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66 research outcomes, page 1 of 7
  • publication . Part of book or chapter of book . Other literature type . Preprint . 2017
    Open Access
    Authors:
    Tom Vercauteren; Wenqi Li; Carole Sudre;
    Publisher: Springer International Publishing
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), WT | Image-guided intrauterine... (101957), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Deep-learning has proved in recent years to be a powerful tool for image analysis and is now widely used to segment both 2D and 3D medical images. Deep-learning segmentation frameworks rely not only on the choice of network architecture but also on the choice of loss fu...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Peter Connick; Carolyn Young; Frederik Barkhof; Ferran Prados Carrasco; Siddharthan Chandran; Domenico Plantone;
    Publisher: BMJ Journals
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    <jats:sec><jats:title>Introduction</jats:title><jats:p>The major unmet need in multiple sclerosis (MS) is for neuroprotective therapies that can slow (or ideally stop) the rate of disease progression. The UK MS Society Clinical Trials Network (CTN) was initiated in 2007...

  • publication . Article . Conference object . 2019
    Open Access English
    Authors:
    Jonathan Rohrer; Roberta Ghidoni; SARA PRIONI; Carolina Maruta; Daniela Galimberti; Claire Cury; fabrizio tagliavini; Martin Rossor; sandro sorbi; Martina Bocchetta; ...
    Project: WT | Restoring brain function:... (103838), EC | EuroPOND (666992), EC | LEASP (678304), RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1)

    Highlights • Clustering shape parametrisation allows local shape analysis. • Thalamic shape changes appear 5 years before onset of fronto temporal dementia. • Shape changes seem to occur before volume changes. • Pre-symptomatic shape changes in thalamus are dorsofrontal...

  • publication . Article . Conference object . 2014
    Open Access
    Authors:
    Kris Thielemans; Ninon Burgos; John S Duncan; David Atkinson; Simon Arridge; M. Jorge Cardoso;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    In this work, we further validate a CT and attenuation map (μ-map) synthesis algorithm [1]. The CT synthesis method relies on a pre-acquired set of aligned MRI/CT pairs from multiple subjects. Each MRI from the database is non-rigidly registered to the target MRI. The C...

  • publication . Conference object . Other literature type . Article . 2016
    Open Access
    Authors:
    M. Jorge Cardoso; Claudia A.M. Gandini Wheeler-Kingshott; Ferran Prados Carrasco;
    Project: RCUK | Computational models of n... (EP/J020990/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Multiple sclerosis lesions influence the process of image analysis, leading to tissue segmentation problems and biased morphometric estimates. Existing techniques try to reduce this bias by filling all lesions as normal-appearing white matter on T1-weighted images, cons...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Jason Warren; M. Jorge Cardoso; Silvia Primativo; Jonathan Schott; Ross William Paterson;
    Publisher: (:unav)
    Project: RCUK | Computational PLatform fo... (EP/M006093/1), EC | EuroPOND (666992), NIH | Early Age-of-Onset AD: Cl... (5R01AG045611-05), RCUK | Computational models of n... (EP/J020990/1), RCUK | UK Dementias Platform (MR/L023784/1), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), NIH | DATA MANAGEMENT AND BIOST... (5P50AG023501-03), RCUK | Seeing what they see: com... (ES/L001810/1)

    Abstract Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimer’s disease and recent evidence for genetic risk f...

  • publication . Conference object . Article . Other literature type . 2017
    Open Access
    Authors:
    Andrew Melbourne; David Thomas; Ninon Burgos; Thomas Parker; Christopher Lane; David Cash; Enrico De Vita; John Hardy; Hui Zhang; Sebastian Crutch; ...
    Project: EC | EuroPOND (666992), RCUK | Computational models of n... (EP/J020990/1), RCUK | Medical image computing f... (EP/M020533/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), RCUK | Mental Ageing (MC_UU_12019/3), WT | The consequences of, and ... (200109), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Abstract Background Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade prior to the onset of symptoms. Molecular ...

  • publication . Article . Other literature type . Conference object . 2018
    Open Access
    Authors:
    M. Jorge Cardoso; Carole Sudre;
    Project: WT | Early Life determinants o... (086676), EC | VPH-DARE@IT (601055), WT | Early life factors and bo... (067100), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | Computational models of n... (EP/J020990/1), RCUK | Enhancing the MRC Nationa... (MC_UU_12019/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Background Cardiovascular risk factors vary between ethnicities but little is known about their differential effects on white matter hyperintensities ( WMH ), an indicator of brain aging and burden of cerebrovascular disease. Methods and Results Brain magnetic resonance...

  • publication . Conference object . Article . 2019
    Open Access
    Authors:
    M. Jorge Cardoso; Ian F. Harrison;
    Project: RCUK | Computational models of n... (EP/J020990/1), RCUK | Using non-invasive in-viv... (NC/K500276/1), EC | VPH-DARE@IT (601055), RCUK | UKRMP Safety Hub (MR/K026739/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), CIHR , NIH | PREDICT-ADFTD: Multimodal... (1R01AG055121-01A1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | Dissection of the cellula... (MR/J013110/1)

    Brain volume measurements extracted from structural MRI data sets are a widely accepted neuroimaging biomarker to study mouse models of neurodegeneration. Whether to acquire and analyze data in vivo or ex vivo is a crucial decision during the phase of experimental desig...

  • publication . Article . Conference object . 2019
    Open Access English
    Authors:
    Tom Vercauteren;
    Publisher: Frontiers Media S.A.
    Project: RCUK | Computational models of n... (EP/J020990/1), WT | Wellcome Trust Centre for... (203145), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Objective: This paper presents a systematic review of diffusion MRI (dMRI) and tractography of cranial nerves within the posterior fossa. We assess the effectiveness of the diffusion imaging methods used and examine their clinical applications.<br/><br/>Methods: The Pub...

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