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19 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Kirsi Pietiläinen; Jaakko Kaprio; Johan Gunnar Eriksson; McCarthy MI; Leo-Pekka Lyytikäinen; Mika Ala-Korpela; Mika Kähönen; Peter Wurtz; Antti Kangas;
    Project: WT | Wellcome Trust Sanger Ins... (098051), AKA | CoE in Complex Disease Ge... (213506), AKA | Putting Public Health Gen... (129322), AKA | Center of Excellence in C... (129680), WT | Candidate gene variation ... (069224), AKA | Vitamin D and metabolic h... (139900), AKA | Genetic and environmental... (141054), AKA | A study of aging-related ... (126775), AKA | The Cardiovascular Risk i... (121584), NIH | Genetics of cardiovascula... (5R01HL087679-02),...

    Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of ...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Peter Jones; Graham Murray; Jouko Miettunen;
    Publisher: Cambridge University Press (CUP)
    Project: AKA | GENETIC REGULATION OF THE... (120315), NIH | Genetic Influences on ADH... (1R01MH063706-01), AKA | Trends and interactions o... (268336), NIH | Genetics of cardiovascula... (5R01HL087679-02), EC | EURHEALTHAGEING (277849), EC | ENGAGE (201413), AKA | Well-being and health: Re... (104781), RCUK | Centre for molecular-base... (G0600705), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), RCUK | Bayesian Discovery of Reg... (G1002319),...

    <jats:title>Abstract</jats:title><jats:sec id="S0924933800192004_abs1" sec-type="other"><jats:title>Background</jats:title><jats:p>Delayed motor development in infancy and family history of psychosis are both associated with increased risk of schizophrenia, but their in...

  • publication . Article . 2013
    Open Access
    Authors:
    Stefan Enroth; Alex Couto Alves; Ashish Kumar; Ozren Polasek; Caroline Hayward; Eva Reischl; Lorna M Lopez; Gian Andri Thun; Michele Zorzetto; Victoria Jackson; ...
    Publisher: Public Library of Science (PLoS)
    Project: SNSF | SAPALDIA COHORT STUDY: Mo... (32473B-104288), NIH | Genetic Influences on ADH... (1R01MH063706-01), SNSF | Swiss Study on Air Pollut... (3200-042532), NIH | Genetics of cardiovascula... (5R01HL087679-02), SNSF | Swiss Cohort Study on Air... (33CS30_134276), WT | Cambridge Institute for M... (079895), SNSF | Swiss Cohort Study on Air... (33CSC0-108796), SNSF | The SAPALDIA II Cohort St... (3100-059302), SNSF | Swiss Study on Air Pollut... (3200-052720), SNSF | The SAPALDIA II Cohort St... (3247-065896),...

    Author Summary Low levels of alpha1-antitrypsin (AAT) in the blood are a well-established risk factor for accelerated loss in lung function and chronic obstructive pulmonary disease. While a few infrequent genetic polymorphisms are known to influence the serum levels of...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Terhi Piltonen;
    Publisher: Endocrine society
    Project: AKA | Well-being and health: Re... (104781), RCUK | The central role for andr... (G0802782), AKA | Trends and interactions o... (268336), AKA | Improved methods of lifes... (129269), AKA | GENETIC REGULATION OF THE... (120315)

    We studied psychological distress in women with PCOS symptoms and found high anxiety and depression rates in women with PCOS or isolated hirsutism lasting until perimenopausal age.

  • publication . Preprint . 2017
    Open Access
    Authors:
    Rachel Freathy; mads melbye; Holger Prokisch; Elisabeth Thiering; Paul Elliott; Lachlan Coin; Frank Geller;
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | EMBRYOandLATERHEALTH (648916), NIH | JH/CIDR Genotyping for Ge... (5U01HG004438-04), EC | ENGAGE (201413), NIH | Genome-wide association s... (3U01HG004423-02S1), AKA | GENETIC REGULATION OF THE... (134839), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), AKA | GENETIC REGULATION OF THE... (120315), NIH | Genetic Influences on ADH... (1R01MH063706-01), AKA | Developmental origins of ... (129255), RCUK | Centre for molecular-base... (G0600705),...

