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21 research outcomes, page 1 of 3
  • publication . Article . 2012
    Open Access English
    Authors:
    Marika Kaakinen; Mikko J. Sillanpää; Marjo-Riitta Jarvelin;
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: AKA | Well-being and health: Re... (104781), AKA | GENETIC REGULATION OF THE... (120315), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), RCUK | Centre for molecular-base... (G0600705), EC | ENGAGE (201413), NIH | Genetic Influences on ADH... (1R01MH063706-01), NIH | Genetics of cardiovascula... (5R01HL087679-02), AKA | Improved methods of lifes... (129418)

    Background The CHRNA5-CHRNA3-CHRNB4 gene cluster on 15q25 has consistently been associated with smoking quantity, nicotine dependence and lung cancer. Recent research also points towards its involvement in cardiovascular homeostasis, but studies in large human samples a...

  • publication . Article . 2016
    Open Access English
    Authors:
    Debbie Lawlor; Antti Kangas; Mika Kähönen; Mika Ala-Korpela; Peter Wurtz;
    Publisher: Springer Nature
    Project: EC | ObesityDevelop (669545), AKA | GENETIC REGULATION OF THE... (120315), WT | Candidate gene variation ... (069224), EC | BIOMARCARE (278913), AKA | The Application of 'Omics... (139635), EC | DYNAHEALTH (633595), RCUK | Centre for molecular-base... (G0600705), AKA | Well-being and health: Re... (104781), AKA | CENTER OF EXCELLENCE IN H... (141136), AKA | Improved methods of lifes... (129269)

    Background Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood. Methods Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to...

  • publication . Article . Conference object . Other literature type . 2017
    Open Access English
    Authors:
    Lachlan Coin; Mika Ala-Korpela;
    Publisher: Springer Nature
    Project: AKA | Well-being and health: Re... (104781), RCUK | Centre for molecular-base... (G0600705), AKA | GENETIC REGULATION OF THE... (120315), RCUK | The central role for andr... (G0802782), EC | EURHEALTHAGEING (277849), AKA | Improved methods of lifes... (129269)

    Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by in...

  • publication . Article . 2014
    Open Access English
    Authors:
    Brendan Zietsch; Sylvain Sebert; Marjo-Riitta Jarvelin;
    Publisher: Public Library of Science
    Project: NIH | Evolutionary Roles of Hom... (5K01MH085812-04), AKA | Well-being and health: Re... (104781), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), WT | Candidate gene variation ... (069224), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Estimating the frequencie... (5R01MH100141-02), RCUK | Centre for molecular-base... (G0600705), AKA | GENETIC REGULATION OF THE... (120315), EC | ENGAGE (201413), NIH | Genetic Influences on ADH... (1R01MH063706-01),...

    Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding inve...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Robin N Beaumont; Sarah J Kotecha; Andrew R. Wood; Bridget A. Knight; Sylvain Sebert; Mark I. McCarthy; Andrew T. Hattersley; Marjo-Riitta Järvelin; Nicholas J. Timpson; Rachel M Freathy; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Centre for molecular-base... (G0600705), AKA | Well-being and health: Re... (104781), RCUK | Bayesian Discovery of Reg... (G1002319), AKA | GENETIC REGULATION OF THE... (120315), AKA | Northern Finland Birth Co... (285547), EC | ENGAGE (201413), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Genetic Influences on ADH... (1R01MH063706-01), WT | The Avon Longitudinal Stu... (217065), EC | DYNAHEALTH (633595),...

