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74 research outcomes, page 1 of 8
  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Vilmundur Gudnason; Ashish Kumar; Bonnie Joubert; Josee Dupuis; Daan Loth; Martin Tobin; Bernd Meibohm; Lies Lahousse; David Couper; Alanna Morrison; ...
    Publisher: Columbia University
    Project: NIH | Genetic Determinants of V... (5R01AG032098-03), NIH | THE FRAMINGHAM HEART STUD... (N01HC025195-005), NIH | CHARGE consortium: gene d... (2R01HL105756-07), WT | Genetics and genomics of ... (086596), NIH | CORONARY HEART DISEASE &S... (N01HC085081-016), NIH | DYNAMICS OF HEALTH .AGING... (N01AG062101-015), SNSF | Aromatase and Breast Canc... (3233-054996), NIH | PATHOLOGY MONITORING OF N... (N01AG002103-000), NIH | Genome-Wide Association f... (5R01HL087641-02), SNSF | Gene-environment interact... (PDFMP3-123171),...

    <p>BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.</p><p>METHODS: We performed GWAS of the rate of change in force...

  • publication . Article . Other literature type . Conference object . 2017
    Open Access English
    Authors:
    Thomas Foltynie; Eduardo De Pablo-Fernández; Patrick Lewis; George Davey Smith; Neil Pearce; Alastair Noyce; Debbie Lawlor; Nicholas Wood; Gibran Hemani;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Discovery of Rare Variant... (1P50NS071674-01), NIH | Parkinson Disease Collabo... (2R01NS037167-06), NIH | PD GWAS Consortium (1R01CA141668-01), NIH | Prospective studies on Pa... (1Z01ES101986-03), RCUK | Determining the genetic a... (G1100643), RCUK | Dissecting the role of LR... (MR/L010933/1), EC | MARKMD (230596), RCUK | Genome wide analysis of Y... (G0700943), WT | WTCCC3 core activities. (090355), RCUK | Understanding the genes f... (MR/N026004/1),...

    Background Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse...

  • publication . Article . Other literature type . Conference object . 2014
    Open Access English
    Authors:
    Holmes, Michael V; Dale, Caroline E; Zuccolo, Luisa; Silverwood, Richard J; Guo, Yiran; Ye, Zheng; Prieto-Merino, David; Dehghan, Abbas; Trompet, Stella; Wong, Andrew; ...
    Project: NIH | CORONARY HEART DISEASE &S... (N01HC085080-018), NIH | CORONARY HEART DISEASE &S... (N01HC085081-016), NIH | Genome-Wide Association f... (5R01HL087641-02), WT | The Avon Longitudinal Stu... (092731), NHMRC | Maintaining and developin... (403963), RCUK | Vitamin D and health: gen... (G0601653), NIH | STUDY CORONARY HEART DISE... (N01HC048049-020), NIH | CORONARY HEART DISEASE AN... (N01HC085082-024), NHMRC | Predicting health and dis... (634492), NIH | CORONARY HEART DISEASE RI... (N01HC048050-038),...

    Lista completa dos Autores: Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borin...

  • publication . Article . Conference object . 2015
    Open Access
    Authors:
    Nicholas Timpson; George Davey Smith;
    Publisher: Oxford University Press (OUP)
    Project: WT | The 1958 Birth Cohort Bio... (095219), RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | The 1958 Birth Cohort Bio... (G1001799), WT , WT | The Avon Longitudinal Stu... (102215), RCUK | Causal analyses, statisti... (MC_UU_12013/3), WT | The genetics of weight, B... (076113)

    Whooping cough is currently seeing resurgence in countries despite high vaccine coverage. There is considerable variation in subject-specific response to infection and vaccine efficacy, but little is known about the role of human genetics. We carried out a case–control ...

  • publication . Preprint . Article . 2016
    Open Access English
    Authors:
    Pardiñas, Antonio F; Holmans, Peter; Pocklington, Andrew J; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | CRESTAR (279227), NHMRC | Genome-wide association s... (552498), NHMRC | Genetics of melanoma risk... (389875), NHMRC | Statistical Methods and A... (389892), RCUK | Molecular Genetics of Sch... (G0800509), NHMRC | Research Fellowship - Gra... (442915), NHMRC | Association Screen of Hig... (442981), WT | 10,000 UK genome sequence... (091310), NHMRC | Novel statistical genetic... (496675), NHMRC | Genetics of melanoma risk... (241944),...

