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89 research outcomes, page 1 of 9
  • publication . Article . 2013
    Open Access
    Authors:
    Philippe MAYAUD; Richard Hayes; Saidi Kapiga;
    Project: NIH | Impact and Cost-effective... (1K01MH100994-01), NIH | Clinical and Transtional ... (5KL2TR000143-08), RCUK | Epidemiological and stati... (MR/K012126/1), RCUK | Development of Mwanza Int... (G0901756)

    Highlights • First study to measure impact of malaria and helminth infection on HPV vaccine response. • Study nested within a clinical trial of the HPV-16/18 vaccine in Tanzania. • High prevalence of parasitic infections among Tanzanian girls and young women. • HPV vacc...

  • publication . Article . Conference object . 2018
    Open Access English
    Authors:
    Railey, Ashley F.; Lembo, Tiziana; Palmer, Guy H.; Shirima, Gabriel M.; Marsh, Thomas L.;
    Publisher: Elsevier Science
    Project: RCUK | Towards the strategic con... (BB/H009302/1)

    Highlights • The value of vaccination increases with perceived risk. • Heightened proximity of risk introduces uncertainty. • Household capacity to cope with resource constraints influences vaccination uptake. • Concerns for vaccine efficacy undermine vaccination covera...

  • publication . Article . 2017
    Open Access
    Authors:
    Cleaveland, S.; Sharp, J.; Abela-Ridder, B.; Allan, K.J.; Buza, J.; Crump, J.A.; Davis, A.; Del Rio Vilas, V.J.; de Glanville, W.A.; Kazwala, R.R.; ...
    Project: NIH | Investigating Febrile Dea... (5R01AI121378-02), RCUK | Social, Economic and Envi... (BB/L018926/1), NIH | Viral Zoonoses and Severe... (5K23AI116869-02), WT | Hierarchical epidemiology... (095787), WT | Leptospirosis in Tanzania... (096400), RCUK | The impact and social eco... (BB/J010367/1), WT , RCUK | Hazards Associated with Z... (BB/L017679/1), RCUK | Molecular epidemiology of... (BB/L018845/1)

    This research was supported by the UK Biotechnology and Biological Sciences Research Council (BB/J010367/1) and the UK Zoonoses and Emerging Livestock Systems Initiative (BB/L017679/1, BB/L018926/1 and BB/L018845/1) (S.C., J.E.B.H., J.S., J.B., A.D., J.A.C., W.A.d.G., R...

  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Eric R. Lucas; Kirk A. Rockett; Amy Lynd; John Essandoh; Nelson Grisales; Brigid Kemei; Harun Njoroge; Christina Hubbart; Emily J. Rippon; John Morgan; ...
    Project: WT | Using parasite population... (204911), RCUK | Using spatial statistics ... (MR/P02520X/1), WT | Human Genetics and Diseas... (203141), NIH | Genome-based diagnostics ... (5R01AI116811-02), EC | AVECNET (265660), WT | Resource centre for genom... (090770), WT | Understanding the genetic... (090532), WT

    <jats:title>Abstract</jats:title><jats:p>The spread of resistance to insecticides in the mosquito vectors of diseases such as malaria and dengue poses a threat to the effectiveness of control programmes, which rely largely on insecticide-based interventions. Monitoring ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Paul Kelly; George PrayGod; Andrea Rehman;
    Publisher: BMC
    Project: RCUK | Epidemiological and stati... (MR/K012126/1)

    Background A substantial proportion of HIV-infected adults starting antiretroviral therapy (ART) in sub-Saharan Africa are malnourished. We aimed to increase understanding of the factors affecting their high mortality, particularly in the high-risk period before ART ini...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Umer Zeeshan Ijaz; Viet-Anh Nguyen; Alan W. Walker; Ozan Gundogdu; Christopher Quince;
    Publisher: Wiley-Blackwell Publishing Ltd.
    Project: WT | Wellcome Trust Sanger Ins... (098051), RCUK | Undestanding microbial co... (NE/L011956/1), WT

    Summary Improving the rate and extent of faecal decomposition in basic forms of sanitation such as pit latrines would benefit around 1.7 billion users worldwide, but to do so requires a major advance in our understanding of the biology of these systems. As a critical fi...

  • publication . Article . Preprint . Other literature type . Conference object . 2018
    Open Access
    Authors:
    Sedda, Luigi; Lucas, Eric R.; Djogbénou, Luc S.; Edi, Ako V. C.; Egyir-Yawson, Alexander; Kabula, Bilali I.; Midega, Janet; Ochomo, Eric; Weetman, David; Donnelly, Martin J.;
    Publisher: The Royal Society
    Project: RCUK | Using spatial statistics ... (MR/P02520X/1), RCUK | Data Science of the Natur... (EP/R01860X/1), WT | Identifying, understandin... (110430)

    <jats:p>Vector-borne disease control relies on efficient vector surveillance, mostly carried out using traps whose number and locations are often determined by expert opinion rather than a rigorous quantitative sampling design. In this work we propose a framework for ec...

  • publication . Article . 2012
    Open Access English
    Authors:
    B. Nadjm; Nuno Sepulveda; Taane Clark;
    Publisher: Public Library of Science (PLoS)
    Project: WT | Understanding the genetic... (090532), WT | 'The Global Health Bioeth... (096527), WT | Learning from the human g... (077383), WT | Identification and functi... (075491), WT | Resource centre for genom... (090770), RCUK | Genomic analysis of malar... (G0600230)

    Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe disease. High th...

  • publication . Article . Conference object . 2015
    Open Access
    Authors:
    Nadira Karunaweera; Valentina D Mangano; Síle F Molloy; Sarah Auburn; Deus Ishengoma; Dominic Kwiatkowski; Marita Troye-Blomberg; Nuno Sepulveda; Taane Clark;
    Publisher: BioMed Central
    Project: WT | The health consequences o... (091758), RCUK | MRC Centre for Genomics a... (G0600718), WT | Statistical methods for u... (097364), WT | Cancer Genome Project. (077012), WT | An evidenced based platfo... (091924), WT | Learning from the human g... (077383), WT | Identification and functi... (075491), WT | Understanding the genetic... (090532), WT | Resource centre for genom... (090770), WT

    Background Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologie...

  • publication . Article . Conference object . Other literature type . 2015
    Open Access English
    Authors:
    Felix Lankester; Sarah Cleaveland;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Development of a vaccinat... (BB/H009035/1)

    This study is the first to partially quantify the potential economic benefits that a vaccine, effective at protecting cattle against malignant catarrhal fever (MCF), could accrue to pastoralists living in East Africa. The benefits would result from the removal of househ...

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