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66 research outcomes, page 1 of 7
  • publication . Article . Other literature type . Conference object . 2017
    Open Access English
    Authors:
    Thomas Foltynie; Eduardo De Pablo-Fernández; Patrick Lewis; George Davey Smith; Neil Pearce; Alastair Noyce; Debbie Lawlor; Nicholas Wood; Gibran Hemani;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Discovery of Rare Variant... (1P50NS071674-01), NIH | Parkinson Disease Collabo... (2R01NS037167-06), NIH | PD GWAS Consortium (1R01CA141668-01), NIH | Prospective studies on Pa... (1Z01ES101986-03), RCUK | Determining the genetic a... (G1100643), RCUK | Dissecting the role of LR... (MR/L010933/1), EC | MARKMD (230596), RCUK | Genome wide analysis of Y... (G0700943), WT | WTCCC3 core activities. (090355), RCUK | Understanding the genes f... (MR/N026004/1),...

    Background Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse...

  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Philippe Amouyel; Hans Scheffer; maria martinez; Panos Deloukas; Roger Alistair Barker; Alexis Brice; Claudia Schulte; Honglei Chen; Günther Deuschl; Sarah Edkins; ...
    Project: EC | MARKMD (230596), NIH | Washington University Ins... (3UL1RR024992-03S4), RCUK | Genome wide analysis of Y... (G0700943), NIH | Washington University Cen... (5P30NS057105-02), RCUK | Mapping the genetic archi... (G0901254), NIH | Prospective studies on Pa... (1Z01ES101986-03), WT | WTCCC2 core activities (085475), WT | A systematic investigatio... (089698), NIH | Genome wide SNP analysis ... (1Z01AG000949-01)

    Author Summary This paper describes the largest case-control analysis of Parkinson's disease to date, with a combined sample set of over 12,000 cases and 21,000 controls. After combining our findings with an independent replication dataset of more than 3,000 cases and 2...

  • publication . Article . 2013
    Open Access English
    Authors:
    Oliver S P Davis; Emma Meaburn; Claire Haworth; Maciej Trzaskowski; Thomas Price; Robert Plomin;
    Publisher: Public Library of Science
    Project: NIH | Genetics, School environm... (1R01HD044454-01A2), NIH | GENETICS OF GENERAL AND S... (5R01HD046167-02), WT | Identifying patterns of g... (088984), WT | WTCCC2 core activities (085475), RCUK | Origins of learning diffi... (G0500079)

    Background: \ud Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects. For this reason, in an attempt to identify genes responsible for these effects, we investigated domain-genera...

  • publication . Article . Other literature type . 2013
    Open Access
    Authors:
    Céline Bellenguez; Panos Deloukas; Matthew S. Gillman; Robert Plomin; Christopher Mathew; Craig Nagoshi;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | GENETICS OF GENERAL AND S... (5R01HD046167-02), EC | GHCA (295366), NIH | Genetics of Mathematical ... (5R01HD059215-05), NIH | Genetics, School environm... (1R01HD044454-01A2), WT | WTCCC2 core activities (085475), RCUK | Origins of learning diffi... (G0500079)

    The consequence of reduced cognitive ability from inbreeding has long been investigated, mainly restricted to cousin–cousin marriages. Molecular genetic techniques now allow us to test the relationship between increased ancestral inbreeding and cognitive ability in a po...

  • publication . Article . 2013
    Open Access English
    Authors:
    Jolanta Lissowska; Carlotta Sacerdote; Fredrick Schumacher; Christine Friedenreich; Sara Olson; Veronica Setiawan; Jirong Long; Marta Crous-Bou; Amanda Spurdle; Alison Margaret Dunning; ...
    Publisher: Springer Berlin Heidelberg
    Project: NIH | GENOTYPE/HORMONE INTERACT... (5P01CA077596-04), RCUK | Assessment of biomedical ... (G0000934), NIH | Shanghai Breast Cancer St... (3R01CA064277-05S1), NIH | Genome-Wide Association S... (5R01CA134958-02), NIH | GENETIC SUSCEPTIBILITY TO... (5R01CA082838-04), NIH | Towards a Mouse Model of ... (5R01CA098285-07), NIH | ESTROGEN, DIET, GENETICS ... (5R01CA083918-04), NHMRC | Molecular Epidemiology of... (339435), WT | A national DNA control se... (068545), NIH | Genetic Variation in Estr... (5R03CA128008-02),...

    Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggestin...

  • publication . Article . 2017
    Open Access English
    Authors:
    Jansen, IE; Ye, H; Heetveld, S; Lechler, MC; Michels, H; Seinstra, RI; Lubbe, SJ; Drouet, V; Lesage, S; Majounie, E; ...
    Publisher: BioMed Central
    Project: WT | WTCCC2 core activities (085475), EC | MARKMD (230596), NIH | Assessment of Candidate L... (1Z01AG000957-03), NIH | Prospective studies on Pa... (1Z01ES101986-03), NIH | PD GWAS Consortium (1R01CA141668-01), NIH | Collaborative GWAS of Dem... (1R01AG033193-01), NIH | Parkinson Disease Collabo... (2R01NS037167-06), NIH | Drosophila Transgenic RNA... (5R01GM084947-08), NIH | Baylor College of Medicin... (3P30CA125123-09S3), NIH | Exploring the Genetics of... (1K08AG034290-01),...

    Background: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility va...

  • publication . Article . 2012
    Open Access English
    Project: WT | Statistical methods for u... (097364), WT | Understanding the genetic... (090532), RCUK | Assessment of biomedical ... (G0000934), WT | WTCCC2 core activities (085475), WT | Identification and functi... (075491), WT | A national DNA control se... (068545), WT | Resource for psychoses ge... (072894)

    Barrett’s Esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia. Barrett’s Esophagus strongly predisposes to esophageal adenocarcinoma (EAC), a tumour with a very poor prognosis. We have undertake...

  • publication . Other literature type . Article . Conference object . 2018
    Open Access
    Authors:
    James J. Gilchrist; Anna Rautanen; Benjamin P. Fairfax; Tara C. Mills; Vivek Naranbhai; Holly Trochet; Matti Pirinen; Esther Muthumbi; Salim Mwarumba; Patricia Njuguna; ...
    Publisher: Springer Science and Business Media LLC
    Project: WT | Malawi-Liverpool-Wellcome... (074124), WT | Genome-wide association s... (084716), WT | The health consequences o... (091758), WT | Understanding the genetic... (090532), WT | WTCCC2 core activities (085475), EC | IMMUNOGENE (294557), WT | Statistical methods for u... (097364), WT | Genetic susceptibility to... (102342), RCUK | Oxford Regional High-Thro... (G0900747), WT | Mechanisms underlying the... (067902),...

    Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) an...

  • publication . Article . 2017
    Open Access English
    Authors:
    Sud, Amit; Thomsen, Hauke; Law, Philip J; Försti, Asta; Filho, Miguel Inacio da Silva; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg; Wright, Lauren; ...
    Project: NIH | Imputation-based approach... (7U01CA188392-03), EC | COGS (223175), WT | A national DNA control se... (068545), NIH | Elucidating Loci Involved... (5U19CA148537-02), WT | Understanding the genetic... (090532), WT | WTCCC2 core activities (085475), WT | The genetics of weight, B... (076113), RCUK | Health of vegetarians (MR/M012190/1)

    Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totallin...

  • publication . Article . 2013
    Open Access English
    Authors:
    Inez Myin-Germeys; Andreas Meyer-Lindenberg; Markus M Nöthen; Henrik Walter; James Walters; Manuel Mattheisen; Sven Cichon; Richard Bruggeman; Aiden Corvin; Michael Wagner;
    Publisher: Nature Publishing Group
    Project: EC | CRESTAR (279227), EC | ADAMS (242257), WT | Understanding the genetic... (090532), WT | Identification and functi... (075491), WT | WTCCC2 core activities (085475), WT | A national DNA control se... (068545), RCUK | Assessment of biomedical ... (G0000934), WT | Resource for psychoses ge... (072894)

    Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested to contribute to the risk of developing SCZ. Al...

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