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66 research outcomes, page 1 of 7
  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Ruth M Williams; Ivan Candido-Ferreira; Emmanouela Repapi; Daria Gavriouchkina; Upeka Senanayake; Jelena Telenius; Stephen Taylor; Jim Hughes; Tatjana Sauka-Spengler;
    Publisher: bioRxiv
    Project: RCUK | Weatherall Institute of M... (G0902418)

    <jats:title>Abstract</jats:title><jats:p>Precise control of developmental processes is encoded in the genome in the form of gene regulatory networks (GRNs). Such multi-factorial systems are difficult to decode in vertebrates owing to their complex gene hierarchies and t...

  • publication . Other literature type . Article . Conference object . 2018
    Open Access
    Authors:
    Marco Fritzsche; Erdinc Sezgin; Falk Schneider; Dominic Waithe;
    Publisher: American Chemical Society (ACS)
    Project: RCUK | MICA: Nanoscopy Oxford (N... (MR/K01577X/1), WT , RCUK | Weatherall Institute of M... (G0902418), WT | Advanced Microscopy for C... (091911)

    Cells rely on versatile diffusion dynamics in their plasma membrane. Quantification of this often heterogeneous diffusion is essential to the understanding of cell regulation and function. Yet such measurements remain a major challenge in cell biology, usually due to lo...

  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Erdinc Sezgin; Mathias P. Clausen; Dominic Waithe;
    Publisher: Oxford University Press (OUP)
    Project: WT | Advanced super-resolution... (104924), RCUK | MICA: Nanoscopy Oxford (N... (MR/K01577X/1), RCUK | Weatherall Institute of M... (G0902418), WT

    <jats:title>Abstract</jats:title> <jats:p>Motivation: Fluorescence Correlation Spectroscopy (FCS) is a popular tool for measuring molecular mobility and how mobility relates to molecular interaction dynamics and bioactivity in living cells. The FCS technique has been si...

  • publication . Article . Conference object . 2016
    Open Access English
    Authors:
    Emad Moeendarbary; James Felce; Dominic Waithe;
    Project: RCUK | Weatherall Institute of M... (G0902418), RCUK | MICA: Nanoscopy Oxford (N... (MR/K01577X/1), WT

    Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution and accuracy of force reconstruction of the well-established technique of traction force microscopy (TFM) using STED microscopy. The increased spatial resolution of STED-...

  • publication . Article . Preprint . Conference object . Other literature type . 2017
    Open Access
    Authors:
    Daria Gavriouchkina; Ruth M Williams; Martyna Lukoseviciute; Tatiana Hochgreb-Hägele; Upeka Senanayake; Vanessa Chong-Morrison; Supat Thongjuea; Emmanouela Repapi; Adam Mead; Tatjana Sauka-Spengler;
    Project: RCUK | Weatherall Institute of M... (G0902418)

    Highlights • FoxD3 primes neural crest specification by modulating distal enhancers • FoxD3 represses a number of neural crest migration and differentiation genes • In neural crest, FoxD3 acts to switch chromatin from “permissive” to “repressive” • Distinctive gene regu...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access English
    Authors:
    Buono, Mario; Thézénas, Marie-Laëtitia; Ceroni, Alessandro; Fischer, Roman; Nerlov, Claus;
    Publisher: Nature Publishing Group
    Project: RCUK | Weatherall Institute of M... (G0902418)

    c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a role for bidirectional s...

  • publication . Article . Conference object . Other literature type . 2017
    Open Access
    Authors:
    Cecilia Lindskog Bergström; Jingtao Guo; Anne Goriely;
    Project: NIH | Protocol Review and Monit... (3P30CA042014-23S1), NIH | NCRR Confocal Proposal (1S10RR024761-01), WT | Mutations in malformation... (102731), RCUK | Weatherall Institute of M... (G0902418)

    Highlights • Open chromatin in hSSCs correlates with pioneer factors and hormone receptors • hSSC differentiation involves four sequential cellular/developmental states • Key transitions involve the cell cycle, transcription factors, signaling, and metabolism

  • publication . Preprint . 2017
    Open Access
    Authors:
    Chong-Morrison, Vanessa; Sauka-Spengler, Tatjana;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Weatherall Institute of M... (G0902418)

    <jats:title>Abstract</jats:title><jats:p>Circular RNAs are a puzzling class of RNAs with covalently closed loop structure, lacking 5’ and 3’ ends. Present in all cells, no unifying theme has emerged regarding their function. Here, we use transcriptional data obtained by...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Yale Michaels; Thomas Milne; Tudor Fulga; David JHF Knapp;
    Publisher: Nature Publishing Group
    Project: WT | Institutional Strategic S... (105605), RCUK | MULTIPLEX ANALYSIS OF PRI... (BB/N006550/1), RCUK | EPSRC and BBSRC Centre fo... (EP/L016494/1), RCUK | Weatherall Institute of M... (G0902418), RCUK | The Epigenetic Control of... (MC_UU_12009/6), CIHR

    Spatial/temporal control of Cas9 guide RNA expression could considerably expand the utility of CRISPR-based technologies. Current approaches based on tRNA processing offer a promising strategy but suffer from high background. Here, to address this limitation, we present...

  • publication . Preprint . 2017
    Open Access English
    Authors:
    Jill M Brown; Nigel A Roberts; Bryony Graham; Dominic Waithe; Christoffer Lagerholm; Jelena M Telenius; Sara De Ornellas; A Marieke Oudelaar; Izabela Szczerbal; Christian Babbs; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Three-dimensional interro... (MR/N00969X/1), WT | Advanced super-resolution... (104924), RCUK | Weatherall Institute of M... (G0902418), WT | A systematic approach to ... (106130)

    <jats:p>A variety of self-interacting domains, defined at different levels of resolution, have been described in mammalian genomes. These include Chromatin Compartments (A and B)<jats:sup>1</jats:sup>, Topologically Associated Domains (TADs)<jats:sup>2,3</jats:sup>, con...

66 research outcomes, page 1 of 7
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