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629 research outcomes, page 1 of 63
  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Morales, Hernán E.; Faria, Rui; Johannesson, Kerstin; Larsson, Tomas; Panova, Marina; Westram, Anja M.; Butlin, Roger K.;
    Publisher: American Association for the Advancement of Science (AAAS)
    Project: EC | INVERTIDAL (706376), RCUK | Routes to speciation in L... (NE/P001610/1), EC | BARRIERS (693030), RCUK | Adaptive phenotypes and t... (NE/K014021/1), EC | ISTplus (754411)

    A common genomic architecture allowed a marine snail to rapidly adapt to heterogeneous environments in a replicated way.

  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Yuming Guo; Antonio Gasparrini; Shanshan Li; Francesco Sera; Ana Maria Vicedo-Cabrera; Micheline de Sousa Zanotti Stagliorio Coelho; Paulo Hilario Nascimento Saldiva; Eric Lavigne; Benjawan Tawatsupa; Kornwipa Punnasiri; ...
    Publisher: Public Library of Science (PLoS)
    Project: NHMRC | Understanding and amelior... (1030259), AKA | The Influence of Air Poll... (266314), NHMRC | Environmental exposure, h... (1109193), NHMRC | Advancing the assessment ... (1107107), RCUK | A multi-country analysis ... (MR/M022625/1)

    Background: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. Met...

  • publication . Other literature type . Article . Conference object . 2019
    Open Access
    Authors:
    Salata, Cristiano; Monteil, Vanessa; Karlberg, Helen; Celestino, Michele; Devignot, Stephanie; Leijon, Mikael; Bell-Sakyi, Lesley; Bergeron, Éric; Weber, Friedemann; Mirazimi, Ali;
    Publisher: Taylor & Francis
    Project: RCUK | ANIHWA call 3: ARBONET Ep... (BB/N023889/2), RCUK | The Tick Cell Biobank - a... (BB/P024270/1)

    The DEVD motif of Crimean-Congo hemorrhagic fever virus nucleoprotein is essential for viral replication in tick cells

  • publication . Article . 2019
    Open Access English
    Authors:
    Regina Vontell; Regina Vontell; Veena G. Supramaniam; Alice Davidson; Claire Thornton; Claire Thornton; Andreas Marnerides; Muriel Holder-Espinasse; Suzanne Lillis; Shu Yau; ...
    Publisher: Frontiers Media S.A.
    Project: RCUK | The Developing Brain (MR/K006355/1), WT | Mitochondria-targeted pro... (094823)

    <p>Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which are ectopic nod...

  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Chris J Janse; Oliver Billker; David Baker; Andy Waters;
    Publisher: Public Library of Science
    Project: WT | Experimental genetics of ... (089085), RCUK | A systematic analysis of ... (G0501670)

    Author Summary Malaria parasites are single celled organisms, which must alternate between vertebrate and mosquito hosts to survive and spread. In both hosts, certain parasite stages can glide through tissues and invade cells. Many components of the molecular motor that...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Christoph Freyer; Laura Greaves; Arnaud MOURIER;
    Publisher: Elsevier
    Project: RCUK | University of Newcastle C... (G0700718), WT | Mitochondrial DNA - expre... (096919)

    Summary Mutations of mtDNA are an important cause of human disease, but few animal models exist. Because mammalian mitochondria cannot be transfected, the development of mice with pathogenic mtDNA mutations has been challenging, and the main strategy has therefore been ...

  • publication . Other literature type . Article . 2017 . Embargo End Date: 16 Feb 2017
    Open Access English
    Authors:
    Guy Fagherazzi; Carlo La Vecchia; Valeria Pala; Aurora Perez-Cornago; Signe Borgquist; Elio Riboli; Renée T. Fortner; Elisabete Weiderpass; Anne Tjonneland; Fabrice Bonnet; ...
    Publisher: Apollo - University of Cambridge Repository
    Project: EC | TICE (232997), RCUK | Health of vegetarians (MR/M012190/1)

    What's new? Insulin‐like growth factor I does not appear to influence lymphoma risk, according to new results. IGF‐I can promote some cancers, but there hasn't been a prospective epidemiological study examining the link between IGF‐I concentration and lymphoma risk. To ...

  • publication . Article . Preprint . 2020
    Open Access
    Authors:
    Pascoe, Ben; Schiaffino, Francesca; Murray, Susan; Meric, Guillaume; Bayliss, Sion C; Hitchings, Matthew D; Mourkas, Evangelos; Calland, Jessica K; Burga, Rosa; Yori, Pablo Penataro; ...
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Epidemiology of Shigellos... (5K01TW005717-06), RCUK | The MRC Consortium for Me... (MR/L015080/1), WT | The Genomics of host adap... (088786)

    Campylobacter is the leading bacterial cause of gastroenteritis worldwide and its incidence is especially high in low- and middle-income countries (LMIC). Disease epidemiology in LMICs is different compared to high income countries like the USA or in Europe. Children in...

  • publication . Article . 2020
    Open Access English
    Authors:
    Georgina Krebs;
    Publisher: Elsevier
    Project: RCUK | The role of parental fact... (MR/N001400/1)

    Highlights • ICBT for pediatric OCD was evaluated within three different clinical contexts. • The sample primarily consisted of clinician-referred patients. • The majority of patients completed the treatment and had clinical meaningful effects. • Therapists identified a...

  • publication . Other literature type . Article . 2019
    Open Access
    Authors:
    Lyons, Paul A; Peters, James E; Alberici, Federico; Liley, James; Coulson, Richard M R; Astle, William; Baldini, Chiara; Bonatti, Francesco; Cid, Maria C; Elding, Heather; ...
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | An integrated genetic and... (MR/S004068/1), NHMRC | Integrating Statistical I... (1053756), RCUK | A BIOMARKER AND PATHWAY D... (MR/L019027/1), RCUK | Statistical ‘omics approa... (MC_UU_00002/4), WT | Partitioning autoimmune d... (107881), WT | A new biology of clinical... (200871)

    Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups ...

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