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845 research outcomes, page 6 of 85
  • publication . Article . 2017
    Open Access
    Authors:
    Nedelska, Zuzana; Przybelski, Scott A.; Lesnick, Timothy G.; Schwarz, Christopher G.; Lowe, Val J.; Machulda, Mary M.; Kremers, Walter K.; Mielke, Michelle M.; Roberts, Rosebud O.; Boeve, Bradley F.; ...
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Project: NIH | Stroke and Cognitive Impa... (5R01AG037551-03), NIH | Virotherapy for Relapsed ... (5R01CA125614-05), NIH | Longitudinal multi-modali... (5R01DC012519-03), NIH | Aerobic Exercise in Alzhe... (1R01AG043392-01A1), NIH | ALZHEIMERS DISEASE DATA C... (5U01AG016976-03), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Sphingolipids and Inflamm... (1R01AG049704-01), NIH | Hedgehog EGF Pathway Inte... (5P50CA102701-10), NIH | A Phase II Evaluation of ... (5R01CA200551-02), NIH | Imaging for Cellular Sene... (5R21AG047984-02),...

    <jats:sec><jats:title>Objective:</jats:title><jats:p>To assess whether noninvasive proton magnetic resonance spectroscopy (<jats:sup>1</jats:sup>H-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of β-amyloid (Aβ) accumulation on seria...

  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Verma, Nishant; Beretvas, S. Natasha; Pascual, Belen; Masdeu, Joseph C.; Markey, Mia K.;
    Publisher: BioMed Central
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Introduction As currently used, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) has low sensitivity for measuring Alzheimer’s disease progression in clinical trials. A major reason behind the low sensitivity is its sub-optimal scoring methodology,...

  • publication . Article . 2017
    Open Access English
    Authors:
    Dragan Gamberger; Nada Lavrač; Shantanu Srivatsa; Rudolph E. Tanzi; P. Murali Doraiswamy;
    Publisher: Nature Publishing Group UK
    Project: HRZZ | Machine learning algorith... (IP-2013-11-9623), EC | MAESTRA (612944), EC | HBP (604102), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , NIH | Identification and Charac... (5R37MH060009-06), EC | INNOMOL (316289), NIH | A novel human 3D neural c... (1RF1AG048080-01)

    The heterogeneity of Alzheimer’s disease contributes to the high failure rate of prior clinical trials. We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) using a novel mult...

  • publication . Article . 2014
    Open Access English
    Authors:
    Zieselman, Amanda L; Fisher, Jonathan M; Hu, Ting; Andrews, Peter C; Greene, Casey S; Shen, Li; Saykin, Andrew J; Moore, Jason H;
    Publisher: BioMed Central
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Bioinformatics Strategies... (5R01LM011360-03), NIH | Bioinformatics Strategies... (5R01LM010098-08), CIHR , NIH | Administrative Core (2P20GM103506-06), NIH | Quantitative Biology Rese... (5P20GM103534-04)

    Background Alzheimer’s disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the ...

  • publication . Preprint . 2019
    Open Access English
    Authors:
    Gafuroglu, Can; Rekik, Islem;
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Patients initially diagnosed with early mild cognitive impairment (eMCI) are known to be a clinically heterogeneous group with very subtle patterns of brain atrophy. To examine the boarders between normal controls (NC) and eMCI, Magnetic Resonance Imaging (MRI) was exte...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Willette, Auriel A.; Modanlo, Nina; Kapogiannis, Dimitrios;
    Publisher: American Diabetes Association
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Alzheimer disease (AD) is characterized by progressive hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans. Peripheral insulin resistance (IR) increases AD risk. No studies have examined associations between FDG metabolism and IR in m...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Elaheh Moradi; Ilona Hallikainen; Tuomo Hänninen; Jussi Tohka;
    Publisher: Elsevier BV
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), EC | CONEX (600371)

    Rey’s Auditory Verbal Learning Test (RAVLT) is a powerful neuropsychological tool for testing episodic memory, which is widely used for the cognitive assessment in dementia and pre-dementia conditions. Several studies have shown that an impairment in RAVLT scores reflec...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Therriault Joseph; Ng Kok Pin; Pascoal Tharick A.; Mathotaarachchi Sulantha; Kang Min Su; Struyfs Hanne; Shin Monica; Benedet Andrea L.; Walpola Ishan C.; Nair Vasavan; ...
    Publisher: Lippincott Williams & Wilkins
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Abstract: Objective To identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment. Methods We stratified 468 patients with amnestic mild cognitive impairment into intact and impaired awareness gro...

  • publication . Preprint . 2015
    Open Access English
    Authors:
    Li, Rui; Perneczky, Robert; Drzezga, Alexander; Kramer, Stefan;
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    We present a method to discover interesting brain regions in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, showing also the benefits when PET scans are in combined use with non-imaging variables. The discriminative brain regions facilitate a better ...

  • publication . Article . Other literature type . 2019
    Open Access
    Authors:
    Horgusluoglu-Moloch, Emrin; Risacher, Shannon L.; Crane, Paul K.; Hibar, Derrek; Thompson, Paul M.; Saykin, Andrew J.; Nho, Kwangsik; Alzheimer’s Disease Neuroimaging Initiative (ADNI);
    Publisher: eScholarship, University of California
    Project: NIH | Bio-behavioral Research A... (5R35CA197289-04), NIH | Integrating Neuroimaging,... (1R01LM012535-01), NIH | Older Breast Cancer Patie... (5R01CA129769-09), NIH | Bioinformatics Strategies... (5R01LM011360-03), NIH | ENIGMA Center for Worldwi... (3U54EB020403-04S1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , NSF | III: Small: Collaborative... (1117335), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Neurogenesis in Adult Bra... (5R03AG054936-02),...

    Abstract Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrich...

845 research outcomes, page 6 of 85
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