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13 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Philip T. James; Ousubie Jawla; Nuredin I. Mohammed; Kabiru Ceesay; Fatai M. Akemokwe; Bakary Sonko; Ebrima A. Sise; Andrew M. Prentice; Matt J. Silver;
    Publisher: Public Library of Science (PLoS)
    Project: RCUK | Impact of maternal diet o... (MC_EX_MR/M01424X/1)

    Background Infant DNA methylation profiles are associated with their mother’s periconceptional nutritional status. DNA methylation relies on nutritional inputs for one-carbon metabolic pathways, including the efficient recycling of homocysteine. This randomised controll...

  • publication . Article . 2018
    Open Access English
    Authors:
    Dominic Kwiatkowski; Roberto Amato; Alfred Amambua-Ngwa;
    Publisher: Nature Publishing Group UK
    Project: RCUK | Plasmodium Falciparum ant... (MC_EX_MR/K02440X/1), WT

    Abstract Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in 2008 and 2014 were analysed to identify changes possibly related to the scale-up of antimalarial interventions that occurred during this period. Overall, there were 15 regions acr...

  • publication . Article . 2014
    Open Access English
    Authors:
    Rockett, Kirk A.; Clarke, Geraldine M.; Fitzpatrick, Kathryn; Hubbart, Christina; Jeffreys, Anna E.; Rowlands, Kate; Craik, Rachel; Jallow, Muminatou; Conway, David J.; Bojang, Kalifa A.; ...
    Project: WT | Identification and functi... (075491), WT | The health consequences o... (091758), EC | EVIMALAR (242095), WT | Statistical methods for u... (097364), WT | Resource centre for genom... (090770), RCUK | MRC Centre for Genomics a... (G0600718), WT | Human genetic polymorphis... (076934), WT | Understanding the genetic... (090532), WT | Cancer Genome Project. (077012), WT | Viet Nam Major Overseas P... (089276),...

    Many human genetic associations with resistance to malaria have been reported but few have been reliably replicated. We collected data on 11,890 cases of severe malaria due to Plasmodium falciparum and 17,441 controls from 12 locations in Africa, Asia and Oceania. There...

  • publication . Preprint . Article . Other literature type . 2017
    Open Access English
    Authors:
    Leffler, Ellen M.; Band, Gavin; Busby, George B. J.; Kivinen, Katja; Le, Quang Si; Clarke, Geraldine M.; Bojang, Kalifa A.; Conway, David J.; Jallow, Muminatou; Sisay-Joof, Fatoumatta; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Understanding the genetic... (090532), RCUK | MRC Centre for Genomics a... (MR/M006212/1), WT | Wellcome Trust Sanger Ins... (098051), EC | EVIMALAR (242095), WT | Statistical methods for u... (097364), WT | Human genetic polymorphis... (076934), WT | Learning from the human g... (077383), WT | The health consequences o... (091758), WT , WT | Developing research capac... (084538),...

    INTRODUCTION Malaria parasites cause human disease by invading and replicating inside red blood cells. In the case of Plasmodium falciparum , this can lead to severe forms of malaria that are a major cause of childhood mortality in Africa. This species of parasite enter...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Oghenebrume Wariri; Bassey Edem; Esin Nkereuwem; Oluwatosin O Nkereuwem; Gregory Umeh; Ed Clark; Olubukola T Idoko; Terna Nomhwange; Beate Kampmann;
    Publisher: BMJ
    Project: RCUK | Vaccines & Immunity R... (MC_UP_A900_1122)

    <jats:sec><jats:title>Background</jats:title><jats:p>Several West African countries are unlikely to achieve the recommended Global Vaccine Action Plan (GVAP) immunisation coverage and dropout targets in a landscape beset with entrenched intra-country equity gaps in immu...

  • publication . Article . 2017
    Open Access English
    Authors:
    Jean-Pierre Van geertruyden; Koen Peeters Grietens; Gian Luca Di Tanna; Teun Bousema; Julia Mwesigwa;
    Publisher: Public Library of Science
    Project: RCUK | Defining malaria transmis... (MC_EX_MR/J002364/1)

    Abstract: Over the last decades, malaria has declined substantially in The Gambia but its transmission has not been interrupted. In order to better target control interventions, it is essential to understand the dynamics of residual transmission. This prospective cohort...

  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    John Britton;
    Publisher: BMJ
    Project: RCUK | The UK Centre for Tobacco... (MR/K023195/1)

    <jats:sec><jats:title>Background</jats:title><jats:p>Annually, 600 000 deaths are attributed to exposure of non-smokers to secondhand smoke (SHS). These include 165 000 among children, about 60% of which occur in Africa and Southeast Asia. As of 2017, only seven countri...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Suzanne Cross; Giorgia Gon; Emma Morrison; Koasar Afsana; Said M. Ali; Tina Manjang; Lamin Manneh; Atiya Rahman; Deepak Saxena; Kranti Vora; ...
    Publisher: Taylor & Francis Group
    Project: RCUK | The Clean Study (MR/R019274/1)

    ABSTRACT Hospital cleaning has been shown to impact on rates of healthcare-associated infections (HCAIs) and good environmental hygiene is critical to quality care, yet those tasked with the role of ensuring a safe and clean environment often go unrecognised as members ...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Alfred Amambua-Ngwa; Mahamadou DIAKITE; Gordon Awandare; Craig W Duffy; Umberto D'Alessandro; Thomas Otto; Hampate Ba;
    Publisher: Nature Publishing Group
    Project: EC | GENINVADE (294428), WT , RCUK | Defining malaria transmis... (MC_EX_MR/J002364/1), WT | Resource centre for genom... (090770), RCUK | Plasmodium Falciparum ant... (MC_EX_MR/K02440X/1), RCUK | Malaria parasite populati... (G1100123)

    Abstract Parasites infect hosts in widely varying environments, encountering diverse challenges for adaptation. To identify malaria parasite genes under locally divergent selection across a large endemic region with a wide spectrum of transmission intensity, genome sequ...

  • publication . Article . 2017
    Open Access English
    Authors:
    Amambua-Ngwa, Alfred; Okebe, Joseph; Mbye, Haddijatou; Ceesay, Sukai; El-Fatouri, Fatima; Joof, Fatou; Nyang, Haddy; Janha, Ramatoulie; Affara, Muna; Ahmad, Abdullahi; ...
    Publisher: American Society for Microbiology
    Project: RCUK | Plasmodium Falciparum ant... (MC_EX_MR/K02440X/1)

    ABSTRACT Antimalarial interventions have yielded a significant decline in malaria prevalence in The Gambia, where artemether-lumefantrine (AL) has been used as a first-line antimalarial for a decade. Clinical Plasmodium falciparum isolates collected from 2012 to 2015 we...

13 research outcomes, page 1 of 2
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