    <jats:title>Abstract</jats:title><jats:p>Early childhood growth patterns are associated with adult metabolic health, but the underlying mechanisms are unclear. We performed genome-wide meta-analyses and follow-up in up to 22,769 European children for six early growth ph...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Philippe Amouyel; Grant W Montgomery; David-Alexandre Trégouët; Sara Hägg; Martin Tobin; Kati Kristiansson; Inga Prokopenko; Reedik Mägi; Kirsi Pietiläinen; Jaakko Kaprio; ...
    Project: AKA | Predicting risk for coron... (251217), EC | BIOMARCARE (278913), NIH | Genetic Influences on ADH... (1R01MH063706-01), AKA | Center of Excellence in C... (129680), AKA | Centre of Excellence in R... (272376), NHMRC | Genetics of melanoma risk... (389875), EC | EURHEALTHAGEING (277849), AKA | CoE in Complex Disease Ge... (213506), NHMRC | Genome-wide combined link... (389891), NHMRC | Statistical Methods and A... (389892),...

    Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk f...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Deborah Jarvis; Dipender Gill; Louise Wain; Nick Shrine; Benedicte Leynaert; Ian Hall; Andre F. S. Amaral; Martin Tobin; Nuala Sheehan;
    Publisher: Springer Nature
    Project: RCUK | A program of research in ... (G0902313), RCUK | Centre for molecular-base... (G0600705), NIH | Genetic Influences on ADH... (1R01MH063706-01), RCUK | Defining the genetic cont... (G1000861), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | COMMUNITY BASED STUDY ON ... (5R01HL062633-02), EC | EURHEALTHAGEING (277849), EC | ALEC (633212), EC | DYNAHEALTH (633595), EC | ENGAGE (201413),...

    A trend towards earlier menarche in women has been associated with childhood factors (e.g. obesity) and hypothesised environmental exposures (e.g. endocrine disruptors present in household products). Observational evidence has shown detrimental effects of early menarche...

  • publication . Article . 2014
    Open Access English
    Authors:
    Brendan Zietsch; Sylvain Sebert; Marjo-Riitta Jarvelin;
    Project: NIH | Genetic Influences on ADH... (1R01MH063706-01), AKA | Well-being and health: Re... (104781), EC | ENGAGE (201413), RCUK | Centre for molecular-base... (G0600705), NIH | Estimating the frequencie... (5R01MH100141-02), NIH | Genetics of cardiovascula... (5R01HL087679-02), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), WT | Candidate gene variation ... (069224), AKA | Improved methods of lifes... (129269), AKA | GENETIC REGULATION OF THE... (120315),...

    Across animal species, offspring of closely related mates exhibit lower fitness, a phenomenon called inbreeding depression. Inbreeding depression in humans is less well understood because mating between close relatives is generally rare and stigmatised, confounding inve...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Lachlan Coin; Mika Ala-Korpela;
    Publisher: NATURE PUBLISHING GROUP
    Project: AKA | Well-being and health: Re... (104781), RCUK | Centre for molecular-base... (G0600705), EC | EURHEALTHAGEING (277849), RCUK | The central role for andr... (G0802782), AKA | Improved methods of lifes... (129269), AKA | GENETIC REGULATION OF THE... (120315)

    peerReviewed

  • publication . Article . 2013
    Open Access English
    Authors:
    Francesco CUCCA; Vilmundur Gudnason; Marika Kaakinen; Philipp Koellinger; Johan Gunnar Eriksson; Roy Thurik; Panos Deloukas; Gonneke Willemsen; Jari Marko Tapani Lahti; David Cesarini; ...
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: NIH | CYCLINS AND CHEMICAL CARC... (2R01CA042157-14), FWF | MRI white matter abnormal... (P 13180), AKA | GENETIC REGULATION OF THE... (120315), FWF | Genetics of Cerebral Smal... (P 20545), NIH | Genetic Influences on ADH... (1R01MH063706-01), NWO | NCHA Subsidiebesluit 2008... (2300155116), AKA | DOHaD-Pubertal growth and... (129287), AKA | Well-being and health: Re... (104781), AKA | Improved methods of lifes... (129418), NIH | Health and Retirement Stu... (3U01AG009740-24S2),...

    Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, altho...

19 research outcomes, page 1 of 2
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