multi-drug resistance amongst important human pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE) and drug-resistant Streptococcus pneumoniae (DRSP), continues to challenge clinicians and threaten...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Orin Courtenay; Nathan C. Peters; Matthew E. Rogers; Caryn Bern;
    Publisher: Public Library of Science
    Project: RCUK | Dissecting and exploiting... (BB/H022406/1), WT , CIHR

    Author summary We review recent research that sheds light on the quantitative biology of leishmanial transmission between sand flies and mammalian hosts and use these insights to better understand transmission, the observed epidemiology of the disease, and their implica...

  • publication . Article . 2016
    Open Access English
    Authors:
    Fabio Gsaller; Peter Hortschansky; Takanori Furukawa; Paul D Carr; Bharat Rash; Javier Capilla; Christoph Müller; Franz Bracher; Paul Bowyer; Hubertus Haas; ...
    Publisher: Public Library of Science
    Project: RCUK | A genome-scale census of ... (MR/M02010X/1)

    [This corrects the article DOI: 10.1371/journal.ppat.1005775.].

188 research outcomes, page 1 of 19
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