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46 research outcomes, page 1 of 5
  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Jianjun Liu;
    Publisher: Nature Research
    Project: NIH | A Haplotype Map for Multi... (5R01NS049477-05), EC | HYPERGENES (201550), NIH | Exploring the consequence... (1R01NS067305-01), NIH | DETERMINANTS OF MS WITHIN... (5R01NS019142-04), NIH | Genetic and non-genetic r... (5R01NS049510-05), RCUK | Fine mapping the results ... (G0700061), WT | A national DNA control se... (068545), RCUK | Assessment of biomedical ... (G0000934), NIH | The Identification of Ris... (1R01AI076544-01), WT | Identification and functi... (075491),...

    Multiple sclerosis (OMIM 126200) is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability.1...

  • publication . Article . 2012
    Open Access
    Authors:
    Dominic Kwiatkowski; Taane Clark; Paul Milligan;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Genomic analysis of malar... (G0600230), WT | Identification and functi... (075491), WT | Understanding the genetic... (090532), WT | Resource centre for genom... (090770)

    BACKGROUND: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signat...

  • publication . Article . 2014
    Open Access English
    Authors:
    Axford, D; Ji, X; Stuart, DI; Sutton, G;
    Publisher: International Union of Crystallography
    Project: RCUK | Structural Studies on Vir... (G1000099), WT | Identification and functi... (075491)

    This work demonstrates that with the use of a microfocus synchrotron beam the structure of a novel viral polyhedrin could be successfully determined from microcrystals within cells, removing the preparatory step of sample isolation and maintaining a favourable biologica...

  • publication . Other literature type . Article . 2013
    Open Access
    Authors:
    Anthony P Monaco; Silvia Paracchini; Beate St Pourcain; Caleb Webber; Nicholas Timpson; George Davey Smith; John P. Kemp; David Evans; Simon Fisher;
    Publisher: Public Library of Science (PLoS)
    Project: WT | Identification and functi... (075491), WT | The Avon Longitudinal Stu... (092731), EC | GENCODYS (241995), WT | Understanding the genetic... (090532), RCUK | Oxford Regional High-Thro... (G0900747)

    Author Summary Humans have developed a population level bias towards right-handedness for tool-use. Understanding the genetic basis of handedness can help explain why this bias exists and may offer clues into the evolution of handedness and brain asymmetry. We have test...

  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Dimitar Angelov; Irina Udalova; Stefan Dimitrov; Peter Humburg;
    Publisher: HAL CCSD
    Project: RCUK | SYSTEMATIC QUANTITATIVE A... (G0700818), WT | Identification and functi... (075491), EC | MODEL-IN (222008), EC | INTEGER (214902)

    Background Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays and other platforms that can map these sites w...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Olivo Miotto; Julian C. Rayner; Alfred Amambua-Ngwa; Alistair Miles; Gil McVean; Samuel O. Oyola; Xinzhuan Su; Francois Nosten; Dushyanth Jyothi; Chris Newbold; ...
    Project: RCUK | Host determinants of mala... (G19/9), WT | Understanding the genetic... (090532), WT | Cancer Genome Project. (077012), RCUK | MRC Centre for Genomics a... (G0600718), WT | Wellcome Trust Sanger Ins... (098051), WT | Resource centre for genom... (090770), WT | Identification and functi... (075491), WT | Record used for WTSI Open... (082370), RCUK | Genomic analysis of malar... (G0600230)

    We describe an analysis of genome variation in 825 Plasmodium falciparum samples from Asia and Africa that reveals an unusual pattern of parasite population structure at the epicentre of artemisinin resistance in western Cambodia. Within this relatively small geographic...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Mahamadou A Thera; Katja Kivinen; Gavin Band; Sophie Uyoga; Ellen Leffler; Daniel Mead; Valentina D Mangano; Charles Newton; Lee Hart; Dominic Kwiatkowski; ...
    Publisher: Nature Publishing Group
    Project: WT | Resource centre for genom... (090770), WT | The health consequences o... (091758), WT | Wellcome Trust Sanger Ins... (098051), WT | Cancer Genome Project. (077012), WT | Learning from the human g... (077383), NIH | Malaria clinical research... (N01AI085346-007), EC | EVIMALAR (242095), WT | Statistical methods for u... (097364), WT | Understanding the genetic... (090532), NIH | Malaria Research Training... (3D43TW001589-07S1),...

    <b>Malaria Genomic Epidemiology Network</b><p> The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major force for human evolutionary selection, but surprisingly few other polymorphisms have been proven to confer resistance to malaria in la...

  • publication . Article . 2011
    Open Access
    Authors:
    Chris C Holmes; McCarthy MI; Juris Viksna; Jia Li; Elaine Holmes; Ugis Sarkans; Jeremy Nicholson; John Lindon; Krina Zondervan; Maria Krestyaninova;
    Publisher: EMBO
    Project: WT | Identification and functi... (075491), RCUK | Robust statistical method... (G0802460), WT | Genetic and Molecular Epi... (085235)

    1 H Nuclear Magnetic Resonance spectroscopy (1 H NMR) is increasingly used to measure metabolite concentrations in sets of biological samples for top-down systems biology and molecular epidemiology. For such purposes, knowledge of the sources of human variation in metab...

  • publication . Article . 2014
    Open Access English
    Authors:
    Davis, O.S.P.; Band, G.; Pirinen, M.; Haworth, C.M.A.; Meaburn, E.L.; Kovas, Yulia; et, al.;
    Publisher: Nature Publishing Group
    Project: AKA | Computationally efficient... (257654), EC | GHCA (295366), WT | A national DNA control se... (068545), WT | Identification and functi... (075491), WT | Statistical methods for u... (097364), WT | Understanding the genetic... (090532), WT | WTCCC2 core activities (085475), WT | Identifying patterns of g... (088984), RCUK | Origins of learning diffi... (G0901245)

    Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children’s ability in reading and mathematics, and...

  • publication . Article . 2015
    Open Access
    Authors:
    Chrissy h. Roberts; Olaimatu Sadia Mahdi; Martin Holland; Sarah Burr; Dominic Kwiatkowski; Mark D Preston; Ines Barroso; Felicity Payne; Matthew Burton; Taane Clark;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Geographic genetic profil... (MR/M01360X/1), WT | Institutional Strategic S... (105609), RCUK | MRC Centre for Genomics a... (G0600718), WT | Cancer Genome Project. (077012), WT | The immunological determi... (079246), WT | Wellcome Trust Sanger Ins... (098051), RCUK | The interactions between ... (MR/K000551/1), WT | The immunological determi... (093368), WT | Identification and functi... (075491), WT | Understanding the genetic... (090532)

    Chlamydia trachomatis causes both trachoma and sexually transmitted infections. These diseases have similar pathology and potentially similar genetic predisposing factors. We aimed to identify polymorphisms and pathways associated with pathological sequelae of ocular Ch...

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