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28 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Obeidat, Ma'en; Hao, Ke; Bossé, Yohan; Nickle, David C; Nie, Yunlong; Postma, Dirkje S; Laviolette, Michel; Sandford, Andrew J; Daley, Denise D; Hogg, James C; ...
    Project: AKA | GENETIC REGULATION OF THE... (120315), AKA | CoE in Complex Disease Ge... (213506), NIH | Genome-Wide Association f... (5R01HL087641-02), NIH | GWA for Gene-Environment ... (5U01HG004402-02), RCUK | Centre for molecular-base... (G0600705), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | A Genome-Wide Association... (5R01HL086694-05), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), NIH | Epidemiology of Venous Th... (5R01HL059367-10), AKA | Well-being and health: Re... (104781),...

    SummaryBackgroundLung function measures reflect the physiological state of the lung, and are essential to the diagnosis of chronic obstructive pulmonary disease (COPD). The SpiroMeta-CHARGE consortium undertook the largest genome-wide association study (GWAS) so far (n=...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Kirsi Pietiläinen; Jaakko Kaprio; Johan Gunnar Eriksson; McCarthy MI; Leo-Pekka Lyytikäinen; Mika Ala-Korpela; Mika Kähönen; Peter Wurtz; Antti Kangas;
    Publisher: Springer Science and Business Media LLC
    Project: AKA | CoE in Complex Disease Ge... (213506), AKA | A study of aging-related ... (126775), AKA | The Cardiovascular Risk i... (121584), AKA | Vitamin D and metabolic h... (139900), WT | Candidate gene variation ... (069224), EC | BIOSHARE-EU (261433), AKA | Dietary, life style, and ... (118081), AKA | MSDs@LIFECOURSE CONSORTIU... (129378), AKA | GENETIC REGULATION OF THE... (120315), AKA | Role of early life risk f... (124282),...

    Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of ...

  • publication . Article . 2013
    Open Access
    Authors:
    Francesco CUCCA; Vilmundur Gudnason; Marika Kaakinen; Philipp Koellinger; Johan Gunnar Eriksson; Roy Thurik; Panos Deloukas; Gonneke Willemsen; Jari Marko Tapani Lahti; David Cesarini; ...
    Project: FWF | MRI white matter abnormal... (P 13180), NWO | BBMRI-NL (2300154272), NIH | Health and Retirement Stu... (3U01AG009740-24S2), NWO | NCHA Subsidiebesluit 2008... (2300155116), RCUK | Centre for molecular-base... (G0600705), AKA | DOHaD-Pubertal growth and... (129287), NIH | NIMH Center for Collabora... (3U24MH068457-07S2), FWF | Genetics of Cerebral Smal... (P 20545), AKA | GENETIC REGULATION OF THE... (120315), NIH | Interstitial Cystitis in ... (1U01DK066134-01),...

    Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, altho...

  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Brian D Hobbs; Claudia Langenberg; Anna Guyatt; Katherine Kentistou; Richard Allen; Ian Sayers; Paul RHJ Timmers; Phuwanat Sakornsakolpat; Ruth Boxall; Louise Wain; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Centre for Cognitive Agei... (MR/K026992/1), SNSF | SAPALDIA COHORT STUDY: Mo... (32473B-104288), AKA | GENETIC REGULATION OF THE... (120315), NIH | Imaging Technician (1P50GM071508-01), RCUK | Centre for molecular-base... (G0600705), MZOS | Determinants of health an... (216-1080315-0302), RCUK | Bayesian Discovery of Reg... (G1002319), NIH | Identifying functional va... (5R01HL137927-02), RCUK | Discovery of genome-wide ... (MR/N011317/1), SNSF | SAPALDIA Off-spring study (PMPDP3_129021),...

    <jats:title>Abstract</jats:title><jats:p>Reduced lung function predicts mortality and is key to the diagnosis of COPD. In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, one-half of which are new. In comb...

  • publication . Article . 2014
    Open Access
    Authors:
    Angelita Pui-Yee Wong; Katri Räikkönen; Martin A Kennedy; Pedro Marques-Vidal; George Davey Smith; Jorgen Engmann; Lavinia Paternoster; Johan Gunnar Eriksson; Anu-Maria Loukola; Tiina Laatikainen; ...
    Project: SNSF | Psychiatric disorders in ... (32003B-105993), AKA | Well-being and health: Re... (104781), EC | ADDICTION (284167), RCUK | Centre for molecular-base... (G0600705), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), NIH | English Longitudinal Stud... (3R01AG017644-14S2), RCUK | Assessment of biomedical ... (G0000934), NWO | Twin-family database for ... (2200125679), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), AKA | CoE in Complex Disease Ge... (213506),...

