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114 research outcomes, page 1 of 12
  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Kaitlin H. Wade; David Carslake; Per Tynelius; George Davey Smith; Richard M. Martin;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Causal analyses, statisti... (MC_UU_12013/3), RCUK | Using Genetics to Identif... (MC_UU_12013/4), RCUK | From Mendelian Randomizat... (MC_UU_12013/1), WT , RCUK | Mendelian randomization t... (MC_UU_00011/1), WT | What lies behind the caus... (202802)

    Kaitlin Wade and colleagues investigate associations between BMI and cause-specific mortality in a large cohort of parent-son pairs.

  • publication . Other literature type . Preprint . Article . 2018
    Open Access English
    Authors:
    Marcus Munafo; George Davey Smith;
    Publisher: Oxford University Press
    Project: RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Determinants, Consequence... (MC_UU_12013/6)

    <p>Background: Lower educational attainment is associated with increased rates of smoking, but ascertaining causality is challenging. We used two-sample Mendelian randomization (MR) analyses of summary statistics to examine whether educational attainment is causally rel...

  • publication . Article . 2016
    Open Access
    Authors:
    Luisa Zuccolo; Andrew Wills; George Davey Smith;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Gene-Environment Interact... (5U01NS047537-04), RCUK | Prenatal alcohol exposure... (G0902144), RCUK | From Mendelian Randomizat... (MC_UU_12013/1)

    <jats:title>Abstract</jats:title> <jats:p>Although microcephaly is a feature of Fetal Alcohol Syndrome, it is currently unknown whether low-to-moderate prenatal alcohol exposure affects head circumference. Small magnitude associations reported in observational studies a...

  • publication . Article . Preprint . Other literature type . 2018
    Open Access English
    Authors:
    Debbie Lawlor; Scott Nelson; Mika Ala-Korpela;
    Publisher: BMC
    Project: RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | The menopausal transition... (G1001357), WT | The relationship of the m... (092830), WT , RCUK | Integrative epidemiology ... (MC_UU_12013/5)

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>It remains elusive whether the changes in cardiometabolic biomarkers during the menopausal transition are due to ovarian aging or chronological aging. Well-conducted longitudinal studi...

  • publication . Other literature type . Article . Preprint . 2019
    Open Access
    Authors:
    Morris, Tim T; Davies, Neil M; Smith, George Davey;
    Publisher: bioRxiv
    Project: RCUK | Statistics and Econometri... (MC_UU_12013/9), RCUK | Mendelian randomization t... (MC_UU_00011/1), WT , RCUK | From Mendelian Randomizat... (MC_UU_12013/1), RCUK | Informing educational int... (ES/N000757/1), RCUK | Incorporating genetic dat... (ES/S011021/1)

    The increasing predictive power of polygenic scores for education has led to their promotion by some as a potential tool for genetically informed policy. How accurately polygenic scores predict an individual pupil's educational performance conditional on other phenotypi...

  • publication . Other literature type . Article . 2014 . Embargo End Date: 29 Sep 2018
    Open Access
    Authors:
    Holmes, Michael V; Dale, Caroline E; Zuccolo, Luisa; Silverwood, Richard J; Guo, Yiran; Ye, Zheng; Prieto-Merino, David; Dehghan, Abbas; Trompet, Stella; Wong, Andrew; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), NIH | Epidemiology of Venous Th... (5R01HL059367-10), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), NIH | Institute for Clinical an... (3UL1RR025005-03S2), NHMRC | Role of osteoprotegerin i... (279408), NIH | STUDY CORONARY HEART DISE... (N01HC048048-002), NHMRC | Interaction of Angiotensi... (379600), NWO | NCHA Subsidiebesluit 2008... (2300155116), NIH | CORONARY HEART DISEASE RI... (N01HC048047-022), NIH | CORONARY HEART DISEASE AN... (N01HC085082-024),...

    Lista completa dos Autores: Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borin...

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Evangelia Stergiakouli; Gemma Hammerton; Miriam Cooper; Barbara Maughan; Anita Thapar; George Davey Smith; Lucy Riglin; Søren Dalsgaard; Matthew Hickman;
    Publisher: Wiley
    Project: WT | The Avon Longitudinal Stu... (102215), RCUK | Excessive drinking and al... (MR/L022206/1), RCUK | Identifying the impact of... (MR/M012964/1), RCUK | From Mendelian Randomizat... (MC_UU_12013/1), WT , RCUK | The Centre for Neuropsych... (G0801418), RCUK | Molecular Genetics of Sch... (G0800509), WT | Neurodevelopmental disord... (204895)

    <p>BACKGROUND: Adult ADHD has been assumed to be a continuation of childhood-onset ADHD. However, recent studies have identified individuals with ADHD in adulthood who have not had ADHD in childhood. Whether or not these individuals have a 'typical' neurodevelopmental p...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Bonilla, Carolina; Bertoni, Bernardo; Min, Josine L; Hemani, Gibran; Elliott, Hannah R;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Genome-wide association s... (088806), WT | The causal map of the hum... (208806), RCUK | Epigenetic Epidemiology (MC_UU_00011/5), WT | The Avon Longitudinal Stu... (217065), RCUK | From Mendelian Randomizat... (MC_UU_12013/1)

    Abstract Background Incidence rates for melanoma and non-melanoma skin cancer (NMSC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), have been steadily increasing in all populations. Populations of European ancestry exhibit the highest rate...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access
    Authors:
    Mika Ala-Korpela; Sanna Kuusisto;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | From Mendelian Randomizat... (MC_UU_12013/1)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>HDL-mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have a protective role in atherogenesis. However, the estimation of HDL-CEC is based on in vitr...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Griffith, Gareth; Morris, Tim T; Tudball, Matt; Herbert, Annie; Mancano, Giulia; Pike, Lindsey; Sharp, Gemma C; Palmer, Tom M; Davey Smith, George; Tilling, Kate; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | The causal map of the hum... (208806), RCUK | From Mendelian Randomizat... (MC_UU_12013/1)

    <jats:p>Observational data on COVID-19 including hypothesised risk factors for infection and progression are accruing rapidly, often from non-random sampling such as hospital admissions, targeted testing or voluntary participation. Here, we highlight the challenge of in...

114 research outcomes, page 1 of 12
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