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76 research outcomes, page 1 of 8
  • publication . Conference object . Article . Other literature type . Preprint . 2015
    Open Access
    Authors:
    Sylvia Richardson; Hui Guo; Antony Cutler; deborah smyth; Neil Walker; Stephen Sawcer; Nikolas Pontikos; Chris Wallace; Oliver Burren;
    Project: WT | Diabetes and Inflammation... (091157), WT , RCUK | Assessment of biomedical ... (G0000934), WT | The genetics of weight, B... (076113), WT | A national DNA control se... (068545), WT | Genes and Pathways in Typ... (089989), EC | NAIMIT (241447), WT | Cellular Medicine at the ... (100140), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01)

    Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD) and multiple association signals. Nonetheless, accurate maps of these variants are needed, both to fully exploit detailed cell sp...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Obeidat, Ma'en; Hao, Ke; Bossé, Yohan; Nickle, David C; Nie, Yunlong; Postma, Dirkje S; Laviolette, Michel; Sandford, Andrew J; Daley, Denise D; Hogg, James C; ...
    Project: AKA | GENETIC REGULATION OF THE... (120315), AKA | CoE in Complex Disease Ge... (213506), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | GWA for Gene-Environment ... (5U01HG004402-02), RCUK | Centre for molecular-base... (G0600705), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | A Genome-Wide Association... (5R01HL086694-05), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), NIH | Epidemiology of Venous Th... (5R01HL059367-10), AKA | Well-being and health: Re... (104781),...

    SummaryBackgroundLung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Steve E Humphries; Karin Leander; Ross Laxton; Rebecca Hardy; Barbara Jefferis; Mika Kivimaki; Shu Ye; John Deanfield; Bruna Gigante; Chris Wallace; ...
    Publisher: Oxford University Press
    Project: RCUK | Vitamin D and health: gen... (G0601653), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), RCUK | Assessment of biomedical ... (G0000934), EC | PHASE (223004), WT | A national DNA control se... (068545), RCUK | The MRC British Genetics ... (G9521010), WT | The genetics of weight, B... (076113), NIH | SOCIAL AND OCCUPATIONAL I... (5R01HL036310-09)

    Aims: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)- associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived ...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Udo Seedorf; Matthew Traylor; Joanna Pera; Panos Deloukas; Bo Norrving; Matthew A Brown; Julia Slark; John Attia; Caroline Jackson; Lee Murphy; ...
    Project: WT | A national DNA control se... (068545), RCUK | Assessment of biomedical ... (G0000934), WT | WTCCC2 core activities (085475), WT | A genome wide association... (084724)

    Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. ...

  • publication . Article . 2010
    Open Access English
    Authors:
    Anne Barton; Lucy Wedderburn; Paul Martin; Stephen Eyre; Lynne J Hocking / Mennie; Jane Worthington; Wendy Thomson; Anne Hinks; Pille Harrison;
    Publisher: Nature Publishing Group
    Project: RCUK | Assessment of biomedical ... (G0000934), WT | A national DNA control se... (068545)

    Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic arthritis (JIA) suscep...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Patrick Concannon; Soumya Raychaudhuri;
    Publisher: Public Library of Science
    Project: NIH | Fine-mapping the MHC asso... (1R01AR062886-01), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), RCUK | Assessment of biomedical ... (G0000934), WT | A national DNA control se... (068545), NIH | Bioinformatics and Popula... (1K08AR055688-01A1)

    DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, however, to collect genotyping data in large cohor...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Wilk, Jemma B.; Shrine, Nick R. G.; Loehr, Laura R.; Zhao, Jing Hua; Manichaikul, Ani; Lopez, Lorna M.; Smith, Albert Vernon; Heckbert, Susan R.; Smolonska, Joanna; Tang, Wenbo; ...
    Publisher: AMER THORACIC SOC
    Project: NIH | DYNAMICS OF HEALTH .AGING... (N01AG062101-015), NIH | CLINICAL COORDINATING CEN... (N01HR076119-002), NIH | CLINICAL CENTER FOR THE L... (N01HR076101-006), NIH | Approaches to Identify Ra... (5K08HL097029-04), NIH | Epidemiology of Venous Th... (5R01HL059367-10), NIH | CARDIOVASCULAR HEALTH STU... (N01HC035129-010), NIH | Genome-wide and Linkage S... (1RC1HL100543-01), WT | A second-generation genom... (084703), NIH | Genetic And Environmental... (1Z01ES043012-07), SNSF | SAPALDIA COHORT STUDY: Mo... (32473B-104288),...

    RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologi...

  • publication . Other literature type . Article . Conference object . 2016
    Open Access
    Authors:
    Stephen Eyre; Jonathan Massey; Wenhua Wei;
    Publisher: Springer Science and Business Media LLC
    Project: EC | BTCURE (115142), RCUK | Assessment of biomedical ... (G0000934), NIH | Genes and Phenotype (GAP)... (5RC2AR059092-02), NIH | Mapping Autoimmune Phenot... (3R01AI068759-03S1), NIH | Fine-mapping the MHC asso... (1R01AR062886-01), WT | A national DNA control se... (068545), WT | The genetics of weight, B... (076113), NIH | Bioinformatics and Popula... (1K08AR055688-01A1)

    Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS applicable to diseases: firstly using a mixed model approach t...

  • publication . Conference object . Article . 2011
    Open Access
    Authors:
    Joanna Howson; Chris Wallace; Neil Walker; deborah smyth;
    Project: WT | A national DNA control se... (068545), RCUK | Assessment of biomedical ... (G0000934), WT | The genetics of weight, B... (076113), WT | Genes and Pathways in Typ... (089989), WT | Cambridge Institute for M... (079895)

    Background The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D his...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Stephanie London; Ashish Kumar; Deborah Jarvis; Laura Loehr; Rachel Nadif; Adaikalavan Ramasamy; Gian Andri Thun; Florian Kronenberg; George T O'Connor; Dana Hancock; ...
    Publisher: HAL CCSD
    Project: NIH | COMMUNITY BASED STUDY ON ... (5R01HL062633-02), NIH | Genome-Wide Association f... (5R01HL087641-02), RCUK | Assessment of biomedical ... (G0000934), SNSF | The SAPALDIA II Cohort St... (3247-065896), NIH | Epidemiology of Venous Th... (5R01HL059367-10), WT | The genetics of weight, B... (076113), SNSF | SAPALDIA COHORT STUDY: Im... (32473B-104283), SNSF | Swiss study on air pollut... (4026-028099), WT | A second-generation genom... (084703), SNSF | SAPALDIA COHORT STUDY: Im... (32473B-104284),...

    Background: Genome-wide association studies have identified determinants of chronic obstructive pulmonary disease, asthma, and lung function level; however, none have addressed decline in lung function. Objective: We conducted the first genome-wide association study on ...

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