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55 research outcomes, page 1 of 6
  • publication . Article . Conference object . 2018
    Open Access English
    Authors:
    Frederik Barkhof;
    Project: RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | Improving the presurgical... (MR/M00841X/1), RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), WT | Image-guided neurosurgica... (106882)

    Abstract T2-FLAIR is the single most sensitive MRI contrast to detect lesions underlying focal epilepsies but 3D sequences used to obtain isotropic high-resolution images are susceptible to motion artefacts. Prospective motion correction (PMC) – demonstrated to improve ...

  • publication . Article . 2019
    Open Access English
    Authors:
    Aksman, Leon M.; Scelsi, Marzia A.; Marquand, Andre F.; Alexander, Daniel C.; Ourselin, Sebastien; Altmann, Andre;
    Publisher: John Wiley & Sons, Inc.
    Project: RCUK | Computational models of n... (EP/J020990/1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | EuroPOND (666992), EC | VPH-DARE@IT (601055), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | MICA: Medical Bioinformat... (MR/L016311/1), CIHR , RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Abstract Longitudinal imaging biomarkers are invaluable for understanding the course of neurodegeneration, promising the ability to track disease progression and to detect disease earlier than cross‐sectional biomarkers. To properly realize their potential, biomarker tr...

  • publication . Other literature type . Article . Conference object . 2017 . Embargo End Date: 07 Mar 2017
    Open Access
    Authors:
    Emil Ljungberg; Patrick Freund; Paul Summers; Ferran Prados Carrasco; M. Jorge Cardoso; Francesco Grussu;
    Publisher: Elsevier
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | CDS-QUAMRI (634541), NIH | In Vivo Macromolecular an... (1R21NS087465-01), EC | I-TEX (288262), NSERC , WT , RCUK | Intelligent Imaging: Moti... (EP/H046410/1), EC | NISCI (681094), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), CIHR

    Highlights • First grey matter spinal cord segmentation challenge. • Six institutions participated in the challenge and compared their methods. • Public available dataset from multiple vendors and sites. • The challenge web site remains open to new submissions.

  • publication . Preprint . 2015
    Open Access English
    Authors:
    Ferraris, Sebastiano; Mendelson, Alex; Ballesio, Gerardo; Vercauteren, Tom;
    Project: EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    This report presents an expression for the number of a multiset's sub-multisets of a given cardinality as a function of the multiplicity of its elements. This is also the number of distinct samples of a given size that may be produced by sampling without replacement fro...

  • publication . Conference object . Article . Other literature type . 2017
    Open Access
    Authors:
    David Thomas; Jonathan Schott; David Cash; Sebastian Crutch; Hui Zhang; Ross William Paterson;
    Project: EC | EuroPOND (666992), RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Anatomy-Driven Brain Conn... (EP/L022680/1), RCUK | Computational PLatform fo... (EP/M006093/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1), RCUK | Seeing what they see: com... (ES/L001810/1)

    Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI) with tract-based spatial statistics to investigate apolipoprotei...

  • publication . Article . Conference object . Other literature type . 2017
    Open Access English
    Authors:
    Gerard R Ridgway; David Cash; Carole Sudre; Ian B Malone; Cassidy Fiford; M. Jorge Cardoso; Josephine Barnes; Jonathan Bartlett;
    Project: EC | VPH-DARE@IT (601055), RCUK | Computational models of n... (EP/J020990/1), RCUK | Detecting, tracking &... (MR/J014257/2), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), WT , RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1), CIHR

    ABSTRACT This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (M...

  • publication . Article . 2016
    Open Access English
    Authors:
    Weston, Philip S.J.; Nicholas, Jennifer M.; Lehmann, Manja; Ryan, Natalie S.; Liang, Yuying; Macpherson, Kirsty; Modat, Marc; Rossor, Martin N.; Schott, Jonathan M.; Ourselin, Sebastien; ...
    Publisher: Lippincott Williams & Wilkins
    Project: RCUK | Magnetic Resonance Imagin... (G116/143), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Diffusion tensor imaging ... (G0900421), RCUK | Defining diseases and tra... (G0801306), RCUK | Detecting, tracking &... (MR/J014257/1), RCUK | Early macrostructural and... (MR/M003108/1), EC | VPH-DARE@IT (601055), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), RCUK | Computational models of n... (EP/J020990/1), WT ,...

    Objective: To identify a cortical signature pattern of cortical thinning in familial Alzheimer disease (FAD) and assess its utility in detecting and tracking presymptomatic neurodegeneration. Methods: We recruited 43 FAD mutation carriers—36 PSEN1, 7 APP (20 symptomatic...

  • publication . Article . Conference object . 2016
    Open Access English
    Authors:
    Jon O. Cleary; Benjamin James Sinclair; Da Ma; Elizabeth Fisher; Nick Powell; Victor Tybulewicz; Holly E Holmes; M. Jorge Cardoso; Frances Wiseman; Mark Lythgoe;
    Publisher: Public Library of Science
    Project: EC | VPH-DARE@IT (601055), RCUK | Computational models of n... (EP/J020990/1), RCUK | UKRMP Safety Hub (MR/K026739/1), RCUK | Using non-invasive in-viv... (NC/K500276/1), WT , RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | Dissection of the cellula... (MR/J013110/1)

    We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying...

  • publication . Article . 2016
    Open Access English
    Authors:
    Andrew Melbourne; Ivor Simpson; Enrico De Vita; David Owen; David Atkinson;
    Publisher: Springer US
    Project: RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Multi-modal, multi-parametric Magnetic Resonance (MR) Imaging is becoming an increasingly sophisticated tool for neuroimaging. The relationships between parameters estimated from different individual MR modalities have the potential to transform our understanding of bra...

  • publication . Preprint . 2018
    Open Access
    Authors:
    Claire Cury; James Rowe; Martina Bocchetta;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | EuroPOND (666992), EC | VPH-DARE@IT (601055), EC | LEASP (678304), WT | Restoring brain function:... (103838), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1)

    <jats:title>Abstract</jats:title><jats:p>Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer’s disease, atrophy can be...

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