Filters (3 )
Download Results
82 research outcomes, page 1 of 9
  • publication . Conference object . Article . Other literature type . 2018
    Open Access English
    Authors:
    Neil Davies; Frank Windmeijer; George Davey Smith; Helmut Farbmacher;
    Publisher: Kiel, Hamburg: ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften, Leibniz-Informationszentrum Wirtschaft
    Project: RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Informing educational int... (ES/N000757/1)

    We investigate the behaviour of the Lasso for selecting invalid instruments in linear instrumental variables models for estimating causal effects of exposures on outcomes, as proposed recently by Kang, Zhang, Cai and Small (2016, Journal of the American Statistical Asso...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Xiong, Ziyi; Dankova, Gabriela; Howe, Laurence J; Lee, Myoung Keun; Hysi, Pirro G; de Jong, Markus A; Zhu, Gu; Adhikari, Kaustubh; Li, Dan; Li, Yi; ...
    Publisher: eLife Sciences Publications, Ltd
    Project: WT , NIH | 3D Analysis of Normal Fac... (5U01DE020078-04), NWO | NCHA Subsidiebesluit 2008... (2300155116), NHMRC | Advancing our understandi... (1103623), NIH | The Genetic Architecture ... (5R01DE027023-02), EC | VISAGE (740580), NIH | Health outcomes and impro... (1R01DD000295-01), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | The genetics of human phy... (BB/I021213/1), NIH | Extending the Phenotype o... (5R01DE016148-12)

    <jats:title>Abstract</jats:title><jats:p>The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited despite the relevance for various fields of science and application. A series of genome-wide assoc...

  • publication . Article . 2020
    Open Access English
    Authors:
    Monika Frysz; Jennifer Gregory; Richard M. Aspden; Lavinia Paternoster; Jonathan H. Tobias;
    Publisher: Nature Publishing Group UK
    Project: WT , RCUK | Mendelian randomization t... (MC_UU_00011/1), WT | Bristol Molecular, Geneti... (105504)

    Hip shape is an important determinant of hip osteoarthritis (OA), which occurs more commonly in women. However, it remains unclear to what extent differences in OA prevalence are attributed to sex differences in hip shape. Here, we explore sex differences in proximal fe...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Olga Eyre; Evangelia Stergiakouli; Anita Thapar; George Davey Smith;
    Publisher: John Wiley and Sons Inc.
    Project: WT | Chronic irritability in A... (104408), WT | The Avon Longitudinal Stu... (102215), WT , RCUK | Mendelian randomization t... (MC_UU_00011/1)

    Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neu...

  • publication . Preprint . Other literature type . Article . 2019
    Open Access English
    Authors:
    Sean Harrison; Neil Davies; Gibran Hemani;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Informing educational int... (ES/N000757/1), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | Statistical Methods for I... (MC_UU_00011/3)

    <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>BACKGROUND</jats:title><jats:p>The interactive effect of two exposures on an outcome can be confounded. We demonstrate the use of Mendelian Randomization (MR) to estimate unconfounded additive interactions.</jats:p>...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access English
    Authors:
    Walker, Venexia; Davies, Neil; Martin, Richard; Kehoe, Patrick;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Mendelian randomization t... (MC_UU_00011/1)

    ABSTRACT Introduction There is evidence that hypertension in midlife can increase the risk of Alzheimer’s disease and vascular dementia in late life. In addition, some treatments for hypertension have been proposed to have cognitive benefits, independent of their effect...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Caroline Relton; George Davey Smith; Kurt Taylor;
    Project: RCUK | Epigenetic Epidemiology (MC_UU_00011/5), RCUK | Dissecting the molecular ... (MR/S003886/1), RCUK | Mendelian randomization t... (MC_UU_00011/1), WT , RCUK | Data mining epidemiologic... (MC_UU_00011/4)

    Background The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    George Davey Smith; Luke Devey;
    Project: RCUK | Mendelian randomization t... (MC_UU_00011/1), CIHR

    Abstract: Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleuki...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Yousefi, Paul Darius; Richmond, Rebecca; Langdon, Ryan; Ness, Andrew; Liu, Chunyu; Levy, Daniel; Relton, Caroline; Suderman, Matthew; Zuccolo, Luisa;
    Project: RCUK | Accessible resource for i... (BB/I025263/1), RCUK | Mendelian randomization t... (MC_UU_00011/1), RCUK | Epigenetic Epidemiology (MC_UU_00011/5), RCUK | Accessible resource for i... (BB/I025751/1), RCUK | Epigenetics: Environment,... (ES/N000498/1), RCUK | Prenatal alcohol exposure... (G0902144)

    BACKGROUND Recently, an alcohol predictor was developed using DNA methylation at 144 CpG sites (DNAm-Alc) as a biomarker for improved clinical or epidemiologic assessment of alcohol-related ill health. We validate the performance and characterise the drivers of this DNA...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Caroline J Bull; Joshua A Bell; Neil Murphy; Eleanor Sanderson; George Davey Smith; Nicholas J Timpson; Barbara L Banbury; Demetrius Albanes; Sonja I Berndt; Stephane Bezieau; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Data sharing: the Colon C... (3U01CA167551-07S1), NIH | Genome Wide Association C... (5U01HG004446-04), NIH | DIET, HORMONES AND RISK O... (3P01CA087969-03S1), NIH | Core-004 (1P01CA196569-01A1), NHMRC | Risk factors for molecula... (509348), NHMRC | Epidemiology of Chronic D... (209057), NIH | Cancer Epidemiology Cohor... (5UM1CA167552-02), NIH | The Colon Cancer Family R... (5U24CA074794-14), NIH | A Whole Genome Admixture ... (3R01CA063464-09S1), NIH | Understanding Ethnic Diff... (5U01CA164973-04),...

    <jats:p>Importance: Evidence on adiposity altering colorectal cancer (CRC) risk differently among men and women, and on metabolic alterations mediating effects of adiposity on CRC, is unclear. Objective: To examine sex− and site−specific associations of adiposity with C...

82 research outcomes, page 1 of 9
Last index information