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89 research outcomes, page 1 of 9
  • publication . Article . 2020
    Open Access English
    Authors:
    Peter V. Coveney; Roger R. Highfield;
    Publisher: Elsevier BV
    Project: RCUK | UK Consortium on Mesoscal... (EP/R029598/1), EC | CompBioMed2 (823712), EC | CompBioMed (675451), EC | VECMA (800925), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Abstract Many believe that the future of innovation lies in simulation. However, as computers are becoming ever more powerful, so does the hyperbole used to discuss their potential in modelling across a vast range of domains, from subatomic physics to chemistry, climate...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P.; Karaman, Ibrahim; ...
    Publisher: Nature Research
    Project: RCUK | MRC-PHE Centre for Enviro... (MR/L01341X/1), NIH | COGENT consortium meta-an... (6R21HL121429-03), EC | MOvE-ECG (661395), NIH | Vanderbilt Training Progr... (5T32CA160056-08), NIH | Pharmacogenomics of risk ... (5I01BX003360-02), NIH | Transition of Care in CKD... (5U01DK102163-04), NIH | Search for obesity-associ... (5R01DK107786-02), NIH | Dysmetabolism of Chronic ... (5I01CX000982-03), NIH | Leveraging ancestral dive... (1R01DK101855-01), EC | CVGENES-AT-TARGET (601456),...

    High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We i...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Zito, Antonino; Davies, Matthew N.; Tsai, Pei-Chien; Roberts, Susanna; Andres-Ejarque, Rosa; Nardone, Stefano; Bell, Jordana T.; Wong, Chloe C. Y.; Small, Kerrin S.;
    Publisher: Nature Publishing Group
    Project: RCUK | Epigenetic trajectories o... (ES/N000277/1), WT , RCUK | Genetic and environmental... (MR/R023131/1), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes. Skewed XCI toward one parental X has been observed in several complex human traits, but the extent to which genetics and environment influence skewed XCI is l...

  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    Edward Ferdian; Avan Suinesiaputra; Kenneth Fung; Nay Aung; Elena Lukaschuk; Ahmet Barutcu; Edd Maclean; Jose Paiva; Stefan K. Piechnik; Stefan Neubauer; ...
    Project: NIH | The Cardiac Atlas Project (1R01HL121754-01), RCUK | SmartHeart: Next-generati... (EP/P001009/1), WT | The genetic architecture ... (203553), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Purpose: To demonstrate the feasibility and performance of a fully automated deep learning framework to estimate myocardial strain from short-axis cardiac magnetic resonance tagged images. Methods and Materials: In this retrospective cross-sectional study, 4508 cases fr...

  • publication . Article . 2018
    Open Access English
    Authors:
    Denise Boulanger; Tim Elliott;
    Project: EC | CompBioMed (675451), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Major histocompatibility complex-I (MHC-I) molecules play a central role in the immune response to viruses and cancers. They present peptides on the surface of affected cells, for recognition by cytotoxic T cells. Determining which peptides are presented, and in what pr...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Wright, David W.; Wan, Shunzhou; Meyer, Christophe; van Vlijmen, Herman; Tresadern, Gary; Coveney, Peter V.;
    Project: EC | VECMA (800925), EC | CompBioMed (675451), NSF | More Power to the Many: S... (1713749), RCUK | MICA: Medical Bioinformat... (MR/L016311/1), EC | ComPat (671564)

    Abstract As the application of computational methods in drug discovery pipelines becomes more widespread it is increasingly important to understand how reproducible their results are and how sensitive they are to choices made in simulation setup and analysis. Here we us...

  • publication . Preprint . Article . Other literature type . 2018
    Open Access English
    Authors:
    Joseph Jacob; Brian J. Bartholmai; Coline H.M. van Moorsel; Srinivasan Rajagopalan; Anand Devaraj; Hendrik W. van Es; Teng Moua; Frouke T. van Beek; Ryan Clay; Marcel Veltkamp; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Computer-based analysis o... (209553), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Change in the vessel-related structures, a computer-derived CT variable, is a strong predictor of outcome in idiopathic pulmonary fibrosis and can increase power in future drug trials when used as a co-endpoint alongside forced vital capacity change http://bit.ly/2M7DfK...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Valentina Carapella; Nay Aung; Steffen E Petersen; Filip Zemrak; Mihir M. Sanghvi; Jose Miguel Paiva; Aaron Lee;
    Publisher: Public Library of Science (PLoS)
    Project: WT , RCUK | MICA: Medical Bioinformat... (MR/L016311/1), RCUK | SmartHeart: Next-generati... (EP/P001009/1)

    <h4>Aims</h4> <p>The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovas...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Cherlin, S; Plant, D; Taylor, JC; Colombo, M; Spiliopoulou, A; Tzanis, E; Morgan, AW; Barnes, MW; McKeigue, P; Barrett, J; ...
    Publisher: Wiley
    Project: WT | Development and applicati... (102858), WT , RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Abstract Although a number of treatments are available for rheumatoid arthritis (RA), each of them shows a significant nonresponse rate in patients. Therefore, predicting a priori the likelihood of treatment response would be of great patient benefit. Here, we conducted...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Teresa Rayon; Vicki Metzis; Mina Gouti; kenzo ivanovitch;
    Publisher: Elsevier
    Project: RCUK | Signal integration and in... (BB/J015539/1), WT | The role of 3' UTR variat... (103760), NIH | Neurovascualar Regenerati... (3R01EB016629-03S1), WT | Regulatory dynamics of ve... (098326), RCUK | MICA: Medical Bioinformat... (MR/L016311/1)

    Regional identity precedes neural identity of the anterior and posterior nervous systems.

89 research outcomes, page 1 of 9
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