    <jats:sec><jats:title>Objectives</jats:title><jats:p>To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Mendeli...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Peter Jones; Graham Murray; Jouko Miettunen;
    Publisher: Editions scientifiques Elsevier
    Project: RCUK | Centre for molecular-base... (G0600705), RCUK | Bayesian Discovery of Reg... (G1002319), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), EC | EPI-MIGRANT (279143), AKA | Trends and interactions o... (268336), NIH | Genetics of cardiovascula... (5R01HL087679-02), EC | ENGAGE (201413), AKA | Well-being and health: Re... (104781), EC | EURHEALTHAGEING (277849), NIH | Genetic Influences on ADH... (1R01MH063706-01),...

    <jats:title>Abstract</jats:title><jats:sec id="S0924933800192004_abs1" sec-type="other"><jats:title>Background</jats:title><jats:p>Delayed motor development in infancy and family history of psychosis are both associated with increased risk of schizophrenia, but their in...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Stefan Enroth; Alex Couto Alves; Ashish Kumar; Ozren Polasek; Caroline Hayward; Eva Reischl; Lorna M Lopez; Gian Andri Thun; Michele Zorzetto; Victoria Jackson; ...
    Project: RCUK | Centre for molecular-base... (G0600705), SNSF | The SAPALDIA II Cohort St... (3247-065896), NIH | EARLY INTERVENTION/CHRONI... (N01HR046002-018), WT | A national DNA control se... (068545), EC | ENGAGE (201413), RCUK | Assessment of biomedical ... (G0000934), SNSF | Swiss Study on Air Pollut... (3200-042532), WT | A second-generation genom... (084703), AKA | Well-being and health: Re... (104781), SNSF | SAPALDIA COHORT STUDY: Im... (32473B-104284),...

    Author Summary Low levels of alpha1-antitrypsin (AAT) in the blood are a well-established risk factor for accelerated loss in lung function and chronic obstructive pulmonary disease. While a few infrequent genetic polymorphisms are known to influence the serum levels of...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Rachel Freathy; mads melbye; Holger Prokisch; Elisabeth Thiering; Paul Elliott; Lachlan Coin; Frank Geller;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | JH/CIDR Genotyping for Ge... (5U01HG004438-04), AKA | Developmental origins of ... (129255), AKA | DOHaD-Pubertal growth and... (129287), AKA | Well-being and health: Re... (104781), EC | EMBRYOandLATERHEALTH (648916), RCUK | Centre for molecular-base... (G0600705), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), NIH | Genome Wide Association S... (5R01HD056465-08), AKA | GENETIC REGULATION OF THE... (120315), EC | EURHEALTHAGEING (277849),...

    <jats:title>Abstract</jats:title><jats:p>Early childhood growth patterns are associated with adult metabolic health, but the underlying mechanisms are unclear. We performed genome-wide meta-analyses and follow-up in up to 22,769 European children for six early growth ph...

  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Monique M.B. Breteler;
    Project: NIH | National Cell Repository ... (5U24AG021886-09), NIH | FUNCTION BIRN (5U24RR021992-04), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Structural Brain Abnormal... (1ZIAMH002790-08), RCUK | Mapping the genetic archi... (G0901254), NIH | IN VIVO CORRELATES OF NEU... (3P41RR013642-04S3), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), NWO | Twin-family database for ... (2200125679), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | NIMH Center for Collabora... (3U24MH068457-07S2),...

    Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major d...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Katri Sääksjärvi; Mika Ala-Korpela; Mika Kivimaki; Thomas Wang; Sven van der Lee; Juho Tynkkynen; Sudha Seshadri; Mika Kähönen; Peter Wurtz; Archana Singh-Manoux; ...
    Project: EC | ENGAGE (201413), EC | ADAPTED (115975), AKA | The relation of diet, met... (263836), NWO | BBMRI-NL (2300154272), AKA | The relation of diet, met... (136895), AKA | The Application of 'Omics... (139635), EC | EUROHEADPAIN (602633), RCUK | Causes of heterogeneity i... (G0902037), NIH | PRECURSORS OF STROKE INCI... (5R01NS017950-05), NIH | Metabolomic predictors of... (1R01DK081572-01),...

    Introduction: Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into mechanisms underlying incident dementia and Alzheimer's disease. Methods: We studied eight prospective cohorts with 22,623 participants profiled by nuclear magnetic resonanc...

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