    <jats:title>Abstract</jats:title><jats:p>Babies born clinically Small- or Large-for-Gestational-Age (SGA or LGA; sex- and gestational age-adjusted birth weight (BW) &lt;10<jats:sup>th</jats:sup> or &gt;90<jats:sup>th</jats:sup> percentile, respectively), are at higher r...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Ashish Kumar; Ozren Polasek; Peter Joshi; Panos Deloukas; Ian Sayers; Åsa Johansson; Mika Kähönen; Martin Tobin; Stefan Enroth; Deborah Jarvis; ...
    Publisher: Ludwig-Maximilians-Universität München
    Project: SNSF | Swiss Cohort Study on Air... (33CSC0-108796), AKA | Genetic susceptibility an... (255847), RCUK | Bayesian Discovery of Reg... (G1002319), SNSF | SAPALDIA Off-spring study (PMPDP3_129021), AKA | Well-being and health: Re... (104781), MZOS | Determinants of health an... (216-1080315-0302), AKA | MSDs@LIFECOURSE CONSORTIU... (129378), AKA | GENETIC REGULATION OF THE... (120315), AKA | Predicting risk for coron... (251217), RCUK | A program of research in ... (G0902313),...

    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes P...

  • publication . Article . Conference object . Other literature type . 2017
    Open Access English
    Authors:
    Clare Lloyd; David Long; Thanushiyan Poobalasingam; Darcy Wagner; Laura Yates;
    Publisher: The Company of Biologists
    Project: AKA | Well-being and health: Re... (104781), WT | Planar cell polarity in g... (095949), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), RCUK | Centre for molecular-base... (G0600705), NIH | Genetics of cardiovascula... (5R01HL087679-02), AKA | GENETIC REGULATION OF THE... (120315), RCUK | Bayesian Discovery of Reg... (G1002319), RCUK | The role of podocyte thym... (MR/J003638/1), EC | DYNAHEALTH (633595), WT ,...

    ABSTRACT Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), including emphysema, is aberrant tissue repair, which le...

  • publication . Article . 2015
    Open Access English
    Authors:
    Morris, Richard W.; Taylor, Amy E; Fluharty, Meg E; Bjørngaard, Johan H; Åsvold, Bjørn Olav; Elvestad Gabrielsen, Maiken; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; ...
    Publisher: BMJ Publishing Group
    Project: RCUK | The Genetic Epidemiology ... (MR/J012165/1), AKA | CoE in Complex Disease Ge... (213506), NIH | Type 1 Diabetes Genetics ... (1U01DK062418-01), NIH | CHANGES IN HEALTH: SOCIO-... (5R37AG013196-07), NIH | English Longitudinal Stud... (3R01AG017644-14S2), RCUK | Assessment of biomedical ... (G0000934), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), EC | ADDICTION (284167), NIH | Genetics of cardiovascula... (5R01HL087679-02), AKA | Well-being and health: Re... (104781),...

    Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.\ud \ud Design: Mendelian randomisation meta-analyses using a ge...

  • publication . Article . 2012
    Open Access English
    Authors:
    Anokhi Ali Khan; Marika Kaakinen; Alina Rodriguez; Sylvain Sebert; Philippe Froguel; Marjo-Riitta Jarvelin;
    Publisher: Public Library of Science
    Project: RCUK | Centre for molecular-base... (G0600705), AKA | GENETIC REGULATION OF THE... (120315), AKA | Well-being and health: Re... (104781), EC | ENGAGE (201413), AKA | Improved methods of lifes... (129269)

    Background We previously identified via a genome wide association study variants near LEKR and CCNL1 and in the ADCY5 genes lead to lower birthweight. Here, we study the impact of these variants and social stress during pregnancy, defined as social adversity and neighbo...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Michael Sternberg;
    Publisher: Oxford University Press (OUP)
    Project: NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), EC | PERFORM (668303), NIH | JH/CIDR Genotyping for Ge... (5U01HG004438-04), NIH | A Center for GEI Associat... (5U01HG004424-02), NIH | EMR Phenotypes and Commun... (5U01HG004599-02), AKA | Well-being and health: Re... (104781), EC | DYNAHEALTH (633595), NIH | Genome-Wide Study of Cata... (1U01HG004608-01), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Vanderbilt Genome-Electro... (1U01HG004603-01),...

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Motivation</jats:title> <jats:p>Integration of different omics data could markedly help to identify biological signatures, understand the missing heritability of complex diseases and ultimately achieve personalize...

21 research outcomes, page 1 of 3
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