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67 research outcomes, page 1 of 7
  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Kirsi Pietiläinen; Jaakko Kaprio; Johan Gunnar Eriksson; McCarthy MI; Leo-Pekka Lyytikäinen; Mika Ala-Korpela; Mika Kähönen; Peter Wurtz; Antti Kangas;
    Project: WT | Wellcome Trust Sanger Ins... (098051), AKA | CoE in Complex Disease Ge... (213506), AKA | Putting Public Health Gen... (129322), AKA | Center of Excellence in C... (129680), WT | Candidate gene variation ... (069224), AKA | Vitamin D and metabolic h... (139900), AKA | Genetic and environmental... (141054), AKA | A study of aging-related ... (126775), AKA | The Cardiovascular Risk i... (121584), NIH | Genetics of cardiovascula... (5R01HL087679-02),...

    Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of ...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Stephen Burgess;
    Publisher: Lippincott Williams & Wilkins
    Project: RCUK | Centre for molecular-base... (G0600705), EC | DEVHEALTH (269874), WT | Causal inference in large... (100114)

    Background: Instrumental variable methods can estimate the causal effect of an exposure on an outcome using observational data. Many instrumental variable methods assume that the exposure–outcome relation is linear, but in practice this assumption is often in doubt, or ...

  • publication . Article . 2011
    Open Access
    Authors:
    Debbie Lawlor; Dylan M Williams;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Centre for molecular-base... (G0600705), WT , RCUK | The public health importa... (G0701603)

    International audience; Background: Evidence suggests that higher levels of vitamin D and calcium are associated with greater lung function and that vitamin D is inversely associated with atopic sensitisation. It is unknown whether the associations of vitamin D and calc...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Peter Jones; Graham Murray; Jouko Miettunen;
    Publisher: Cambridge University Press (CUP)
    Project: AKA | GENETIC REGULATION OF THE... (120315), NIH | Genetic Influences on ADH... (1R01MH063706-01), AKA | Trends and interactions o... (268336), NIH | Genetics of cardiovascula... (5R01HL087679-02), EC | EURHEALTHAGEING (277849), EC | ENGAGE (201413), AKA | Well-being and health: Re... (104781), RCUK | Centre for molecular-base... (G0600705), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), RCUK | Bayesian Discovery of Reg... (G1002319),...

    <jats:title>Abstract</jats:title><jats:sec id="S0924933800192004_abs1" sec-type="other"><jats:title>Background</jats:title><jats:p>Delayed motor development in infancy and family history of psychosis are both associated with increased risk of schizophrenia, but their in...

  • publication . Article . 2011
    Open Access English
    Authors:
    Debbie Lawlor; Jon Heron; Abigail Fraser; Kate Tilling; Scott Nelson;
    Publisher: Public LIbrary of Science
    Project: RCUK | Centre for molecular-base... (G0600705), NIH | Maternal overnutrition an... (5R01DK077659-04), WT | The Avon Longitudinal Stu... (087997)

    <p><b>Background:</b> Isolated gestational proteinuria may be part of the pre-eclampsia disease spectrum. Confirmation of its association with established pre-eclampsia risk factors and higher blood pressure in uncomplicated pregnancies would support this concept.</p>\u...

  • publication . Article . 2011
    Open Access English
    Authors:
    Rachel Freathy; Thomas Michael Palmer; Sarah Lewis; George Davey Smith; Ricardo Araya; Matthew Hickman; Marcus Munafo;
    Publisher: Public Library of Science
    Project: WT | ALSPAC: consolidation of ... (076467), RCUK | Centre for molecular-base... (G0600705)

    Smokers have a higher prevalence of major depressive episodes and depressive symptoms than the general population, but whether this association is causal, or is due to confounding or reverse causation is uncertain because of the problems inherent in some epidemiological...

  • publication . Article . 2013
    Open Access
    Authors:
    Stefan Enroth; Alex Couto Alves; Ashish Kumar; Ozren Polasek; Caroline Hayward; Eva Reischl; Lorna M Lopez; Gian Andri Thun; Michele Zorzetto; Victoria Jackson; ...
    Publisher: Public Library of Science (PLoS)
    Project: SNSF | SAPALDIA COHORT STUDY: Mo... (32473B-104288), NIH | Genetic Influences on ADH... (1R01MH063706-01), SNSF | Swiss Study on Air Pollut... (3200-042532), NIH | Genetics of cardiovascula... (5R01HL087679-02), SNSF | Swiss Cohort Study on Air... (33CS30_134276), WT | Cambridge Institute for M... (079895), SNSF | Swiss Cohort Study on Air... (33CSC0-108796), SNSF | The SAPALDIA II Cohort St... (3100-059302), SNSF | Swiss Study on Air Pollut... (3200-052720), SNSF | The SAPALDIA II Cohort St... (3247-065896),...

    Author Summary Low levels of alpha1-antitrypsin (AAT) in the blood are a well-established risk factor for accelerated loss in lung function and chronic obstructive pulmonary disease. While a few infrequent genetic polymorphisms are known to influence the serum levels of...

  • publication . Article . Preprint . Other literature type . 2016
    Open Access
    Authors:
    Santiago Rodriguez; Tom Richardson; Nicholas Timpson; A. Mesut Erzurumluoglu;
    Publisher: MDPI AG
    Project: RCUK | Mitochondrial DNA copy nu... (MR/K002767/1), RCUK | Centre for molecular-base... (G0600705), WT | The genetics of weight, B... (076113), WT | WTCCC2 core activities (085475)

    <p>Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations...

  • publication . Other literature type . Article . 2009
    Open Access
    Authors:
    Jonathan Sterne; Debbie Lawlor; Per Tynelius; George Davey Smith; Finn Rasmussen;
    Publisher: BMJ
    Project: RCUK | Centre for molecular-base... (G0600705), RCUK | Infering Epidemiological ... (G0601625)

    Objectives To obtain valid estimates of the association between body mass index (BMI) and mortality by using offspring BMI as an instrumental variable for own BMI. Design Cohort study based on record linkage, with 50 years of follow-up for mortality. Associations of off...

  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Kate Tilling; Laura Howe; George Davey Smith; Jennifer Logue; Debbie Lawlor; Andy Ness;
    Publisher: BMJ
    Project: RCUK | Centre for molecular-base... (G0600705), WT , NIH | Maternal overnutrition an... (5R01DK077659-04)

    Objectives To examine the prospective associations between body mass index (BMI), waist circumference, and fat mass in childhood and cardiovascular risk factors at age 15-16.\ud \ud Design Prospective cohort study.\ud \ud Setting Avon Longitudinal Study of Parents and C...

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