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87 research outcomes, page 1 of 9
  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Hammond CJ; René Höhn; CCW Klaver; Paul Foster; Ruth E. Hogg; Fotis Topouzis; V.J.M. Verhoeven; Anthony P Khawaja; Katie M Williams; Robert Luben; ...
    Project: NWO | NCHA Subsidiebesluit 2008... (2300155116), WT | Genetics of ageing: the g... (081878), RCUK | Diet, lifestyle and biolo... (G1000143), RCUK | Assessment of biomedical ... (G0000934)

    Published version also available at <a href=http://dx.doi.org/10.1016/j.ophtha.2015.03.018>http://dx.doi.org/10.1016/j.ophtha.2015.03.018</a> Purpose: To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an...

  • publication . Preprint . Article . Other literature type . 2015
    Open Access English
    Authors:
    Sylvia Richardson; Hui Guo; Antony Cutler; deborah smyth; Neil Walker; Stephen Sawcer; Nikolas Pontikos; Chris Wallace; Oliver Burren;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | The genetics of weight, B... (076113), WT | Genes and Pathways in Typ... (089989), WT , WT | Cellular Medicine at the ... (100140), WT | A national DNA control se... (068545), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), RCUK | Assessment of biomedical ... (G0000934), EC | NAIMIT (241447), WT | Diabetes and Inflammation... (091157)

    Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD) and multiple association signals. Nonetheless, accurate maps of these variants are needed, both to fully exploit detailed cell sp...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Thomas Meitinger; René Höhn; CCW Klaver; Omar Mahroo; Paul Foster; Hammond CJ; Ruth E. Hogg; Fotis Topouzis; V.J.M. Verhoeven; Anthony P Khawaja; ...
    Publisher: HAL CCSD
    Project: NWO | NCHA Subsidiebesluit 2008... (2300155116), RCUK | Diet, lifestyle and biolo... (G1000143), WT | Genetics of ageing: the g... (081878), RCUK | Assessment of biomedical ... (G0000934)

    To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E3) Consortium were com...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Steve E Humphries; Karin Leander; Ross Laxton; Rebecca Hardy; Barbara Jefferis; Mika Kivimaki; Shu Ye; John Deanfield; Bruna Gigante; Chris Wallace; ...
    Project: RCUK | The MRC British Genetics ... (G9521010), WT | The genetics of weight, B... (076113), NIH | SOCIAL AND OCCUPATIONAL I... (5R01HL036310-09), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), WT | A national DNA control se... (068545), EC | PHASE (223004), RCUK | Assessment of biomedical ... (G0000934), RCUK | Vitamin D and health: gen... (G0601653)

    Aims: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)- associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived ...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Patrick Concannon; Soumya Raychaudhuri;
    Publisher: Public Library of Science
    Project: NIH | Bioinformatics and Popula... (1K08AR055688-01A1), WT | A national DNA control se... (068545), NIH | Fine-mapping the MHC asso... (1R01AR062886-01), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), RCUK | Assessment of biomedical ... (G0000934)

    DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, however, to collect genotyping data in large cohor...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Udo Seedorf; Matthew Traylor; Joanna Pera; Panos Deloukas; Bo Norrving; Matthew A Brown; Julia Slark; John Attia; Caroline Jackson; Lee Murphy; ...
    Project: WT | A genome wide association... (084724), WT | A national DNA control se... (068545), WT | WTCCC2 core activities (085475), RCUK | Assessment of biomedical ... (G0000934)

    Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. ...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Ashish Kumar; Ozren Polasek; Peter Joshi; Panos Deloukas; Ian Sayers; Åsa Johansson; Mika Kähönen; Martin Tobin; Stefan Enroth; Deborah Jarvis; ...
    Publisher: Nature Publishing Group
    Project: AKA | The Cardiovascular Risk i... (121584), RCUK | Centre for Cognitive Agei... (MR/K026992/1), SNSF | Swiss Study on Air Pollut... (3200-042532), NIH | Genetics of cardiovascula... (5R01HL087679-02), AKA | Impact of childhood growt... (134309), SNSF | Swiss Cohort Study on Air... (33CS30_134276), WT | Cambridge Institute for M... (079895), SNSF | Swiss Cohort Study on Air... (33CSC0-108796), SNSF | The SAPALDIA II Cohort St... (3100-059302), SNSF | The SAPALDIA II Cohort St... (3247-065896),...

    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes P...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Mika Kivimaki; Thomas Michael Palmer; Sarah Lewis; Yoav Ben-Shlomo; Avan Aihie Sayer; Rachel Cooper; Ian J Deary; Meena Kumari; Cyrus Cooper; Richard Martin;
    Project: NIH | SOCIAL AND OCCUPATIONAL I... (5R01HL036310-09), NIH | Health behaviors over the... (5R01AG034454-02), WT | The genetics of weight, B... (076113), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), RCUK | Centre for Cognitive Agei... (MR/K026992/1), WT | A national DNA control se... (068545), RCUK | Assessment of biomedical ... (G0000934), NIH | CHANGES IN HEALTH--SOCIOE... (5R01AG013196-03)

    <p>OBJECTIVES: The observed associations between smoking and functional measures at older ages are vulnerable to bias and confounding. Mendelian randomisation (MR) uses genotype as an instrumental variable to estimate unconfounded causal associations. We conducted a met...

  • publication . Article . 2014
    Open Access English
    Authors:
    Faiza Tabassum; Meena Kumari; Ann Rumley; Chris Power; David P. Strachan; Gordon Lowe;
    Publisher: Public Library of Science
    Project: RCUK | Assessment of biomedical ... (G0000934)

    The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cum...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Aroon Hingorani; Vimal Karani; John Whittaker; Elina Hypponen;
    Publisher: Public Library of Science (PLoS)
    Project: WT | The genetics of weight, B... (076113), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), RCUK | Assessment of biomedical ... (G0000934), RCUK | Vitamin D and health: gen... (G0601653)

    Background: Mendelian randomization (MR) studies use genetic variants mimicking the influence of a modifiable exposure to assess and quantify a causal association with an outcome, with an aim to avoid problems with confounding and reverse causality affecting other types...

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