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55 research outcomes, page 1 of 6
  • publication . Conference object . Article . Other literature type . 2017
    Open Access
    Authors:
    Eleanor Wigmore; Jude Gibson; Blair H. Smith; Alison D. Murray; Tom Russ; David Howard; Ian J Deary; Toni-Kim Clarke; Andrew M McIntosh;
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1), WT | Stratifying Resilience an... (104036)

    Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this re...

  • publication . Article . Conference object . 2017
    Open Access English
    Authors:
    Carmen Amador; Blair H. Smith; Caroline Hayward; Reka Nagy; Archie Campbell; Pau Navarro;
    Publisher: Nature Publishing Group
    Project: WT | Stratifying Resilience an... (104036), RCUK | Quantitative trait locus ... (MC_PC_U127561128), RCUK | The Genetics of Complex a... (MC_PC_U127592696)

    Health-related traits are known to vary geographically. Here, Amador and colleagues show that regional variation of obesity-related traits in a Scottish population is influenced more by lifestyle differences than it is by genetic differences.

  • publication . Article . 2018
    Open Access English
    Authors:
    Markus W. Löffler; Pavel Vodička; Michael Hoffmeister; Malcolm Dunlop; Hermann Brenner;
    Publisher: Public Library of Science
    Project: WT | Stratifying Resilience an... (104036), RCUK | Centre for Cognitive Agei... (MR/K026992/1), NIH | Molecular pathological ep... (2U01CA137088-05), RCUK | A genome-wide association... (BB/F019394/1)

    Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Javier de la Fuente; Gail Davies; Andrew D. Grotzinger; Elliot M. Tucker-Drob; Ian J. Deary;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Brain imaging and cogniti... (MR/R024065/1), WT | Stratifying Resilience an... (104036), NIH | Evaluating Longitudinal C... (1R01AG054628-01A1), NIH | Population Research Cente... (5R24HD042849-02)

    <jats:title>Abstract</jats:title><jats:p>It has been known for 125 years that, in humans, diverse cognitive traits are positively intercorrelated; this forms the basis for the general factor of intelligence (<jats:italic>g</jats:italic>). We directly test for a genetic ...

  • publication . Article . Other literature type . Conference object . 2018
    Open Access English
    Authors:
    Heather Whalley; David Howard; Stephen Lawrie; Mark Bastin; Ian J Deary; Simon R. Cox; Xueyi Shen; Andrew M McIntosh; Mark James Adams;
    Publisher: Elsevier, Inc
    Project: WT | Stratifying Resilience an... (104036), RCUK | Brain imaging and cogniti... (MR/M013111/1), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    <p>BACKGROUND: Cognitive ability is an important predictor of lifelong physical and mental well-being, and impairments are associated with many psychiatric disorders. Higher cognitive ability is also associated with greater educational attainment and increased household...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Andrew M McIntosh; Ian J Deary;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1), WT | Stratifying Resilience an... (104036)

    <p>PURPOSE: Psychological resilience, the ability to manage and quickly recover from stress and trauma, is associated with a range of health and wellbeing outcomes. Resilience is known to relate to personality, self-esteem and positive affect, and may also depend upon c...

  • publication . Article . Other literature type . Preprint . 2020
    Open Access English
    Authors:
    Wierenga, Lara M; Doucet, Gaelle E; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N; Albajes-Eizagirre, Anton; Alnaes, Dag; Alpert, Kathryn I; Andreassen, Ole A; ...
    Project: NIH | FUNCTION BIRN (5U24RR021992-04), NIH | Older Breast Cancer Patie... (5R01CA129769-09), NIH | Research and Mentoring on... (4K24MH094614-05), NIH | Multi-group semi-blind IC... (1R01EB000840-01), NIH | Deconstructing Psychoses ... (5R01MH104284-04), WT | Stratifying Resilience an... (104036), NIH | Unified multivariate data... (3R01EB020407-02S1), EC | CoMorMent (847776), NIH | Quantitative Behavioral a... (4R01MH101111-04), NIH | Genetic markers of white ... (5RC1MH089257-02),...

    <jats:title>Abstract</jats:title><jats:p>For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortiu...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Andrew M McIntosh; Ian J Deary;
    Publisher: Elsevier
    Project: WT | Stratifying Resilience an... (104036), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Background<br/><br/>General cognitive function predicts psychiatric illness across the life course. This study examines the role of pleiotropy in explaining the link between cognitive function and psychiatric disorder.<br/><br/>Methods<br/><br/>We use two large genome-w...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Robert Hillary; Tara Spires-Jones; Andrew M McIntosh; Anna Stevenson;
    Publisher: Nature Publishing Group UK
    Project: WT | Stratifying Resilience an... (104036), RCUK | Centre for Cognitive Agei... (MR/K026992/1), WT

    Abstract The identification of biomarkers that discriminate individual ageing trajectories is a principal target of ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks ...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Harris, Mathew A.; Shen, Xueyi; Cox, Simon R.; Gibson, Jude; Adams, Mark J.; Clarke, Toni-Kim; Deary, Ian J.; Lawrie, Stephen M.; McIntosh, Andrew M.; Whalley, Heather C.;
    Project: RCUK | Brain imaging and cogniti... (MR/M013111/1), RCUK | Brain imaging and cogniti... (MR/R024065/1), NIH | Evaluating Longitudinal C... (1R01AG054628-01A1), WT | Stratifying Resilience an... (104036)

    <jats:title>Abstract</jats:title><jats:sec id="S003329171900165X_sec_a1" sec-type="other"><jats:title>Background</jats:title><jats:p>Substantial clinical heterogeneity of major depressive disorder (MDD) suggests it may group together individuals with diverse aetiologies...

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