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24 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Barr, Anna; Young, EH; Smeeth, L; Newton, R; Seeley, J; Ripullone, K; Hird, TR; Thornton, JRM; Nyirenda, MJ; Kapiga, S; ...
    Project: WT , RCUK | Research partnership to a... (MR/K013491/1)

    With the changing distribution of infectious diseases, and an increase in the burden of non-communicable diseases, low- and middle-income countries, including those in Africa, will need to expand their health care capacities to effectively respond to these epidemiologic...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Alexander Douglas; Anne Moore; Blandine null; Matthew Dicks; Sarah Gilbert; Chris J Janse; Richard Pleass; Andrew Williams; Simon J Draper;
    Publisher: Nature Publishing Group
    Project: WT | Fully human antibodies fo... (082915), WT | Wellcome Trust PhD Progra... (089455), WT | Human and Veterinary Vacc... (084113), EC | EVIMALAR (242095), RCUK | Clinical and Immunologica... (G1000527), RCUK | The development of a bloo... (G0600424)

    Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoit...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Heloisa Miranda; Nikolaos Fyllas; Bird, Michael I.; Gustavo Saiz; Leandro Maracahipes; Domingues, T.F.; Ted R. Feldpausch; Beatriz Schwantes Marimon; Franziska Schrodt; Gabriela Nardoto; ...
    Publisher: HAL CCSD
    Project: RCUK | Tropical Biomes in Transi... (NE/D005590/1), EC | GEOCARBON (283080)

    Through interpretations of remote-sensing data and/or theoretical propositions, the idea that forest and savanna represent "alternative stable states" is gaining increasing acceptance. Filling an observational gap, we present detailed stratified floristic and structural...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Hayley Tyrer; Mark Taylor; Steve Ward; Hanna Sjoberg; Laura Jessica Myhill; Louise Ford; Joseph Turner; Ghaith Aljayyoussi; Rachel Clare;
    Project: RCUK | Is targeting vascular rem... (MR/L018756/1)

    Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi, Wuchereria bancrofti) or onc...

  • publication . Preprint . Article . Other literature type . 2019
    Open Access
    Authors:
    Lycett, S.; Tanya, V.N.; Hall, M.; King, D.; Mazeri, S.; Mioulet, V.; Knowles, N.; Wadsworth, J.; Bachanek-Bankowska, K.; Ngwa Victor, N.; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: RCUK | Pathogen diversity, host ... (BBS/E/D/20002173)

    Abstract Foot-and-mouth disease (FMD) is a major livestock disease with direct clinical impacts as well as indirect trade implications. Control through vaccination and stamping-out has successfully reduced or eradicated the disease from Europe and large parts of South A...

  • publication . Other literature type . Article . 2009
    Open Access English
    Authors:
    George Christophides; null null; Bogos Agianian; Stephan Meister;
    Project: RCUK | Genomic analysis of NF-ka... (BB/E002641/1), WT | Functional genomic analys... (077229)

    Author Summary Recognition of peptidoglycan on the bacteria cell wall triggers insect immune responses. The fruit fly PGRPLC receptor protein senses the presence of peptidoglycan and activates a pathway that mediates resistance to bacterial infections, mainly Gram-negat...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Ted R. Feldpausch; Martin Dančák; Rahayu Sukmaria Sukri; Simon Lewis; Martin Sullivan; Eric Arets; David Burslem; Beatriz Schwantes Marimon; Faizah Metali; Gabriela Lopez-Gonzalez; ...
    Project: EC | T-FORCES (291585), RCUK | Tropical Biomes in Transi... (NE/D005590/1), EC | AMAZALERT (282664), RCUK | Climate change and the Am... (NE/I021160/1), EC | GEOCARBON (283080)

    © 2018 The Authors. Methods in Ecology and Evolution published by John Wiley & Sons Ltd on behalf of British Ecological Society. Quantifying the relationship between tree diameter and height is a key component of efforts to estimate biomass and carbon stocks in tropical...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Roberto Amato; Dominic Kwiatkowski; Rolland Bantar Tata; Alfred Amambua-Ngwa;
    Project: RCUK | MRC Centre for Genomics a... (G0600718)

    Drug resistance is one of the greatest challenges of malaria control programmes, with the monitoring of parasite resistance to artemisinins or to Artemisinin Combination Therapy (ACT) partner drugs critical to elimination efforts. Markers of resistance to a wide panel o...

  • publication . Preprint . Article . Other literature type . 2016
    Open Access
    Authors:
    Nadira Karunaweera; Sharon E Cox; Sophie Uyoga; Panos Deloukas; Catherine Moyes; George Busby;
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Statistical methods for u... (097364), RCUK | MRC Centre for Genomics a... (MR/M006212/1), RCUK | MRC Centre for Genomics a... (G0600718), WT | Developing research capac... (084538), WT , WT | Wellcome Trust Sanger Ins... (098051), WT | Resource centre for genom... (090770), WT | Understanding the genetic... (090532), WT | Learning from the human g... (077383)

    Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, ana...

  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Dominic Kwiatkowski; Taane Clark;
    Publisher: PUBLIC LIBRARY SCIENCE
    Project: EC | EVIMALAR (242095), RCUK | Genomic analysis of malar... (G0600230), WT | Cancer Genome Project. (077012), WT | Identification and functi... (075491), WT | Learning from the human g... (077383), WT | Resource centre for genom... (090770), WT | Understanding the genetic... (090532), WT | 'The Global Health Bioeth... (096527)

    P. falciparum malaria is one of the most widespread and deadliest infectious diseases in children under five years in endemic areas. The disease has been a strong force for evolutionary selection in the human genome, and uncovering the critical human genetic factors tha...

24 research outcomes, page 1 of 3
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