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68 research outcomes, page 1 of 7
  • publication . Article . Other literature type . Conference object . 2016
    Open Access English
    Authors:
    Matthew Kearnes; Andrew Balmer;
    Project: EC | ENLIFE (616510), RCUK | Deploying Synthetic Biolo... (EP/H023488/1), RCUK | URSULA: Urban River Corri... (EP/F007388/1), RCUK | An infrastructure for pla... (EP/J02175X/1), RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), RCUK | Standards for the Design ... (BB/F018746/1), ARC | Future Fellowships - Gran... (FT130101302), RCUK | Centre for Synthetic Biol... (EP/G036004/1), RCUK | In vivo integral feedback... (EP/K020781/1), RCUK | SynthSys-Mammalian: Edinb... (BB/M018040/1),...

    In this paper we identify five rules of thumb for interdisciplinary collaboration<br/>across the natural and social sciences. We link these to efforts to move away<br/>from the 'ethical, legal and social issues' (ELSI) framework of interdisciplinarity<br/>and towards a ...

  • publication . Conference object . Article . 2016
    Open Access
    Authors:
    Antonios Lygidakis; Vijaykumar Karuppiah; Robin Hoeven; Aisling Ní Cheallaigh; David Leys; John M. Gardiner; Helen S. Toogood; Nigel S. Scrutton;
    Project: RCUK | Catalysis in motion: acce... (EP/J020192/1), RCUK | Industrial chemicals of t... (BB/J015512/1), RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), RCUK | Innovative Routes to Mono... (BB/M000354/1)

    Abstract Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and (−)‐menthone:(+)‐neomenthol reductase, and the “ene” reductase isopiperitenone reductase. We identified a rare...

  • publication . Article . Other literature type . Conference object . 2016
    Open Access English
    Authors:
    Baudoin Delépine; Pablo Carbonell; Jean-Loup Faulon;
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1)

    Abstract Genetically-encoded biosensors offer a wide range of opportunities to develop advanced synthetic biology applications. Circuits with the ability of detecting and quantifying intracellular amounts of a compound of interest are central to whole-cell biosensors de...

  • publication . Other literature type . Article . 2014
    Open Access
    Authors:
    Douglas Kell;
    Publisher: Royal Society of Chemistry (RSC)
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1)

    The amino acid sequence of a protein affects both its structure and its function. Thus, the ability to modify the sequence, and hence the structure and activity, of individual proteins in a systematic way, opens up many opportunities, both scientifically and (as we focu...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Adam Amara; Eriko Takano; Rainer Breitling;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), EC | TOPCAPI (720793)

    Background Streptomyces species produce a vast diversity of secondary metabolites of clinical and biotechnological importance, in particular antibiotics. Recent developments in metabolic engineering, synthetic and systems biology have opened new opportunities to exploit...

  • publication . Article . Conference object . 2016
    Open Access English
    Authors:
    Colin Levy; Tanja Knaus; Caroline Emilie Paul;
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), RCUK | Catalysis in motion: acce... (EP/J020192/1), EC | BIOMIMIC (327647), EC | BIOSUSAMIN (638271)

    The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Redox biotransformations are potentially attractive, but they rely on<br/>unstable and expensive nicotinamide coenzymes that have prevented their widespread exploitation. S...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Douglas B. Kell; Etheresia Pretorius;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1)

    <jats:title>Abstract</jats:title><jats:p>A well-established development of increasing disease severity leads from sepsis through septic shock, SIRS, multiple organ dysfunction syndrome and cellular and organismal death. We argue that a chief culprit is the LPS-induced a...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Emmanuel Valjent; Philippe Courtet; Amir Pandi; Jean-Loup Faulon; Jerome Bonnet;
    Publisher: Nature Publishing Group
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1), EC | COMPUCELL (637579)

    The range of chemicals detectable by cell-free systems is still limited. Here the authors combine metabolic cascades with transcription factor networks to detect small molecules in complex environments.

  • publication . Preprint . 2019
    Open Access
    Authors:
    Jean-Loup Faulon; Angelo Cardoso Batista;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1)

    <jats:title>Abstract</jats:title><jats:p>Lysate-based cell-free systems have become a major platform to study gene expression but batch-to-batch variation makes protein production difficult to predict. Here we describe an active learning approach to explore a combinator...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Neil Swainston; Mark Dunstan; Adrian J. Jervis; Christopher J. Robinson; Pablo Carbonell; Alan R. Williams; Jean-Loup Faulon; Nigel S. Scrutton; Douglas B. Kell;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | CENTRE FOR SYNTHETIC BIOL... (BB/M017702/1)

    <jats:title>Abstract</jats:title><jats:p>Synthetic biology is typified by developing novel genetic constructs from the assembly of reusable synthetic DNA parts, which contain one or more features such as promoters, ribosome binding sites, coding sequences and terminator...

68 research outcomes, page 1 of 7
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