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846 research outcomes, page 5 of 85
  • publication . Preprint . 2019
    Open Access
    Authors:
    Zhao, Bingxin; Luo, Tianyou; Li, Tengfei; Li, Yun; Zhang, Jingwen; Shan, Yue; Wang, Xifeng; Yang, Liuqing; Zhou, Fan; Zhu, Ziliang; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Neurodevelopmental Genomi... (5RC2MH089983-02), NIH | Mapping the Human Connect... (3U54MH091657-03S1), NIH | Creating a Pediatric Imag... (3RC2DA029475-02S1), NIH | 2/2 Neurodevelopmental Ge... (5RC2MH089924-02), NIH | Statistical Analysis of B... (5R01MH086633-03), NIH | Analysis of Big Data Squa... (1R01MH116527-01)

    <jats:title>Abstract</jats:title><jats:p>Volumetric variations of human brain are heritable and are associated with many brain-related complex traits. Here we performed genome-wide association studies (GWAS) and post-GWAS analyses of 101 brain volumetric phenotypes usin...

  • publication . Article . Other literature type . 2012
    Open Access English
    Authors:
    Zhijun Yao; Bin Hu; Chuanjiang Liang; Lina Zhao; Mike Jackson; Alzheimer's Disease Neuroimaging Initiative;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | CORE-- CLINICAL (3P30AG010129-11S1), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | "MR Morphometrics and Cog... (5K01AG030514-02), EC | OPTIMI (248544)

    In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In t...

  • publication . Preprint . 2020
    Open Access English
    Authors:
    Gonneaud, Julie; Baria, Alex T.; Binette, Alexa Pichet; Gordon, Brian A.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Jucker, Mathias; Levin, Johannes; Salloway, Stephen; Farlow, Martin; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | DIAN Genetics Core (5U19AG032438-03), CIHR

    Abstract We aimed at developing a model able to predict brain aging from resting state functional connectivity (rs-fMRI) and assessing whether genetic risk/determinants of Alzheimer’s disease (AD) and amyloid (Aβ) pathology contributes to accelerated brain aging. Using ...

  • publication . Article . 2017
    Open Access English
    Authors:
    Singanamalli, Asha; Wang, Haibo; Madabhushi, Anant; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford; Jagust, William; Trojanowki, John; Toga, Arthur; ...
    Publisher: eScholarship, University of California
    Project: NIH | Pathology Image Informati... (1U24CA199374-01), NIH | MR Fingerprinting and Com... (5R01CA208236-02), NIH | Computerized morphologic-... (1R21CA195152-01), NIH | Histologic image-based ag... (5R21CA179327-02), NIH | Computerized histologic i... (5R01CA202752-03), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR , NIH | BIOMEDICAL ENGINEERING RE... (1C06RR012463-01), NIH | Comprehensive quantitativ... (5R01DK098503-02)

    The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer’s Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    de Sitter, A.; Visser, M.; Brouwer, I.; Cover, K. S.; van Schijndel, R. A.; Eijgelaar, R. S.; Müller, D. M. J.; Ropele, S.; Kappos, L.; Rovira, Á.; ...
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Background Recent studies have created awareness that facial features can be reconstructed from high-resolution MRI. Therefore, data sharing in neuroimaging requires special attention to protect participants’ privacy. Facial features removal (FFR) could alleviate these ...

  • publication . Article . 2020
    Open Access English
    Authors:
    Bigham, Bahare; Zamanpour, Seyed Amir; Zemorshidi, Fariba; Boroumand, Farzaneh; Zare, Hoda;
    Publisher: IOS Press
    Project: CIHR , NIH | Alzheimers Disease Neuroi... (1U01AG024904-01)

    Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integrity of the superficial white matter (SWM) in the ...

  • publication . Conference object . Preprint . 2019
    Open Access English
    Authors:
    Ostertag, C.; Beurton-Aimar, M.; Urruty, T.;
    Publisher: HAL CCSD
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract features from whole-brain 3D MRI i...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Pascoal, T A; Mathotaarachchi, S; Mohades, S; Benedet, A L; Chung, C-O; Shin, M; Wang, S; Beaudry, T; Kang, M S; Soucy, J-P; ...
    Publisher: Nature Publishing Group
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    This study was designed to test the interaction between amyloid-β and tau proteins as a determinant of metabolic decline in preclinical Alzheimer's disease (AD). We assessed 120 cognitively normal individuals with [18F]florbetapir positron emission tomography (PET) and ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Laura Caberlotto; Luca Marchetti; Mario Lauria; Marco Scotti; Silvia Parolo;
    Publisher: Nature Publishing Group
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | National Brain and Tissue... (5U24NS072026-03), NIH | Plasma AB as a Surrogate ... (5R01AG018023-10), NIH | ALZHEIMERS DISEASE PATIEN... (2U01AG006786-04), NIH | Gene discovery in PSP by ... (3R01NS080820-02S1), NIH | Mayo Alzheimers Disease R... (3P50AG016574-06S1), NIH | Genome wide association s... (5R01AG032990-02), CIHR , NIH | Education and Information... (2P30AG019610-11), NIH | A system approach to targ... (5U01AG046139-03)

    Among the genetic factors known to increase the risk of late onset Alzheimer’s diseases (AD), the presence of the apolipoproteine e4 (APOE4) allele has been recognized as the one with the strongest effect. However, despite decades of research, the pathogenic role of APO...

  • publication . Article . 2015
    Open Access English
    Authors:
    Jingwen eYan; Jingwen eYan; Sungeun eKim; Sungeun eKim; Kwangsik eNho; Kwangsik eNho; Rui eChen; Rui eChen; Shannon L. Risacher; Shannon L. Risacher; ...
    Publisher: Frontiers Media S.A.
    Project: NIH | Bioinformatics Strategies... (5R01LM011360-03), NSF | III: Small: Collaborative... (1117335), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NIH | Bioinformatics Strategies... (5R01LM010098-08), NIH | Amyloid Imaging, VMCI, an... (1RC2AG036535-01), NIH | Memory Circuitry in MCI a... (2R01AG019771-06), NIH | Machine Learning Predicti... (5R01LM009012-08), CIHR , NIH | CORE-- EDUCATION AND INFO... (5P30AG010133-08), NIH | Indiana Clinical and Tran... (3UL1TR001108-02S1)

    As the most common type of dementia, Alzheimer’s disease (AD) is a neurodegenerative disorder initially manifested by impaired memory performances. While the diagnosis information indicates a dichotomous status of a patient, memory scores have the potential to capture t...

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