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449 research outcomes, page 7 of 45
  • publication . Article . 2018
    Open Access English
    Authors:
    Fuady, AM; Tissier, RLM; Houwing-Duistermaat, JJ;
    Publisher: BMC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), EC | MIMOMICS (305280)

    Abstract The main goal of this paper is to estimate the effect of triglyceride levels on methylation of cytosine-phosphate-guanine (CpG) sites in multiple-case families. These families are selected because they have 2 or more cases of metabolic syndrome (primary phenoty...

  • publication . Article . 2018
    Open Access English
    Authors:
    Brian Greco; Alexander Luedtke; Allison Hainline; Carolina Alvarez; Andrew Beck; Nathan L Tintle;
    Publisher: BioMed Central
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Evaluating the Cost Effec... (3R15HG004543-01S2), NIH | Analyzing the behavior an... (2R15HG006915-02), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    Pathway analysis approaches for sequence data typically either operate in a single stage (all variants within all genes in the pathway are combined into a single, very large set of variants that can then be analyzed using standard "gene-based" test statistics) or in 2-s...

  • publication . Article . 2011
    Open Access English
    Authors:
    Barrett Jennifer H; Nsengimana Jérémie;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>We propose a two-stage design for the analysis of sequence variants in which a proportion of genes that show some evidence of association are identified initially and then followed up in an independent data set. We compare two different approaches. In...

  • publication . Article . 2014
    Open Access English
    Authors:
    Derkach, Andriy; Lawless, Jerry F; Merico, Daniele; Paterson, Andrew D; Sun, Lei;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), CIHR , NIH | Discovery of Functional V... (5U01DK085524-05), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    The focus of our work is to evaluate several recently developed pooled association tests for rare variants and assess the impact of different gene annotation methods and binning strategies on the analyses of rare variants under Genetic Analysis Workshop 18 real and simu...

  • publication . Article . 2014
    Open Access English
    Authors:
    Liu, Jin; Huang, Jian; Ma, Shuangge;
    Publisher: BioMed Central
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | Robust rank-based methods... (5R21CA165923-03), NIH | Novel Methods for Integra... (5R01CA142774-03), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Genetic Analysis of Commo... (5R01GM031575-22),...

    We consider analysis of Genetic Analysis Workshop 18 data, which involves multiple longitudinal traits and dense genome-wide single-nucleotide polymorphism (SNP) markers. We use a multivariate linear mixed model to account for the covariance of random effects and multiv...

  • publication . Article . 2014
    Open Access English
    Authors:
    Tanushree Haldar; Indranil Mukhopadhyay; Saurabh Ghosh;
    Publisher: BioMed Central
    Project: NIH | Identifying variants caus... (5U01DK085545-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Unlike case-control studies, family-based tests for association are protected against population stratification. Complex genetic traits are often governed by quantitative precursors and it has been argued that it may be a more powerful strategy to analyze these quantita...

  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Ashley Petersen;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Evaluating the Cost Effec... (3R15HG004543-01S2)

    <p>Abstract</p> <p>A number of rare variant statistical methods have been proposed for analysis of the impending wave of next-generation sequencing data. To date, there are few direct comparisons of these methods on real sequence data. Furthermore, there is a strong nee...

  • publication . Article . 2018
    Open Access English
    Authors:
    Xiaoxi Shen; Qing Lu;
    Publisher: BMC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Computational Efficient S... (5R01DA043501-02), NIH | Methods and Software for ... (1R01LM012848-01)

    Abstract Background Rapidly evolving high-throughput technology has made it cost-effective to collect multilevel omic data in clinical and biological studies. Different types of omic data collected from these studies provide both shared and complementary information, an...

  • publication . Article . 2011
    Open Access English
    Authors:
    Brennan Jennifer S; He Yunxiao; Calixte Rose; Nyirabahizi Epiphanie; Jiang Yuan; Zhang Heping;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | RESEARCH TRAINING IN MENT... (5T32MH014235-14), NIH | Analysis of Genomic Data ... (5R01DA016750-07)

    <p>Abstract</p> <p>Genetic markers with rare variants are spread out in the genome, making it necessary and difficult to consider them in genetic association studies. Consequently, wisely combining rare variants into “composite” markers may facilitate meaningful analyse...

  • publication . Article . 2011
    Open Access English
    Authors:
    Li, Gengxin; Ferguson, John; Zheng, Wei; Lee, Joon; Zhang, Xianghua; Li, Lun; Kang, Jia; Yan, Xiting; Zhao, Hongyu;
    Publisher: BioMed Central
    Project: NIH | Statistical Methods to Ma... (5R01GM059507-08), NIH | YALE BIOMEDICAL SUPERCOMP... (1S10RR019895-01), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Biomedical Informatics an... (5T15LM007056-32)

    <p>Abstract</p> <p>We consider the application of Efron’s empirical Bayes classification method to risk prediction in a genome-wide association study using the Genetic Analysis Workshop 17 (GAW17) data. A major advantage of using this method is that the effect size dist...

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