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13,209 research outcomes, page 1 of 1,321
  • publication . Article . 2013
    Open Access English
    Authors:
    Michaela Spitzer; Lai Hong Wong; Asier Unciti-Broceta;
    Project: RCUK | HT Chemical Biology - Tra... (G0401194), EC | SCG (233457), WT | A mammalian genetic model... (084637)

    Ability of baker's yeast to arrest cell division reversibly in response to the expression of human telomerase was used to screen for compounds that impaired the enzyme. Wong et al. found several compounds with desired activity, establishing yeast as a model system to id...

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Alfred Cortes; David Baker; Björn F.C. Kafsack; Valerie Crowley; Dominic Kwiatkowski; Cristina Bancells; April Elizabeth Williams; Taane Clark;
    Project: NIH | Imaging Technician (1P50GM071508-01), WT | Wellcome Trust Sanger Ins... (098051), NIH | Regulation of Plasmodium ... (5R01AI076276-02), EC | MALSIG (223044), WT | Understanding the genetic... (090532), RCUK | Genomic analysis of malar... (G0600230)

    The life cycles of many parasites involve transitions between disparate host species, requiring these parasites to go through multiple developmental stages adapted to each of these specialized niches. Transmission of malaria parasites (Plasmodium spp.) from humans to th...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kronbichler, Andreas; Blane, Beth; Holmes, Mark; Wagner, Josef; Parkhill, Julian; Peacock, Sharon; Jayne, David; Harrison, Ewan;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | CARRIAGE: Understanding t... (MR/S00291X/1), WT
  • publication . Article . 2008
    Open Access
    Authors:
    Vincent Bombail; Philippa Saunders;
    Publisher: Oxford University Press (OUP)
    Project: RCUK | Local Cortisol (CORT) Reg... (G0500047)

    BACKGROUND: Estrogen receptor related beta (ERRbeta, ESRRB/NR3B2) is an orphan receptor that shares significant sequence homology with estrogen receptors ERalpha and ERbeta. ERR family members are reported to exhibit constitutive transcriptional activity; however, littl...

  • publication . Article . Conference object . 2016
    Open Access
    Authors:
    Mark Wills; Sarah Elizabeth Jackson; Betty Lau;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Human cytomegalovirus lat... (G0701279)

    Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in inhibition of the lytic viral life cycle. We now show that pharmacological inhibition of hist...

  • publication . Article . 2017
    Open Access English
    Authors:
    Matthew Brookes; George O'Neill; Rosa Sanchez; Paul Glover; Rochelle Ackerley;
    Publisher: Elsevier
    Project: RCUK | Human mechanosensation: F... (MR/M022722/1)

    Highlights • We propose an intra-neural microstimulation system for 7 T fMRI and MEG. • This custom-built system removes issues with existing equipment. • It provides efficient work-flow and improved participant comfort and safety. • Stimulating single mechanoreceptors ...

  • publication . Article . Conference object . Other literature type . 2017
    Open Access English
    Authors:
    Paolo Fusar-Poli; Stefan Borgwardt; Philip McGuire;
    Publisher: Cambridge University Press
    Project: NSF | Hankel and Toeplitz Opera... (0700995), SNSF | Mapping whole-brain struc... (P2ZHP3_155184), RCUK | Social adversity, dopamin... (G0700995)

    <jats:sec id="S0033291716002439_sec_a1"><jats:title>Background</jats:title><jats:p>Impairments in the attribution of salience are thought to be fundamental to the development of psychotic symptoms and the onset of psychotic disorders. The aim of the present study was to...

  • publication . Article . Conference object . Other literature type . 2018
    Open Access
    Authors:
    Ventre, Chiara; Nowell, Sian; Graham, Catriona; Kidd, Doug; Skouras, Christos; Mole, Damian J;
    Publisher: BMJ
    Project: RCUK | Premature death and organ... (MR/P008887/1)

    <jats:sec><jats:title>Introduction</jats:title><jats:p>Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To document organ-specific new...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Hill, Chris H.; Cook, Georgia M.; Spratley, Samantha J.; Graham, Stephen C.; Deane, Janet E.;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Molecular mechanisms of m... (098406), EC | BIOSTRUCT-X (283570), RCUK | Glycosphingolipid recycli... (MR/N020626/1)

    <jats:title>Abstract</jats:title><jats:p>Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin pro...

  • publication . Other literature type . Preprint . 2018
    Open Access
    Authors:
    Iris J. Broce; Chun C. Fan; Nicholas T. Olney; Catherine Lomen-Hoerth; Steve Finkbeiner; Nazem Atassi; Merit E. Cudkowicz; Sabrina Paganoni; Jennifer S. Yokoyama; Aimee Kao; ...
    Publisher: bioRxiv
    Project: RCUK | JPND Biological Resource ... (MR/R024804/1)

    <jats:title>Abstract</jats:title><jats:p>The genetic basis of sporadic amyotrophic lateral sclerosis (ALS) is not well understood. Using large genome-wide association studies and validated tools to quantify genetic overlap, we systematically identified single nucleotide...

13,209 research outcomes, page 1 of 1,321
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