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109 research outcomes, page 5 of 11
  • publication . Article . 2014
    Open Access English
    Authors:
    Robinson, M.W.; Swann, R.; Sigruener, A.; Barclay, S.T.; Mills, P.R.; McLauchlan, J.; Patel, A. H.;
    Publisher: John Wiley & Sons Ltd.
    Project: EC | LIPIDOMICNET (202272)

    Hepatitis C virus (HCV) can be classified into seven distinct genotypes that are associated with differing pathologies and respond differently to antiviral therapy. In the UK, genotype 1 and 3 are present in approximately equal proportions. Chronic infection with HCV ge...

  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Alexander Sigruener; Christian Wolfrum; Alfred Boettcher; Thomas Kopf; Gerhard Liebisch; Evelyn Orsó; Gerd Schmitz;
    Publisher: Public Library of Science
    Project: EC | LIPIDOMICNET (202272)

    Background Sequence variants near the human gene for P4-type ATPase, class V, type 10D (ATP10D) were shown to significantly associate with circulating hexosylceramide d18:1/16:0 and d18:1/24:1 levels, obesity, insulin resistance, plasma high density lipoprotein (HDL), c...

  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Taskinen, M.-R.; Adiels, M.; Westerbacka, J.; Soderlund, S.; Kahri, J.; Lundbom, N.; Lundbom, J.; Hakkarainen, A.; Olofsson, S.-O.; Orho-Melander, M.; ...
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Project: EC | ETHERPATHS (222639), EC | LIPIDOMICNET (202272)

    Objective— Obesity increases the risk of cardiovascular disease and premature death. However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjec...

  • publication . Doctoral thesis . 2013
    Open Access English
    Authors:
    Vroegrijk, Irene Olga Cornelia Maria;
    Publisher: Department of Endocrinology and Metabolic Diseases, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
    Project: EC | LIPIDOMICNET (202272)

    The metabolic syndrome is a multi-component condition that includes obesity hypertriglyceridemia and insulin resistance. The prevalence of the metabolic syndrome is rising world-wide and is associated with an increased risk for the development of cardiovascular diseases...

  • publication . Article . 2012
    Open Access
    Authors:
    Matysik, S.; Klunemann, H. H.; Schmitz, G.;
    Publisher: Oxford University Press (OUP)
    Project: EC | LIPIDOMICNET (202272)

    <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Cholesterol precursors and plant sterols have considerable potential as plasma biomarkers in several disorders of sterol metabolism and intestinal sterol absorption. Oxysterols are associated with atherogenesis, neu...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Hynynen Riikka; Suchanek Monika; Spandl Johanna; Bäck Nils; Thiele Christoph; Olkkonen Vesa M.;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: EC | LIPIDOMICNET (202272)

    Oxysterol binding protein-related protein 2 (ORP2) is a member of the oxysterol binding protein family, previously shown to bind 25-hydroxycholesterol and implicated in cellular cholesterol metabolism. We show here that ORP2 also binds 22(R)-hydroxycholesterol [22(R)OHC...

  • publication . Doctoral thesis . 2013
    Open Access English
    Authors:
    Mesman, R.J.;
    Project: EC | LIPIDOMICNET (202272)

    Lipids are essential for cellular life, functioning either organized as bilayer membranes to compartmentalize cellular processes, as signaling molecules or as metabolic energy storage. Our current knowledge on lipid organization and cellular lipid homeostasis is mainly ...

  • publication . Article . 2011
    Open Access English
    Authors:
    Radner, Franz PW; Grond, Susanne; Haemmerle, Guenter; Lass, Achim; Zechner, Rudolf;
    Publisher: Landes Bioscience
    Project: EC | TOBI (201608), EC | LIPIDOMICNET (202272)

    Keratinocyte differentiation is essential for skin development and the formation of the skin permeability barrier. This process involves an orchestrated remodeling of lipids. The cleavage of precursor lipids from lamellar bodies by β-glucocerebrosidase, sphingomyelinase...

  • publication . Conference object . Article . Other literature type . 2015
    Open Access English
    Authors:
    Marta Krystyna Kosinska; Taryn E Ludwig; Gerhard Liebisch; Ruiyan Zhang; Hans-Christian Siebert; Jochen Wilhelm; Ulrich Kaesser; Reinhard B Dettmeyer; Heiko Klein; Bernd Ishaque; ...
    Publisher: German Medical Science GMS Publishing House; Düsseldorf
    Project: EC | LIPIDOMICNET (202272)

    Background Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data about the molecular...

  • publication . Article . 2011
    Open Access English
    Authors:
    Clark, Jonathan; Anderson, Karen E; Juvin, Veronique; Smith, Trevor S; Karpe, Fredrik; Wakelam, Michael J O; Stephens, Len R; Hawkins, Phillip T;
    Project: RCUK | Regulation of superoxide ... (BBS/E/B/0000C218), EC | LIPIDOMICNET (202272)

    Class I phosphoinositide-3-kinase (PI3K) isoforms generate the intracellular signaling lipid, phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P 3). PtdIns(3,4,5)P 3 regulates major aspects of cellular behavior, and the use of both genetic and pharmacological inte...

109 research outcomes, page 5 of 11
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