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449 research outcomes, page 5 of 45
  • publication . Article . 2014
    Open Access
    Authors:
    Blackburn, August N; Dean, Angela K; Lehman, Donna M;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    Whole genome sequencing (WGS) remains prohibitively expensive, which has encouraged the development of methods to impute WGS data into nonsequenced individuals using a framework of single nucleotide polymorphisms genotyped for genome-wide association studies (GWAS). Alt...

  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Peralta, Juan M.; Blackburn, Nicholas B.; Porto, Arthur; Blangero, John; Charlesworth, Jac;
    Publisher: BMC
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    Abstract We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent...

  • publication . Article . 2014
    Open Access English
    Authors:
    Hinrichs, Anthony L; Culverhouse, Robert C; Suarez, Brian K;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), NIH | Discovery of Functional V... (5U01DK085524-05), NIH | DEVELOPING STRATEGIES FOR... (1R21DA033827-01), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | Identifying variants caus... (5U01DK085545-02), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04)

    The ideal genetic analysis of family data would include whole genome sequence on all family members. A strategy of combining sequence data from a subset of key individuals with inexpensive, genome-wide association study (GWAS) chip genotypes on all individuals to infer ...

  • publication . Article . 2018
    Open Access English
    Authors:
    Chong Wu; Jun Young Park; Weihua Guan; Wei Pan;
    Publisher: BioMed Central
    Project: NIH | Statistical Methods for G... (9R01GM113250-11A1), NIH | Genetic Association and P... (5R01HL105397-06), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Association analysis of r... (5R01HL116720-05)

    Abstract DNA methylation plays an important role in normal human development and disease. In epigenome-wide association studies (EWAS), a univariate test for association between a phenotype and each cytosine-phosphate-guanine (CpG) site has been widely used. Given the n...

  • publication . Article . 2016
    Open Access English
    Authors:
    Taebeom Kim; Peng Wei;
    Publisher: BioMed Central
    Project: NIH | Genetic Susceptibility an... (4R01CA169122-04), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Association analysis of r... (5R01HL116720-05), NIH | Genome-wide gene-by-smoki... (1R21HL126032-01)

    With the rapidly decreasing cost of the next-generation sequencing technology, a large number of whole genome sequences have been generated, enabling researchers to survey rare variants in the protein-coding and regulatory regions of the genome. However, it remains a da...

  • publication . Article . 2016
    Open Access English
    Authors:
    Jonathan Auerbach; Michael Agne; Rachel Fan; Adeline Lo; Shaw-Hwa Lo; Tian Zheng; Pei Wang;
    Publisher: Springer Nature
    Project: NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    We propose a new method for identifying disease-related regions of single nucleotide variants in recently admixed populations. We use principal component analysis to derive both global and local ancestry information. We then use the summation partition approach to searc...

  • publication . Article . 2009
    Open Access
    Authors:
    Allen Andrew S; Satten Glen A;
    Publisher: Springer Nature
    Project: NIH | Advanced Haplotype Analys... (1K25HL077663-01), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | Robust Methods for the Ef... (1R01MH084680-01)

    <p>Abstract</p> <p>We present computationally simple association tests based on haplotype sharing that can be easily applied to genome-wide association studies, while allowing use of fast (but not likelihood-based) haplotyping algorithms, and properly accounting for the...

  • publication . Article . 2009
    Open Access
    Authors:
    Maenner, Matthew J; Denlinger, Loren C; Langton, Asher; Meyers, Kristin J; Engelman, Corinne D; Skinner, Halcyon G;
    Publisher: Springer Nature
    Project: NIH | Variant Nucleotide Recept... (1K23HL081492-01A2), NIH | Prospective Studies of Pa... (5K07CA109361-06), NIH | Genetic Analysis of Commo... (5R01GM031575-22)

    <p>Abstract</p> <p>Background</p> <p>Genome-wide association studies are often limited in their ability to attain their full potential due to the sheer volume of information created. We sought to use the random forest algorithm to identify single-nucleotide polymorphism...

  • publication . Article . 2014
    Open Access English
    Authors:
    Chen, Zhijian; Tan, Kuan-Rui; Bull, Shelley B;
    Publisher: BioMed Central
    Project: NIH | Identifying T2D Variants ... (1U01DK085584-01), NIH | Identification and Replic... (5U01DK085501-02), CIHR , NIH | Discovery of Functional V... (5U01DK085524-05), NIH | Genetic Analysis of Commo... (5R01GM031575-22), NIH | GENETICS OF GALLBLADDER D... (5R01DK053889-04), NIH | Identifying variants caus... (5U01DK085545-02), NIH | Multiethnic Study of Type... (5U01DK085526-05), NIH | NIDDM Susceptibility Gene... (5R01DK047482-13)

    We apply a multiphase strategy for pedigree-based genetic analysis of systolic blood pressure data collected in a longitudinal study of large Mexican American pedigrees. In the first phase, we conduct variance-components linkage analysis to identify regions that may har...

  • publication . Article . 2009
    Open Access English
    Authors:
    Aporntewan Chatchawit; Ballard David H; Lee Ji; Lee Joon; Wu Zheyang; Zhao Hongyu;
    Publisher: BioMed Central
    Project: NIH | Biomedical Informatics an... (5T15LM007056-32), NIH | Genetic Analysis of Commo... (5R01GM031575-22), WT , NIH | Thai-US Drug Dependence G... (5D43TW006166-03)

    <p>Abstract</p> <p>We propose to use the rough set theory to identify genes affecting rheumatoid arthritis risk from the data collected by the North American Rheumatoid Arthritis Consortium. For each gene, we employ generalized dynamic reducts in the rough set theory to...

449 research outcomes, page 5 of 45
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