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60 research outcomes, page 1 of 6
  • publication . Conference object . Other literature type . Article . 2018
    Open Access English
    Authors:
    Neil Davies; Frank Windmeijer; George Davey Smith; Helmut Farbmacher;
    Publisher: Kiel, Hamburg: ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften, Leibniz-Informationszentrum Wirtschaft
    Project: RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Informing educational int... (ES/N000757/1)

    We investigate the behaviour of the Lasso for selecting invalid instruments in linear instrumental variables models for estimating causal effects of exposures on outcomes, as proposed recently by Kang, Zhang, Cai and Small (2016, Journal of the American Statistical Asso...

  • publication . Article . 2017
    Open Access English
    Authors:
    Debbie Lawlor; Laura Howe; Emma L Anderson; Rebecca Hardy;
    Publisher: BMC
    Project: RCUK | Integrative epidemiology ... (MC_UU_12013/5), RCUK | Life course epidemiology ... (MR/M009351/1), NIH | Early life adversity and ... (1R01AG048835-01), RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Mediation analysis in lif... (MR/M020894/1), RCUK | Functional trajectories a... (MC_UU_12019/2), RCUK | Early life adversity and ... (ES/M010317/1), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1)

    Background Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. We aimed to assess associa...

  • publication . Conference object . Article . 2015
    Open Access
    Authors:
    Kate Northstone; Tim Morris; Laura Howe;
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Integrative epidemiology ... (MC_UU_12013/5), RCUK | thLongitudinal modelling ... (G1002375), RCUK | Early life adversity and ... (ES/M010317/1), NIH | Early life adversity and ... (1R01AG048835-01), WT , WT | The Avon Longitudinal Stu... (102215)

    Summary Background A number of studies have found associations between multiple aspects of social adversity and obesity in childhood, yet this research has largely been limited to cross-sectional data. Objectives This study aimed to address this limitation by using life...

  • publication . Article . 2015
    Open Access English
    Authors:
    Fernando C Wehrmeister; Laura Howe; Jeovany Martínez-Mesa;
    Publisher: Springer Nature
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | thLongitudinal modelling ... (G1002375), WT

    Background We investigated whether Body Mass Index (BMI) at 11 years old has a direct effect on bone mass at age 18 operating through alterations to bone growth and development, or whether the association is mediated by concurrent BMI, fat mass (FM), and fat free mass (...

  • publication . Article . 2017
    Open Access English
    Authors:
    George Davey Smith; David Carslake; Finn Rasmussen;
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | From Mendelian Randomizat... (MC_UU_12013/1)

    <p>Aim: To examine whether exposure to increased alcohol availability in utero is associated with later alcohol-related health problems. Method: Register-linked population-based longitudinal study using data from a natural experiment setting, including 363 286 children ...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Neil Davies; Richard Martin; Patrick Kehoe;
    Publisher: BioMed Central
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9)

    <jats:p><jats:bold>Background:</jats:bold> Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Ins...

  • publication . Article . 2016
    Open Access English
    Authors:
    Abigail Fraser; Kate Tilling; Yoav Ben-Shlomo; Laura Howe; Emma L Anderson; Debbie Lawlor; Rachel Cooper; Rebecca Hardy;
    Project: WT | Life course inequalities ... (089979), RCUK | Integrative epidemiology ... (MC_UU_12013/5), RCUK | Life course epidemiology ... (MR/M009351/1), RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Functional trajectories a... (MC_UU_12019/2), NIH | Early life adversity and ... (1R01AG048835-01), RCUK | Life course determinants ... (MC_UU_12019/4), RCUK | The menopausal transition... (G1001357), WT | The relationship of the m... (092830), RCUK | Identification of normal ... (MR/J011932/1),...

    © The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association. Many questions in life course epidemiology involve mediation and/or interaction because of the long latency period between exposures and outcomes. In this...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Julian Higgins; Jamie Kirkham; James Carpenter; Penny Whiting; Jelena Savović; David Henry; Jonathan Sterne; Jeffrey Valentine; I Boutron; Peter Tugwell; ...
    Publisher: BMJ
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), NIH | STATISTICAL METHODS FOR G... (5P01CA134294-02), RCUK | HOD: Assessing risk of bi... (MR/M025209/1)

    Non-randomized studies of the effects of interventions are critical to many areas of health care evaluation, but their results may be biased. It is therefore important to understand and appraise their strengths and weaknesses. We developed ROBINS-I (“Risk Of Bias In Non...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Cathy Williams; George Davey Smith; Edward Mountjoy; Denize Atan; Neil Davies; Jeremy A. Guggenheim;
    Project: RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Informing educational int... (ES/N000757/1), WT , RCUK | Data mining and bioinform... (MC_UU_12013/8)

    <p>OBJECTIVES: To determine whether more years spent in education is a causal risk factor for myopia, or whether myopia is a causal risk factor for more years in education.</p><p>DESIGN: Bidirectional, two sample mendelian randomisation study.</p><p>SETTING: Publically ...

  • publication . Article . Other literature type . Conference object . 2017
    Open Access English
    Authors:
    Julian Higgins; Sean Harrison; Richard Martin; Hayley Jones;
    Publisher: John Wiley and Sons Inc.
    Project: RCUK | Evidence synthesis of dia... (MR/M014533/1), WT | Molecular, genetic and li... (102432), RCUK | Statistics and Econometri... (MC_UU_12013/9), WT

    Meta-analyses combine the results of multiple studies of a common question. Approaches based on effect size estimates from each study are generally regarded as the most informative. However, these methods can only be used if comparable effect sizes can be computed from ...

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