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226 research outcomes, page 1 of 23
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Eleanor Wigmore; Jude Gibson; Blair H. Smith; Alison D. Murray; Tom Russ; David Howard; Ian J Deary; Toni-Kim Clarke; Andrew M McIntosh;
    Publisher: Springer Science and Business Media LLC
    Project: WT | Stratifying Resilience an... (104036), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this re...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Futao Zhang; Wenhan Chen; Zhihong Zhu; Qian Zhang; Marta F. Nabais; Ting Qi; Ian J. Deary; Naomi R. Wray; Peter M. Visscher; Allan F. McRae; ...
    Project: WT , NHMRC | Neurogenetics and Statist... (1078037), NHMRC | Using genomics to underst... (1078901), NHMRC | Complex trait genomics (1113400), NHMRC | Genetics of DNA Methylati... (1083656), RCUK | Centre for Cognitive Agei... (MR/K026992/1), NHMRC | Methods and software tool... (1107258)

    <jats:title>Abstract</jats:title><jats:p>The rapid increase of omic data in the past decades has greatly facilitated the investigation of associations between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts. Here, we proposed a mixed-lin...

  • publication . Article . 2018
    Open Access English
    Authors:
    Markus W. Löffler; Pavel Vodička; Michael Hoffmeister; Malcolm Dunlop; Hermann Brenner;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | A genome-wide association... (BB/F019394/1), NIH | Molecular pathological ep... (2U01CA137088-05), WT | Stratifying Resilience an... (104036), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort...

  • publication . Article . 2017
    Open Access English
    Authors:
    Iveson, Matthew H.; Čukić, Iva; Der, Geoff; Batty, G. David; Deary, Ian J.;
    Publisher: Oxford University Press
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Background: Higher early-life intelligence is associated with a reduced risk of mortality in adulthood, though this association is apparently hardly attenuated when accounting for early-life socio-economic status (SES). However, the use of proxy measures of SES means th...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    David Alexander Dickie; Mark Bastin; Ian J Deary; Simon R. Cox; Andrew M McIntosh; Joanna Wardlaw;
    Project: RCUK | Brain white matter imagin... (G0701120), RCUK | Brain imaging and cogniti... (MR/M013111/1), RCUK | Brain white matter imagin... (G1001245), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Regional cortical brain volume is the product of surface area and thickness. These measures exhibit partially distinct trajectories of change across the brain’s cortex in older age, but it is unclear which cortical characteristics at which loci are sensitive to cognitiv...

  • publication . Article . 2017
    Open Access
    Authors:
    David Alexander Dickie; Mark Bastin; Ian J Deary; Joanna Wardlaw;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Brain imaging and cogniti... (MR/M013111/1), WT | Blood brain barrier dysfu... (088134), EC | SVDs-at-target (666881), RCUK | Brain white matter imagin... (G0701120), WT , RCUK | Brain white matter imagin... (G1001245), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Purpose Quantitative assessment of white matter hyperintensities (WMH) on structural Magnetic Resonance Imaging (MRI) is challenging. It is important to harmonise results from different software tools considering not only the volume but also the signal intensity. Here w...

  • publication . Article . Doctoral thesis . 2015
    Open Access English
    Authors:
    Sarah McGrory; John M. Starr; Susan D. Shenkin; Elizabeth J. Austin; John R. Hodges;
    Publisher: S. Karger AG
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    This thesis sought to address the application of non-parametric item response theory (NIRT) to cognitive and functional assessment in dementia. Performance on psychometric tests is key to diagnosis and monitoring of dementia. NIRT can be used to improve the psychometric...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Albert V Smith; Michele Callisaya; Rebekah McWhirter; Claes Ohlsson; David Karasik; Simon Mooijaart; Velandai Srikanth; Marian Beekman; Jessica Faul; Russell Thomson; ...
    Project: NIH | HEALTH ABC--COORDINATING ... (N01AG062106-019), NIH | Institute for Clinical an... (3UL1RR025005-03S2), NIH | SHORT-TERM STABILITY OF C... (1P30AG010161-01), NIH | CHARGE consortium: gene d... (2R01HL105756-07), NIH | Risk Factors, Pathology, ... (5R01AG015819-07), NIH | OSTEOPOROTIC FRACTURES--V... (3R01AR035584-05S1), NIH | CTSA INFRASTRUCTURE FOR C... (2UL1RR024140-06), EC | IDEAL (259679), NIH | Study of Osteoporotic Fra... (2R01AG027576-22A1), NWO | NCHA Subsidiebesluit 2008... (2300155116),...

    Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed i...

  • publication . Article . Other literature type . Preprint . 2017
    Open Access English
    Authors:
    Wang, Yunzhang; Karlsson, Robert; Lampa, Erik; Zhang, Qian; Hedman, Åsa K.; Almgren, Malin; Almqvist, Catarina; McRae, Allan F.; Marioni, Riccardo E.; Ingelsson, Erik; ...
    Publisher: Uppsala universitet, Kardiovaskulär epidemiologi
    Project: NIH | GENETIC AND ENVIRONMENTAL... (5R01AG004563-02), WT , RCUK | Centre for Cognitive Agei... (MR/K026992/1), NIH | GENETIC &ENVIRONMENTAL IN... (5R01AG010175-04), NIH | Cholesterol metabolism pa... (5R01AG028555-02), EC | PROPAG-AGEING (634821)

    <jats:title>Abstract</jats:title><jats:p>Age-related changes in DNA methylation have been observed in many cross-sectional studies, but longitudinal evidence is still very limited. Here, we aimed to characterize longitudinal age-related methylation patterns (Illumina Hu...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Catharine Gale; John Gallacher;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | UK Dementias Platform (MR/L023784/2), RCUK | Centre for Cognitive Agei... (MR/K026992/1)

    Abstract Evidence suggests that lifestyle factors, e.g. physical activity, moderate the manifestation of genetic susceptibility to obesity. The present study uses UK Biobank data to investigate interaction between polygenic scores (PGS) for two obesity indicators, and l...

226 research outcomes, page 1 of 23
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