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56 research outcomes, page 1 of 6
  • publication . Article . Conference object . Other literature type . 2015
    Open Access
    Authors:
    Jack Wells; Holly E Holmes; Bernard Siow; Nick Powell; Xavier Golay; Niall Colgan; Mark Lythgoe;
    Publisher: Elsevier BV
    Project: RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), WT , RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | Dissection of the cellula... (MR/J013110/1)

    As the number of people diagnosed with Alzheimer's disease (AD) reaches epidemic proportions, there is an urgent need to develop effective treatment strategies to tackle the social and economic costs of this fatal condition. Dozens of candidate therapeutics are currentl...

  • publication . Conference object . Article . 2014
    Open Access
    Authors:
    John Thornton; John S Duncan; Gavin Winston; Ivana Drobnjak;
    Project: RCUK | Translation of novel imag... (G0802012), RCUK | Computational models of n... (EP/J020990/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Echo Planar Imaging (EPI) is routinely used in diffusion and functional MR imaging due to its rapid acquisition time. However, the long readout period makes it prone to susceptibility artefacts which results in geometric and intensity distortions of the acquired image. ...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Jason Warren; Marzia Scelsi; Martina Bocchetta; Jonathan Rohrer;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Computational models of n... (EP/J020990/1), WT | Profiling dementias using... (091673), RCUK | Developing an evidence ba... (MR/M008525/1), EC | VPH-DARE@IT (601055), RCUK | EPSRC Centre for Doctoral... (EP/L016478/1), EC | BUNGEE-TOOLS (677697), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), WT , RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1)

    Background Semantic variant of primary progressive aphasia (svPPA) is a subtype of frontotemporal dementia characterized by asymmetric temporal atrophy. Methods We investigated the pattern of medial temporal lobe atrophy in 24 svPPA patients compared to 72 controls usin...

  • publication . Article . Conference object . 2016
    Open Access English
    Authors:
    M. Jorge Cardoso; Ivor Simpson; Jonathan Schott; Marco Lorenzi;
    Publisher: Nature Publishing Group
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | VPH-DARE@IT (601055), RCUK | Computational models of n... (EP/J020990/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), CIHR

    The joint analysis of brain atrophy measured with magnetic resonance imaging (MRI) and hypometabolism measured with positron emission tomography with fluorodeoxyglucose (FDG-PET) is of primary importance in developing models of pathological changes in Alzheimer’s diseas...

  • publication . Article . 2017
    Open Access English
    Authors:
    Fiford, Cassidy M; Ridgway, Gerard R; Cash, David M; Modat, Marc; Nicholas, Jennifer; Manning, Emily N; Malone, Ian B; Biessels, Geert Jan; Ourselin, Sebastien; Carmichael, Owen T; ...
    Publisher: Elsevier
    Project: WT | Wellcome Trust Centre for... (203145), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Image-Guided Intrauterine... (NS/A000027/1), RCUK | Detecting, tracking &... (MR/J014257/2), RCUK | Medical image computing f... (EP/M020533/1), EC | VPH-DARE@IT (601055), RCUK | EPSRC UK IMAGE-GUIDED THE... (EP/N027078/1), CIHR , RCUK | The UK GENetic Frontotemp... (MR/M023664/1)

    Age is not only the greatest risk factor for Alzheimer's disease (AD) but also a key modifier of disease presentation and progression. Here, we investigate how longitudinal atrophy patterns vary with age in mild cognitive impairment (MCI) and AD. Data comprised serial l...

  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Zhang, Le; Gooya, Ali; Pereanez, Marco; Dong, Bo; Piechnik, Stefan K.; Neubauer, Stefan; Petersen, Steffen E.; Frangi, Alejandro F.;
    Project: EC | VPH-DARE@IT (601055), RCUK | SmartHeart: Next-generati... (EP/P001009/1)

    Comment: 12 pages, 5 figures, accepted by IEEE Transactions on Biomedical Engineering

  • publication . Other literature type . Article . 2019 . Embargo End Date: 14 Jan 2020
    Open Access
    Authors:
    David Thomas; Jonathan Rohrer; Carolin Heller; Daniela Galimberti; David Cash; Carole Sudre; Martina Bocchetta; sandro sorbi; Alexandre de Mendonça; M. Jorge Cardoso;
    Publisher: Apollo - University of Cambridge Repository
    Project: RCUK | Developing an evidence ba... (MR/M008525/1), EC | VPH-DARE@IT (601055), WT | King's College London Med... (203148), RCUK | Computational models of n... (EP/J020990/1), EC | DEMO (721820), WT | Restoring brain function:... (103838), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), EC | AMYPAD (115952), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), CIHR

    Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative disorders with both sporadic and genetic forms. Mutations in the progranulin gene (GRN) are a common cause of genetic FTD, causing either a behavioural presentation or, less commonly, language i...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Jonathan Rohrer; David Cash;
    Publisher: BioMed Central
    Project: EC | VPH-DARE@IT (601055), RCUK | Computational models of n... (EP/J020990/1), RCUK | Diffusion tensor imaging ... (G0900421), RCUK | Detecting, tracking &... (MR/J014257/1), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    As the need to develop a successful disease-modifying treatment for Alzheimer’s disease (AD) becomes more urgent, imaging is increasingly used in therapeutic trials. We provide an overview of how the different imaging modalities are used in AD studies and the current re...

  • publication . Article . 2016
    Open Access English
    Authors:
    M. Jorge Cardoso; Jonathan Rohrer; Jason Warren; Martina Bocchetta; David Cash;
    Publisher: The Authors. Published by Elsevier Inc.
    Project: RCUK | Computational models of n... (EP/J020990/1), WT | Profiling dementias using... (091673), RCUK | Developing an evidence ba... (MR/M008525/1), EC | VPH-DARE@IT (601055), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1)

    Highlights • Different pattern of cerebellar atrophy in the major genetic forms of FTD • Involvement of the lobule VIIa-Crus I in C9orf72 carriers, related to cognition • MAPT carriers show vermal involvement, linked to emotional processing • GRN carriers show relative ...

  • publication . Article . Other literature type . Conference object . 2018
    Open Access English
    Authors:
    David Thomas; Thomas Parker; Jonathan Schott; Sebastian Crutch; Hui Zhang; Ross William Paterson;
    Publisher: John Wiley and Sons Inc.
    Project: EC | VPH-DARE@IT (601055), EC | EuroPOND (666992), RCUK | Anatomy-Driven Brain Conn... (EP/L022680/1), WT | The consequences of, and ... (200109), RCUK | Computational PLatform fo... (EP/M006093/1), RCUK | Computational models of n... (EP/J020990/1), WT , RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), RCUK | The UK GENetic Frontotemp... (MR/M023664/1),...

    Abstract Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi‐shell diffusion MRI technique that estima...

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