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83 research outcomes, page 1 of 9
  • publication . Article . 2014
    Open Access
    Authors:
    Hugh S. C. Martin; Shantenu Jha; Peter V. Coveney;
    Project: RCUK | A new approach to Science... (EP/I017909/1)

    The translocation of nucleotide molecules across biological and synthetic nanopores has attracted attention as a next generation technique for sequencing DNA. Computer simulations have the ability to provide atomistic-level insight into important states and processes, d...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Martin Robinson; Alexandr N. Simonov; Jie Zhang; Alan M. Bond; David Gavaghan;
    Project: ARC | Discovery Projects - Gran... (DP170101535), RCUK | A new approach to Science... (EP/I017909/1)

    Comment: 30 pages, 6 figures

  • publication . Article . Preprint . 2014
    Open Access
    Authors:
    Stephen Chapman; Maria Bruna;
    Publisher: AIP Publishing
    Project: RCUK | A new approach to Science... (EP/I017909/1)

    The quasi-steady-state approximation (or stochastic averaging principle) is a useful tool in the study of multiscale stochastic systems, giving a practical method by which to reduce the number of degrees of freedom in a model. The method is extended here to slow-fast sy...

  • publication . Article . Preprint . 2017
    Open Access English
    Authors:
    Martin Robinson; Maria Bruna;
    Publisher: Elsevier
    Project: RCUK | A new approach to Science... (EP/I017909/1)

    Aboria is a powerful and flexible C++ library for the implementation of particle-based numerical methods. The particles in such methods can represent actual particles (e.g. Molecular Dynamics) or abstract particles used to discretise a continuous function over a domain ...

  • publication . Thesis . 2020
    Open Access English
    Authors:
    Finnegan, Sam Ronan;
    Publisher: UCL (University College London)
    Project: RCUK | LSI Doctoral Training Cen... (EP/F500351/1), RCUK | Genetic basis of female s... (NE/G00563X/1), RCUK | A new approach to Science... (EP/I017909/1)

    Meiotic drive is a type of selfish genetic element that, in heterozygous males, disables or destroys non-carrier sperm in order to bias its own transmission. Meiotic drive genes are predicted to spread rapidly due to this transmission advantage and even, if sex-linked, ...

  • publication . Article . Other literature type . 2014
    Open Access
    Authors:
    Andrew Pomiankowski; Victor Sojo;
    Project: RCUK | LSI Doctoral Training Cen... (EP/F500351/1), RCUK | A new approach to Science... (EP/I017909/1)

    Author Summary The archaea and bacteria are the deepest branches of the tree of life. The two groups are similar in morphology and share some fundamental biochemistry, including the genetic code, but the differences between them are stark, and rank among the great unsol...

  • publication . Article . 2012
    Open Access English
    Authors:
    Andrew Pomiankowski; Alexander J. Stewart;
    Publisher: BioMed Central
    Project: RCUK | LSI Doctoral Training Cen... (EP/F500351/1), RCUK | Genetic basis of female s... (NE/G00563X/1), RCUK | A new approach to Science... (EP/I017909/1)

    <p>Abstract</p> <p>Background</p> <p>Changes in gene regulatory networks drive the evolution of phenotypic diversity both within and between species. Rewiring of transcriptional networks is achieved either by changes to transcription factor binding sites or by changes t...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Shunzhou Wan; Peter Coveney; David W Wright; Agastya P. Bhati;
    Project: EC | CompBioMed (675451), RCUK | A new approach to Science... (EP/I017909/1), RCUK | MICA: Medical Bioinformat... (MR/L016311/1), EC | ComPat (671564)

    The accurate prediction of the binding affinities of ligands to proteins is a major goal in drug discovery and personalized medicine. The time taken to make such predictions is of similar importance to their accuracy, precision, and reliability. In the past few years, a...

  • publication . Conference object . 2014
    Open Access
    Authors:
    Bardenet, R.; Arnaud Doucet; Holmes, C.;
    Project: RCUK | A new approach to Science... (EP/I017909/1)

    International audience; Markov chain Monte Carlo (MCMC) methods are often deemed far too computationally intensive to be of any practical use for large datasets. This paper describes a methodology that aims to scale up the Metropolis-Hastings (MH) algorithm in this cont...

  • publication . Article . 2016
    Open Access English
    Authors:
    Peter V. Coveney; Shunzhou Wan;
    Publisher: ROYAL SOC CHEMISTRY
    Project: EC | VPH-SHARE (269978), RCUK | A new approach to Science... (EP/I017909/1), RCUK | MICA: Medical Bioinformat... (MR/L016311/1), EC | ComPat (671564)

    The purpose of statistical mechanics is to provide a route to the calculation of macroscopic properties of matter from their constituent microscopic components. It is well known that the macrostates emerge as ensemble averages of microstates. However, this is more often...

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