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845 research outcomes, page 7 of 85
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Jiarui Yang; Chenhui Hu; Ning Guo; Joyita Dutta; Lucia M Vaina; Keith A Johnson; Jorge Sepulcre; Georges El Fakhri; Quanzheng Li;
    Publisher: Nature Publishing Group UK
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Tau Quantitation in AD wi... (5K01AG050711-02), CIHR

    Abstract Amyloid positron emission tomography (PET) imaging is a valuable tool for research and diagnosis in Alzheimer’s disease (AD). Partial volume effects caused by the limited spatial resolution of PET scanners degrades the quantitative accuracy of PET image. In thi...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Coupé, Pierrick; Fonov, Vladimir S.; Bernard, Charlotte; Zandifar, Azar; Eskildsen, Simon F.; Helmer, Catherine; Manjón, José V.; Amieva, Hélène; Dartigues, Jean‐François; Allard, Michèle; ...
    Publisher: HAL CCSD
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | "MR Morphometrics and Cog... (5K01AG030514-02)

    Finding very early biomarkers of Alzheimer's Disease (AD) to aid in individual prognosis is of major interest to accelerate the development of new therapies. Among the potential biomarkers, neurodegeneration measurements from MRI are considered as good candidates but ha...

  • publication . Article . 2019
    Open Access English
    Authors:
    Li, Dan; Iddi, Samuel; Aisen, Paul S; Thompson, Wesley K; Donohue, Michael C;
    Publisher: Elsevier
    Project: NIH | Estimating Long-Term Dise... (1R01AG049750-01A1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Introduction:Clinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models ...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Goukasian, Naira; Hwang, Kristy S.; Romero, Tamineh; Grotts, Jonathan; Do, Triet M.; Groh, Jenna R.; Bateman, Daniel R.; Apostolova, Liana G.;
    Publisher: BMJ Publishing Group
    Project: NIH | UCLA Alzheimers Disease R... (3P50AG016570-07S1), NIH | Imaging epigenetics of Al... (7K02AG048240-03), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08), CIHR , NIH | Imaging and genetic bioma... (5R01AG040770-03)

    <jats:sec><jats:title>Objective</jats:title><jats:p>To investigate the relationship between amyloid burden and frequency of existing and incidence of new neuropsychiatric symptoms (NPS) in elderly with and without cognitive decline.</jats:p></jats:sec><jats:sec><jats:ti...

  • publication . Preprint . 2016
    Open Access English
    Authors:
    Dondelinger, Frank; Mukherjee, Sach; Initiative, The Alzheimer's Disease Neuroimaging;
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Abstract We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the subgroup-level may be lim...

  • publication . Article . 2016
    Open Access English
    Authors:
    Cao, Lei; Wang, Hui-Fu; Tan, Lin; Sun, Fu-Rong; Tan, Meng-Shan; Tan, Chen-Chen; Jiang, Teng; Yu, Jin-Tai; Tan, Lan;
    Publisher: Impact Journals LLC
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Alzheimer's disease (AD) has become a considerable public health issue. The mechanisms underlying AD onset and progression remain largely unclear. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is a strong functional AD candidate gene because it encodes part of...

  • publication . Article . 2016
    Open Access English
    Authors:
    Hu, William T.; Watts, Kelly D.; Tailor, Prashant; Nguyen, Trung P.; Howell, Jennifer C.; Lee, Raven C.; Seyfried, Nicholas T.; Gearing, Marla; Hales, Chadwick M.; Levey, Allan I.; ...
    Publisher: BioMed Central
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | 1995 SUMMER INSTITUTE IN ... (1R13AG013039-01), CIHR , NIH | Early CSF detection of FT... (5K23AG042856-02), NIH | ALZHEIMERS DISEASE DATA C... (5U01AG016976-03)

    Introduction CSF levels of established Alzheimer’s disease (AD) biomarkers remain stable despite disease progression, and non-amyloid non-tau biomarkers have the potential of informing disease stage and progression. We previously identified complement 3 (C3) to be decre...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    St John-Williams, Lisa; Blach, Colette; Toledo, Jon B.; Rotroff, Daniel M.; Kim, Sungeun; Klavins, Kristaps; Baillie, Rebecca; Han, Xianlin; Mahmoudiandehkordi, Siamak; Jack, John; ...
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , NIH | TDP-43 Proteinopathies in... (5P01AG032953-02), NIH | Metabolic Networks and Pa... (5R01AG046171-03), NIH | Parkinsons Disease and De... (3P50NS053488-02S1), NIH | Alzheimers Disease Center... (2P30AG010124-11)

    Alzheimer’s disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease path...

  • publication . Article . 2017
    Open Access English
    Authors:
    Sepideh Shokouhi; William Riddle; Hakmook Kang;
    Publisher: Dove Medical Press
    Project: NIH | In vivo Amyloid-Beta Imag... (5R00EB009106-04), CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Sepideh Shokouhi,1 William R Riddle,1,&amp;dagger; Hakmook Kang2 1Department of Radiology &amp;amp; Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 2Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA &a...

  • publication . Article . Preprint . 2019
    Open Access English
    Authors:
    Taeho Jo; Taeho Jo; Taeho Jo; Kwangsik Nho; Kwangsik Nho; Kwangsik Nho; Andrew J. Saykin; Andrew J. Saykin; Andrew J. Saykin;
    Publisher: Frontiers Media S.A.
    Project: NIH | Older Breast Cancer Patie... (5R01CA129769-09), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Neurogenesis in Adult Bra... (5R03AG054936-02), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Leveraging Neuroimaging B... (1R01AG057739-01A1), NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08), NIH | Integrating Neuroimaging,... (1R01LM012535-01)

    Deep learning, a state-of-the-art machine learning approach, has shown outstanding performance over traditional machine learning in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep le...

845 research outcomes, page 7 of 85
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