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99 research outcomes, page 1 of 10
  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Kok Lian Ho; Shu Yih Chew;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | MRC Centre for Medical My... (MR/N006364/1), WT | Wellcome Strategic Award ... (097377), RCUK | IMPACT OF FUNGAL ADAPTATI... (MR/M026663/1), RCUK | Mechanisms linking phosph... (BB/P020119/1)

    Abstract The human fungal pathogen Candida glabrata appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathog...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Lai, Sook Ling; Tan, May Leng; Hollows, Robert J.; Robinson, Max; Ibrahim, Maha; Margielewska, Sandra; Parkinson, E. Kenneth; Ramanathan, Anand; Zain, Rosnah Binti; Mehanna, Hisham; ...
    Publisher: MDPI AG
    Project: RCUK | Investigating anti-tumour... (MR/P013201/1)

    <jats:p>Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes squamous cell carcinomas of the oropharynx and oral cavity. Patient prognosis has remained poor for decades and molecular targeted therapies are not in routine u...

  • publication . Article . 2019
    Open Access English
    Authors:
    Cappellini, Enrico; Welker, Frido; Pandolfi, Luca; Ramos-Madrigal, Jazmín; Samodova, Diana; Rüther, Patrick L.; Fotakis, Anna K.; Lyon, David; Moreno-Mayar, J. Víctor; Bukhsianidze, Maia; ...
    Project: RCUK | York-2012-DTG-Funding 7 S... (NE/K500987/1), EC | PEGASUS (681605), EC | Extinction Genomics (681396), RCUK | York-2013-DTG Funding 4 S... (NE/L501761/1), WT , EC | HOPE (795569), EC | TEMPERA (722606)

    Ancient DNA (aDNA) sequencing has enabled reconstruction of speciation, migration, and admixture events for extinct taxa1. Outside the permafrost, however, irreversible aDNA post-mortem degradation2 has so far limited aDNA recovery to the past ~0.5 million years (Ma)3. ...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Christopher Neale; Catharine Ward Thompson;
    Publisher: Springer Science and Business Media LLC
    Project: RCUK | Mobility, Mood and Place:... (EP/K037404/1)

    This research directly assesses older people’s neural activation in response to a changing urban environment whilst walking, as measured by electroencephalography (EEG). The study builds on previous research that shows changes in cortical activity whilst moving through ...

  • publication . Other literature type . Article . 2019
    Open Access English
    Authors:
    Devadoss, Anitha; Forsyth, Rhiannan; Bigham, Ryan; Abbasi, Hina; Ali, Muhammad; Tehrani, Zari; Liu, Yufei; Guy, Owen. J.;
    Publisher: Multidisciplinary Digital Publishing Institute
    Project: EC | SIRCIW (663830), EC | BBDiag (721281), RCUK | Novel Point-of-Care Diagn... (EP/M006301/1), RCUK | Newton Fund - Graphene bi... (102877)

    <jats:p>Grafting thin polymer layers on graphene enables coupling target biomolecules to graphene surfaces, especially through amide and aldehyde linkages with carboxylic acid and primary amine derivatives, respectively. However, functionalizing monolayer graphene with ...

  • publication . Preprint . 2019
    Open Access
    Authors:
    Matthew B. Avison;
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | One Health Drivers of Ant... (MR/S004769/1)

    <jats:title>Abstract</jats:title><jats:p>Meropenem/vaborbactam resistance in <jats:italic>Klebsiella pneumoniae</jats:italic> is associated with loss of function mutations in the OmpK36 porin. Here we identify two previously unknown loss of function mutations that confe...

  • publication . Article . Preprint . 2017
    Open Access English
    Authors:
    Isabel Schlangen; Emmanuel D. Delande; Jeremie Houssineau; Daniel E. Clark;
    Publisher: HAL CCSD
    Project: RCUK | Establishing The Edinburg... (MR/K01563X/1), RCUK | Sensor Signal Processing (EP/J015180/1)

    International audience; The Probability Hypothesis Density (PHD) and Cardinalized PHD (CPHD) filters are popular solutions to the multi-target tracking problem due to their low complexity and ability to estimate the number and states of targets in cluttered environments...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Ahmad, Shiraz; Valli, H; Edling, C; Grace, Andrew; Jeevaratnam, K; Huang, Christopher Li-Hur;
    Publisher: Springer Berlin Heidelberg
    Project: RCUK | Cardiac arrhythmogenesis ... (MR/M001288/1), WT , WT | The role of mitochondrial... (105727)

    A range of chronic clinical conditions accompany cardiomyocyte energetic dysfunction and constitute independent risk factors for cardiac arrhythmia. We investigated pro-arrhythmic and arrhythmic phenotypes in energetically deficient C57BL mice with genetic ablation of t...

  • publication . Preprint . Conference object . 2015
    Open Access English
    Authors:
    Heriberto Cuayahuitl; Simon Keizer; Oliver Lemon;
    Project: EC | STAC (269427), RCUK | Babble: domain-general me... (EP/M01553X/1)

    Artificially intelligent agents equipped with strategic skills that can negotiate during their interactions with other natural or artificial agents are still underdeveloped. This paper describes a successful application of Deep Reinforcement Learning (DRL) for training ...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Calum A. Ross; David G. MacLachlan; Brian Smith; Rainer J. Beck; Jonathan D. Shephard; Nick Weston; Robert R. Thomson;
    Publisher: Preprints
    Project: RCUK | Laser manufacturing dista... (ST/M007839/1)

    <jats:p>Optical biopsy describes a range of medical procedures in which light is used to investigate disease in the body, often in hard-to-reach regions via optical fibres. Optical biopsies can reveal a multitude of diagnostic information to aid therapeutic diagnosis an...

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