    <jats:p>Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-sc...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Charlie Lees; Nadira Yuldasheva; Panos Deloukas; Mark Iles; Alexandra Zhernakova; Melanie Newport; Luis Rodriguez-Rodriguez; Michael C O'Donovan; Eleftheria Zeggini; Padyukov; ...
    Project: NIH | Genes and Phenotype (GAP)... (5RC2AR059092-02), WT | Diabetes and Inflammation... (091157), RCUK | Assessment of biomedical ... (G0000934), NIH | Mapping Autoimmune Phenot... (3R01AI068759-03S1), WT | The genetics of weight, B... (076113), NIH | Bioinformatics and Popula... (1K08AR055688-01A1), NIH | Fine-mapping the MHC asso... (1R01AR062886-01)

    Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European ancestry and 15,870 controls for 129,464 ma...

  • publication . Article . 2017
    Open Access English
    Authors:
    Sud, Amit; Thomsen, Hauke; Law, Philip J; Försti, Asta; Filho, Miguel Inacio da Silva; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg; Wright, Lauren; ...
    Project: NIH | Imputation-based approach... (7U01CA188392-03), EC | COGS (223175), WT | A national DNA control se... (068545), NIH | Elucidating Loci Involved... (5U19CA148537-02), WT | Understanding the genetic... (090532), WT | WTCCC2 core activities (085475), WT | The genetics of weight, B... (076113), RCUK | Health of vegetarians (MR/M012190/1)

    Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totallin...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Rae Yeung; Victoria Arthur; Lucy Wedderburn; Elaine F Remmers; Leah Kottyan; Michael Ombrello; Joanna E Cobb; Jordi Anton; Xavier Estivill; Ricardo Russo; ...
    Project: NIH | Segmental chromosome shar... (5R01AR060893-02), NIH | Genetics and pathophysiol... (1ZIAAR041198-02), NIH | Core B: Pediatric Rheumat... (5P01AR048929-09), NIH | Genetics and Pathophysiol... (1ZIAHG200370-01), NIH | NIDDK IBD Genetics Consor... (5U01DK062420-12), WT | The genetics of weight, B... (076113), NIH | CORE--PEDIATRIC RHEUMATIC... (1P30AR047363-01), RCUK | Assessment of biomedical ... (G0000934), NIH | Identification of the Ulc... (5R01DK076025-02), NIH | A role for IL-1 in SJIA m... (5R01AR061297-03),...

    OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation. sJIA is disting...

  • publication . Article . 2012
    Open Access English
    Authors:
    Luca Ermini; Michael Weale; Steven Sacks;
    Publisher: Pergamon Press
    Project: WT , RCUK | Complement susceptibility... (G0701325), WT | The genetics of weight, B... (076113)

    It is well established that common genetic variants in CFH, CD46 and the CFHRs are additional risk factors for the development of aHUS. To examine the hypothesis that common variants in other complement genes have a similar effect we genotyped 501 SNPs in 47 complement ...

  • publication . Article . 2013
    Open Access English
    Authors:
    Ganesh, Santhi K.; Tragante, Vinicius; Guo, Wei; Guo, Yiran; Lanktree, Matthew B.; Smith, Erin N.; Johnson, Toby; Castillo, Berta Almoguera; Barnard, John; Baumert, Jens; ...
    Project: NIH | CORONARY HEART DISEASE RI... (N01HC048047-022), NIH | CHS-Transition Phase -268... (N01HC055222-001), NIH | Mayo Clinic Center for Cl... (5UL1TR000135-08), NWO | Does It Run in the Family... (1900117620), NIH | CORONARY HEART DISEASE AN... (N01HC085085-006), NIH | COMMUNITY AND COHORT SURV... (N01HC055015-028), NIH | CCSP - FIELD CENTER AND U... (N01HC055018-017), WT | Statistical and computati... (093078), NIH | Phenotyping--pharmacodyna... (3U01HL069758-02S1), NIH | A Genome-Wide Association... (5R01HL086694-05),...

    Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorph...

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