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76 research outcomes, page 1 of 8
  • publication . Preprint . 2020
    Open Access English
    Authors:
    Hiu-Gwen Tsang; Emily L. Clark; Greg R. Markby; Stephen J. Bush; David A. Hume; Brendan M. Corcoran; Vicky E. MacRae; Kim M. Summers;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Future-Proofing the Susta... (MR/K001744/1), RCUK | EASTBIO DTP (BB/J01446X/1), RCUK | Functional Annotation of ... (BB/L001209/1)

    <jats:title>Abstract</jats:title><jats:p>Large animal models are of increasing importance in cardiovascular disease research as they demonstrate more similar cardiovascular features (in terms of anatomy, physiology and size) to humans than do rodent species. The mainten...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Michael MacDonald; Cornelis Weijer;
    Publisher: Springer Science and Business Media LLC
    Project: WT | A systems approach to che... (094131), RCUK | Cellular mechanisms of ga... (BB/K00204X/1), RCUK | Construction of a novel D... (BB/G015082/1), RCUK | Transgenic reporters for ... (BB/E011276/1), RCUK | Future-Proofing the Susta... (MR/K001744/1)

    Primitive streak formation in the chick embryo involves large scale highly coordinated flows of over 100.000 cells in the epiblast. These large scale tissue flows and deformations can be correlated with specific anisotropic cell behaviours in the forming mesendoderm thr...

  • publication . Article . Preprint . Conference object . Other literature type . 2019
    Open Access English
    Authors:
    Diego Robledo; Alejandro P. Gutiérrez; Agustín Barría; Jean P. Lhorente; Ross D. Houston; José M. Yáñez; José M. Yáñez;
    Publisher: Frontiers Media S.A.
    Project: RCUK | Future-Proofing the Susta... (MR/K001744/1), RCUK | RCUK-CONICYT: Utilising f... (BB/N024044/1)

    <jats:title>ABSTRACT</jats:title><jats:p>Sea lice (<jats:italic>Caligus rogercresseyi</jats:italic>) are ectoparasitic copepods which have a large negative economic and welfare impact in Atlantic salmon (<jats:italic>Salmo salar</jats:italic>) aquaculture, particularly ...

  • publication . Article . Conference object . Preprint . Other literature type . 2017
    Open Access
    Authors:
    EL Clark; SJ Bush; MEB McCulloch; IL Farquhar; R Young; L Lefevre; C Pridans; HG Tsang; C Wu; C Afrasiabi; ...
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Transcriptomes, networks ... (BBS/E/D/20211552), RCUK | Functional Annotation of ... (BB/L001209/1), NIH | BioGPS:A crowdsourced por... (4R01GM083924-09), RCUK | Future-Proofing the Susta... (MR/K001744/1), RCUK | National Capability Grant... (BBS/E/D/20310000), RCUK | Farm animal genomics (BBS/E/D/20211550)

    Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across multiple tissues has aided genome annotation and supported functional annotation of mammalian genes. We present a...

  • publication . Preprint . 2015
    Open Access English
    Authors:
    Mark Blaxter; Georgios Koutsovoulos;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | National Capability Grant... (BBS/E/D/20310000), RCUK | Future-Proofing the Susta... (MR/K001744/1)

    <jats:p>Background Second and third generation sequencing technologies have revolutionised bacterial genomics. Short-read Illumina reads result in cheap but fragmented assemblies, whereas longer reads are more expensive but result in more complete genomes. The Oxford Na...

  • publication . Article . 2017
    Open Access English
    Authors:
    Margaret Dellett; Stephen Bridgett; David Simpson;
    Publisher: Nature Publishing Group UK
    Project: RCUK | Future-Proofing the Susta... (MR/K001744/1)

    <p>Vascular endothelial growth factor (VEGFA), a pivotal regulator of angiogenesis and valuable therapeutic target, is characterised by alternative splicing which generates three principal isoforms, VEGFA121, VEGFA165 and VEGFA189. A second set of anti-angiogenic isofor...

  • publication . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Antonella Fidanza; Nicola Romanò; Prakash Ramachandran; Sara Tamagno; Martha Lopez-Yrigoyen; Alice Helen Taylor; Jennifer Easterbrook; Beth Henderson; Richard Axton; Neil Cowan Henderson; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | A combinatorial approach ... (102853), RCUK | Future-Proofing the Susta... (MR/K001744/1)

    <jats:title>Abstract</jats:title><jats:p>During embryogenesis the hematopoietic system develops through distinct waves that generate progenitors with increasing lineage potential, ultimately producing haematopoietic stem cells (HSCs). In vitro differentiation of human p...

  • publication . Conference object . Article . Other literature type . 2018
    Open Access
    Authors:
    Leader, David P.; Krause, Sue A.; Pandit, Aniruddha; Davies, Shireen A.; Dow, Julian A.T.;
    Project: RCUK | FlyAtlas2: a definitive, ... (BB/K019953/1), RCUK | Future-Proofing the Susta... (MR/K001744/1)

    Abstract FlyAtlas 2 (www.flyatlas2.org) is part successor, part complement to the FlyAtlas database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. Although generated in the same lab with...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Clark, Melody S.; Villota Nieva, Leyre; Hoffman, Joseph I.; Davies, Andrew J.; Trivedi, Urmi H.; Turner, Frances; Ashton, Gail V.; Peck, Lloyd S.;
    Project: RCUK | Future-Proofing the Susta... (MR/K001744/1), RCUK | Effects of warming on rec... (NE/J007501/1)

    Marine encrusting communities play vital roles in benthic ecosystems and have major economic implications with regards to biofouling. However, their ability to persist under projected warming scenarios remains poorly understood and is difficult to study under realistic ...

  • publication . Other literature type . Article . Conference object . 2017
    Open Access
    Authors:
    Megan Torvell; Giles Hardingham; Dr. T. Ian Simpson; Alison C Todd; Elena Galea; Jamie McQueen; Roser Masgrau; Owen Dando; Siddharthan Chandran; David J A Wyllie; ...
    Publisher: Springer Science and Business Media LLC
    Project: WT , RCUK | Future-Proofing the Susta... (MR/K001744/1)

    How neurons and neuronal activity regulate astrocyte functions is poorly understood. Hasel et al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interes...

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