Filters (2 )
Download Results
449 research outcomes, page 6 of 45
  • publication . Article . Conference object . 2009
    Open Access
    Authors:
    Wei Yang;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | VARIABLE SELECTION IN GEN... (1R01HL091028-01A1)

    <p>Abstract</p> <p>Genetic analysis of complex diseases demands novel analytical methods to interpret data collected on thousands of variables by genome-wide association studies. The complexity of such analysis is multiplied when one has to consider interaction effects,...

  • publication . Article . 2011
    Open Access English
    Authors:
    Liping Tong; Bamidele Tayo; Jie Yang; Richard S Cooper;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Genetics of Hypertension ... (5R01HL053353-15)

    <p>Abstract</p> <p>We compare the SNP-based and gene-based association studies using 697 unrelated individuals. The Benjamini-Hochberg procedure was applied to control the false discovery rate for all the multiple comparisons. We use a linear model for the single-nucleo...

  • publication . Article . 2009
    Open Access
    Authors:
    Callegaro Andrea; Uh Hae-Won; Helmer Quinta; Houwing-Duistermaat Jeanine J;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>Our aim is to develop methods for mapping genes related to age at onset in general pedigrees. We propose two score tests, one derived from a gamma frailty model with pairwise likelihood and one derived from a log-normal frailty model with approximated...

  • publication . Article . 2011
    Open Access English
    Authors:
    Hinrichs, Anthony L; Culverhouse, Robert C; Suarez, Brian K;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Statistical Methods for t... (5K01AA015572-04), NIH | GENETIC INTERACTIONS CONT... (1R03DA023166-01A1), NIH | Computational Methods to ... (5K25GM069590-03)

    We report two approaches for linkage analysis of data consisting of replicate phenotypes. The first approach is specifically designed for the unusual (in human data) replicate structure of the Genetic Analysis Workshop 17 pedigree data. The second approach consists of a...

  • publication . Article . 2011
    Open Access
    Authors:
    Yip Wai-Ki; De Gourab; Raby Benjamin A; Laird Nan;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | FAMILY BASED TESTS OF ASS... (5R01MH059532-02), NIH | Novel Statistical Approac... (5R01MH081862-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | A New Approach to Mental ... (5R01MH087590-04)

    <p>Abstract</p> <p>Linkage- and association-based methods have been proposed for mapping disease-causing rare variants. Based on the family information provided in the Genetic Analysis Workshop 17 data set, we formulate a two-pronged approach that combines both methods....

  • publication . Article . Conference object . 2016
    Open Access English
    Authors:
    Marcio Augusto Afonso de Almeida;
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Discovering More Juvenile... (3R01NS055057-01A2S1), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    Abstract High-density genetic marker data, especially sequence data, imply an immense multiple testing burden. This can be ameliorated by filtering genetic variants, exploiting or accounting for correlations between variants, jointly testing variants, and by incorporati...

  • publication . Article . Other literature type . 2009
    Open Access English
    Authors:
    Mary Feitosa;
    Publisher: BioMed Central
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Fifteen known type 2 diabetes (T2D) gene variants were assessed for their associations with T2D status in 228 T2D families from the Framingham Heart Study (FHS) Original, Offspring, and Children Cohorts. Bayesian approach was used to test single-single-nucleotide polymo...

  • publication . Article . Other literature type . 2011
    Open Access English
    Authors:
    Liu, Ying; Huang, Chien-Hsun; Hu, Inchi; Zheng, Tian; Lo, Shaw-Hwa;
    Publisher: Springer Nature
    Project: NSF | Collaborative Research: A... (0714669), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | New Approach Towards Mapp... (5R01GM070789-04)

    Both common variants and rare variants are involved in the etiology of most complex diseases in humans. Developments in sequencing technology have led to the identification of a high density of rare variant single-nucleotide polymorphisms (SNPs) on the genome, each of w...

  • publication . Article . 2016
    Open Access English
    Authors:
    Ya-Jing Zhou; Yong Wang; Li-Li Chen;
    Publisher: MDPI
    Project: NIH | QUANTITATIVE TRAIT LOCUS ... (5R01MH059490-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Next-generation sequencing technology has made it possible to detect rare genetic variants associated with complex human traits. In recent literature, various methods specifically designed for rare variants are proposed. These tests can be broadly classified into burden...

  • publication . Article . 2011
    Open Access English
    Authors:
    Ding Lili; Baye Tesfaye M; He Hua; Zhang Xue; Kurowski Brad G; Martin Lisa J;
    Publisher: BioMed Central
    Project: NIH | REHABILITATION MEDICINE S... (5K12HD001097-02), NIH | Genetic and Environmental... (5R01NS036695-14), NIH | Admixture mapping in Afri... (5K01HL103165-02), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Genetic Mechanisms of Car... (5K24HL069712-07)

    <p>Abstract</p> <p>We propose a nonparametric Bayes-based clustering algorithm to detect associations with rare and common single-nucleotide polymorphisms (SNPs) for quantitative traits. Unlike current methods, our approach identifies associations with rare genetic vari...

449 research outcomes, page 6 of 45
Last index information