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64 research outcomes, page 1 of 7
  • publication . Article . 2015
    Open Access
    Authors:
    Pr, Burton; Mj, Murtagh; Andy Boyd; Jb, Williams; Es, Dove; Se, Wallace; Am, Tassé; Little J; Rl, Chisholm; Gaye A; ...
    Project: RCUK | MICA: The Scottish eHealt... (MR/K007017/1), WT | Influences on psychosocia... (086118), EC | BIOSHARE-EU (261433), EC | BBMRI-LPC (313010), WT | The Avon Longitudinal Stu... (102215), CIHR

    Motivation: The data that put the ‘evidence’ into ‘evidence-based medicine’ are central to developments in public health, primary and hospital care. A fundamental challenge is to site such data in repositories that can easily be accessed under appropriate technical and ...

  • publication . Article . Conference object . Other literature type . 2015
    Open Access English
    Authors:
    Mary Herbert; Ian Wilson;
    Publisher: Public Library of Science
    Project: WT | Genetic factors modulatin... (101876), RCUK | MRC Centre for Neuromuscu... (G0601943), WT | ALSPAC: consolidation of ... (076467), WT | The Avon Longitudinal Stu... (102215)

    Author Summary Emerging evidence raises the possibility that human mitochondrial DNA (mtDNA) is not strictly maternally inherited, but it has not been technically possible to test this hypothesis directly. We identified trios with discordant mtDNA haplotypes, parent-off...

  • publication . Article . Other literature type . Conference object . 2019
    Open Access
    Authors:
    Olga Eyre; Evangelia Stergiakouli; Anita Thapar; George Davey Smith;
    Publisher: Wiley
    Project: WT , WT | The Avon Longitudinal Stu... (102215), WT | Chronic irritability in A... (104408), RCUK | Mendelian randomization t... (MC_UU_00011/1)

    Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neu...

  • publication . Article . Preprint . 2017
    Open Access English
    Authors:
    Gabriel Cuellar Partida; Charles A Laurin; David Evans; George Davey Smith; Jian Yang; Gibran Hemani;
    Publisher: Springer US
    Project: NHMRC | Novel ways of utilizing g... (1085130), RCUK | Using Genetics to Identif... (MC_UU_12013/4), ARC | Future Fellowships - Gran... (FT130101709), WT | The Avon Longitudinal Stu... (102215), WT

    We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals’ phased genoty...

  • publication . Article . Conference object . 2017
    Open Access English
    Authors:
    Charlotte A M Cecil; Caroline Relton; Esther Walton; DR. FARID, S.H. M.H. M. Kn.; Barbara Maughan; Tom Gaunt; Edward Barker; Alan J. Meehan; Richard Rowe;
    Project: RCUK | Epigenetic Epidemiology (MC_UU_12013/2), RCUK | How early stress gets und... (ES/N001273/1), NIH | Epigenetic Pathways to Co... (4R01HD068437-03), WT | The Avon Longitudinal Stu... (102215), WT , RCUK | Data mining and bioinform... (MC_UU_12013/8), RCUK | Accessible resource for i... (BB/I025263/1)

    In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and hea...

  • publication . Other literature type . Preprint . 2020
    Open Access
    Authors:
    Joshua A Bell; Diana L Santos Ferreira; Abigail Fraser; Ana Luiza G Soares; Laura D Howe; Deborah A Lawlor; David Carslake; George Davey Smith; Linda M O'Keeffe;
    Publisher: medRxiv
    Project: EC | LIFECYCLE (733206), RCUK | Life course epidemiology ... (MR/M009351/1), EC | ObesityDevelop (669545), RCUK | Mediation analysis in lif... (MR/M020894/1), RCUK | From Mendelian Randomizat... (MC_UU_12013/1), NIH | ACTIVATING LAMININ FOR RE... (5R01EY010324-02), WT | The Avon Longitudinal Stu... (102215)

    <jats:p>Background: Males experience higher rates of coronary heart disease (CHD) than females, but the circulating traits underpinning this difference are poorly understood. We examined sex differences in detailed cardiometabolic traits measured at four life stages, sp...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Lotte Houtepen; Caroline Relton; Rebecca Hardy; Laura Howe; Matthew Suderman; Diana Kuh;
    Project: RCUK | Mediation analysis in lif... (MR/M020894/1), RCUK | Epigenetic Epidemiology (MC_UU_12013/2), WT | The Avon Longitudinal Stu... (102215), NIH | Early life adversity and ... (1R01AG048835-01), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), RCUK | Early life adversity and ... (ES/M010317/1), RCUK | INTERpreting epigenetic s... (ES/N000382/1), WT

    Abstract Childhood adversity affects later health, but the underlying molecular mechanisms are unclear. Although there is some evidence from animal models and case-control studies of a role for DNA methylation, evidence from human population-based studies is limited. In...

  • publication . Article . 2017
    Open Access
    Authors:
    Debbie Lawlor;
    Publisher: Informa UK Limited
    Project: WT | The Avon Longitudinal Stu... (102215), WT , WT | The relationship of the m... (092830), RCUK | The menopausal transition... (G1001357)

    ABSTRACT We investigated the experience and perspectives of menopause among 48 UK mothers through qualitative in-depth interviews. Interviews were analyzed thematically then explored using social science theories. Three interdependent narratives emerged: menopause as a ...

  • publication . Conference object . Article . 2015
    Open Access
    Authors:
    Kate Northstone; Tim Morris; Laura Howe;
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Integrative epidemiology ... (MC_UU_12013/5), RCUK | thLongitudinal modelling ... (G1002375), RCUK | Early life adversity and ... (ES/M010317/1), NIH | Early life adversity and ... (1R01AG048835-01), WT , WT | The Avon Longitudinal Stu... (102215)

    Summary Background A number of studies have found associations between multiple aspects of social adversity and obesity in childhood, yet this research has largely been limited to cross-sectional data. Objectives This study aimed to address this limitation by using life...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Shriberg, Lawrence D.; Wren, Yvonne E.;
    Project: RCUK | The origins, outcomes and... (G0501804), NIH | Developmental Phonologica... (5R01DC000496-17), WT | The Avon Longitudinal Stu... (102215)

    ABSTRACT Recent studies report prevalence, phenotype, and persistence findings for a paediatric motor speech disorder in addition to childhood dysarthria and childhood apraxia of speech termed Speech Motor Delay (SMD). The aim of the present study was to determine if th...

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